We are analyzing https://link.springer.com/article/10.1007/s00401-002-0569-x.

Title:
Tau accumulation in astrocytes in progressive supranuclear palsy is a degenerative rather than a reactive process | Acta Neuropathologica
Description:
Tau-immunoreactive astrocytes in progressive supranuclear palsy (PSP) have a distinctive morphology and are referred to as tufted astrocytes (TA). We hypothesized that TA may be a degenerative change in reactive astrocytes. To test this hypothesis we examined the relationship of TA to gliosis in PSP. We first examined the distribution of gliosis [glial fibrillary acid protein (GFAP)-positive astrocytes], TA, neurofibrillary tangles (NFT) and pretangles in brain sections of neuropathologically pure PSP cases. Second, we examined PSP cases complicated by infarcts or Alzheimer
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Mobile Technology & AI
Social Networks
Politics

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,734,772 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

astrocytes, article, tau, gliosis, progressive, supranuclear, palsy, reactive, psp, access, privacy, cookies, content, information, publish, search, accumulation, degenerative, distribution, glial, nft, cases, open, august, data, log, journal, research, acta, process, togo, dickson, examined, lesions, discover, springer, optional, personal, parties, policy, change, find, track, neuropathologica, cite, takashi, dennis, explore, tufted, protein,

Topics {✒️}

month download article/chapter progressive supranuclear palsy takashi togo & dennis related subjects full article pdf privacy choices/manage cookies neurofibrillary tangles β-amyloid protein tau-immunoreactive astrocytes check access instant access european economic area article togo conditions privacy policy accepting optional cookies tufted astrocytes tau accumulation main content log journal finder publish article log disease acta neuropathol 104 article cite privacy policy personal data brain sections books a reactive process information optional cookies manage preferences reactive astrocytes gliosis prominent gliosis paralleled data protection essential cookies cookies skip subscription content similar content institution subscribe journal publish positive astrocytes] usage analysis social media varying standards october 2002 volume 104 distinctive morphology double immunostaining tau triple immunostaining

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Tau accumulation in astrocytes in progressive supranuclear palsy is a degenerative rather than a reactive process
         description: Tau-immunoreactive astrocytes in progressive supranuclear palsy (PSP) have a distinctive morphology and are referred to as tufted astrocytes (TA). We hypothesized that TA may be a degenerative change in reactive astrocytes. To test this hypothesis we examined the relationship of TA to gliosis in PSP. We first examined the distribution of gliosis [glial fibrillary acid protein (GFAP)-positive astrocytes], TA, neurofibrillary tangles (NFT) and pretangles in brain sections of neuropathologically pure PSP cases. Second, we examined PSP cases complicated by infarcts or Alzheimer's disease, since these cases would have reactive astrocytes associated with lesions. We used double immunostaining for GFAP and tau for cases with vascular lesions, and triple immunostaining for GFAP, tau and β-amyloid protein for sections with senile plaques. There was no correlation between the distribution of gliosis and TA, with gliosis prominent in globus pallidus and subthalamic nucleus, and TA prominent in motor cortex and striatum. On the other hand, gliosis paralleled the distribution of NFT, but not the distribution of pretangles, suggesting that NFT contributes to gliosis in PSP. Although reactive astrocytes were present around infarcts and senile plaques, TA were not associated with these lesions. Tau accumulation in astrocytes in PSP was not preferential to (and was actually independent of) reactive astrocytes. This is consistent with the notion that tau accumulation in astrocytes is a degenerative rather than reactive process. Unlike NFT, astrocytic degeneration does not seem to contribute to gliosis or neuronal loss in PSP, and its clinical significance remains unclear.
         datePublished:
         dateModified:
         pageStart:398
         pageEnd:402
         sameAs:https://doi.org/10.1007/s00401-002-0569-x
         keywords:
            Progressive supranuclear palsy Tufted astrocytes Gliosis Neurofibrillary tangles
            Pathology
            Neurosciences
         image:
         isPartOf:
            name:Acta Neuropathologica
            issn:
               1432-0533
               0001-6322
            volumeNumber:104
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Takashi Togo
               affiliation:
                     name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
                     address:
                        name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Dennis W. Dickson
               affiliation:
                     name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
                     address:
                        name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA,
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Tau accumulation in astrocytes in progressive supranuclear palsy is a degenerative rather than a reactive process
      description: Tau-immunoreactive astrocytes in progressive supranuclear palsy (PSP) have a distinctive morphology and are referred to as tufted astrocytes (TA). We hypothesized that TA may be a degenerative change in reactive astrocytes. To test this hypothesis we examined the relationship of TA to gliosis in PSP. We first examined the distribution of gliosis [glial fibrillary acid protein (GFAP)-positive astrocytes], TA, neurofibrillary tangles (NFT) and pretangles in brain sections of neuropathologically pure PSP cases. Second, we examined PSP cases complicated by infarcts or Alzheimer's disease, since these cases would have reactive astrocytes associated with lesions. We used double immunostaining for GFAP and tau for cases with vascular lesions, and triple immunostaining for GFAP, tau and β-amyloid protein for sections with senile plaques. There was no correlation between the distribution of gliosis and TA, with gliosis prominent in globus pallidus and subthalamic nucleus, and TA prominent in motor cortex and striatum. On the other hand, gliosis paralleled the distribution of NFT, but not the distribution of pretangles, suggesting that NFT contributes to gliosis in PSP. Although reactive astrocytes were present around infarcts and senile plaques, TA were not associated with these lesions. Tau accumulation in astrocytes in PSP was not preferential to (and was actually independent of) reactive astrocytes. This is consistent with the notion that tau accumulation in astrocytes is a degenerative rather than reactive process. Unlike NFT, astrocytic degeneration does not seem to contribute to gliosis or neuronal loss in PSP, and its clinical significance remains unclear.
      datePublished:
      dateModified:
      pageStart:398
      pageEnd:402
      sameAs:https://doi.org/10.1007/s00401-002-0569-x
      keywords:
         Progressive supranuclear palsy Tufted astrocytes Gliosis Neurofibrillary tangles
         Pathology
         Neurosciences
      image:
      isPartOf:
         name:Acta Neuropathologica
         issn:
            1432-0533
            0001-6322
         volumeNumber:104
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Takashi Togo
            affiliation:
                  name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
                  address:
                     name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dennis W. Dickson
            affiliation:
                  name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
                  address:
                     name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA,
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Acta Neuropathologica
      issn:
         1432-0533
         0001-6322
      volumeNumber:104
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
      address:
         name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA,
         type:PostalAddress
      name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
      address:
         name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA,
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Takashi Togo
      affiliation:
            name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
            address:
               name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA,
               type:PostalAddress
            type:Organization
      name:Dennis W. Dickson
      affiliation:
            name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
            address:
               name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA,
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA,
      name:Departments of Pathology (Neuropathology) and Neuroscience, Birdsall 317, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA,
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(27)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.86s.

LINK . SPRINGER . COM {}