We are analyzing https://link.springer.com/article/10.1007/s00395-003-0431-x.

Title:
TNFα in ischemia/reperfusion injury and heart failure | Basic Research in Cardiology
Description:
During myocardial ischemia, both the myocardial and serum TNFα concentrations are rapidly increased within the area at risk. With prolongation of ischemia and development of cardiomyocyte necrosis, the TNFα concentration increases also in the surrounding viable portions of the myocardium. Indeed, in the scenario of myocardial ischemia/reperfusion, treatment with TNFα antibodies reduced the extent of myocardial infarction in rabbits and attenuated the contractile dysfunction following microembolization in dogs. In the latter studies, the serum TNFα concentration remained unaltered thereby supporting the notion of a direct action of TNFα at the level of cardiomyocytes during ischemia/reperfusion. In heart failure, the serum TNFα concentration is also increased, and in patients with advanced heart failure the serum TNFα concentration is an independent predictor of mortality. The origin of the increased serum TNFα concentration is not clearly identiﬁed yet, but TNFα derived from the heart and peripheral organs contributes to the increased serum TNFα concentration. Treatment with TNFα antibodies in the clinical scenario, however, did not improve the prognosis of heart failure patients.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Fitness & Wellness
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

tnfα, heart, article, failure, research, serum, concentration, privacy, cookies, content, basic, schulz, myocardial, access, publish, search, ischemiareperfusion, cardiac, rainer, increased, author, data, information, log, journal, aker, belosjorow, ischemia, treatment, discover, springer, optional, personal, parties, area, policy, find, track, cardiology, injury, society, published, august, cite, stephanie, sergej, gerd, heusch, explore, scenario,

Topics {✒️}

month download article/chapter heart failure published advanced heart failure heart failure patients heart research europe myocardial infarction heart failure article basic research optimal cardiac regeneration myocardial ischemia/reperfusion rainer schulz german cardiac society privacy choices/manage cookies author correspondence serum tnfα concentration cardiomyocyte necrosis serum tnfα concentrations tnfα concentration increases full article pdf ischemia/reperfusion injury tnfα antibodies reduced article schulz surrounding viable portions peripheral organs contributes related subjects myocardial ischemia check access instant access conditions privacy policy accepting optional cookies european economic area microembolization cardiac impairment main content log journal finder publish ischemia/reperfusion heart tnfα antibodies information privacy policy tnfα derived personal data article log books a basic mechanisms article cite optional cookies manage preferences myocardial rapidly increased

Schema {🗺️}

WebPage:
      mainEntity:
         headline:TNFα in ischemia/reperfusion injury and heart failure
         description:During myocardial ischemia, both the myocardial and serum TNFα concentrations are rapidly increased within the area at risk. With prolongation of ischemia and development of cardiomyocyte necrosis, the TNFα concentration increases also in the surrounding viable portions of the myocardium. Indeed, in the scenario of myocardial ischemia/reperfusion, treatment with TNFα antibodies reduced the extent of myocardial infarction in rabbits and attenuated the contractile dysfunction following microembolization in dogs. In the latter studies, the serum TNFα concentration remained unaltered thereby supporting the notion of a direct action of TNFα at the level of cardiomyocytes during ischemia/reperfusion. In heart failure, the serum TNFα concentration is also increased, and in patients with advanced heart failure the serum TNFα concentration is an independent predictor of mortality. The origin of the increased serum TNFα concentration is not clearly identiﬁed yet, but TNFα derived from the heart and peripheral organs contributes to the increased serum TNFα concentration. Treatment with TNFα antibodies in the clinical scenario, however, did not improve the prognosis of heart failure patients.
         datePublished:2003-08-05T00:00:00Z
         dateModified:2003-08-05T00:00:00Z
         pageStart:8
         pageEnd:11
         sameAs:https://doi.org/10.1007/s00395-003-0431-x
         keywords:
            Review
            TNFα
            ischemia
            microembolization
            heart failure
            Cardiology
         image:
         isPartOf:
            name:Basic Research in Cardiology
            issn:
               1435-1803
               0300-8428
            volumeNumber:99
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Steinkopff-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Rainer Schulz
               affiliation:
                     name:Universitätsklinikum Essen
                     address:
                        name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Stephanie Aker
               affiliation:
                     name:Universitätsklinikum Essen
                     address:
                        name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sergej Belosjorow
               affiliation:
                     name:Universitätsklinikum Essen
                     address:
                        name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gerd Heusch
               affiliation:
                     name:Universitätsklinikum Essen
                     address:
                        name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:TNFα in ischemia/reperfusion injury and heart failure
      description:During myocardial ischemia, both the myocardial and serum TNFα concentrations are rapidly increased within the area at risk. With prolongation of ischemia and development of cardiomyocyte necrosis, the TNFα concentration increases also in the surrounding viable portions of the myocardium. Indeed, in the scenario of myocardial ischemia/reperfusion, treatment with TNFα antibodies reduced the extent of myocardial infarction in rabbits and attenuated the contractile dysfunction following microembolization in dogs. In the latter studies, the serum TNFα concentration remained unaltered thereby supporting the notion of a direct action of TNFα at the level of cardiomyocytes during ischemia/reperfusion. In heart failure, the serum TNFα concentration is also increased, and in patients with advanced heart failure the serum TNFα concentration is an independent predictor of mortality. The origin of the increased serum TNFα concentration is not clearly identiﬁed yet, but TNFα derived from the heart and peripheral organs contributes to the increased serum TNFα concentration. Treatment with TNFα antibodies in the clinical scenario, however, did not improve the prognosis of heart failure patients.
      datePublished:2003-08-05T00:00:00Z
      dateModified:2003-08-05T00:00:00Z
      pageStart:8
      pageEnd:11
      sameAs:https://doi.org/10.1007/s00395-003-0431-x
      keywords:
         Review
         TNFα
         ischemia
         microembolization
         heart failure
         Cardiology
      image:
      isPartOf:
         name:Basic Research in Cardiology
         issn:
            1435-1803
            0300-8428
         volumeNumber:99
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Steinkopff-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Rainer Schulz
            affiliation:
                  name:Universitätsklinikum Essen
                  address:
                     name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Stephanie Aker
            affiliation:
                  name:Universitätsklinikum Essen
                  address:
                     name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sergej Belosjorow
            affiliation:
                  name:Universitätsklinikum Essen
                  address:
                     name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gerd Heusch
            affiliation:
                  name:Universitätsklinikum Essen
                  address:
                     name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Basic Research in Cardiology
      issn:
         1435-1803
         0300-8428
      volumeNumber:99
Organization:
      name:Steinkopff-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Universitätsklinikum Essen
      address:
         name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
         type:PostalAddress
      name:Universitätsklinikum Essen
      address:
         name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
         type:PostalAddress
      name:Universitätsklinikum Essen
      address:
         name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
         type:PostalAddress
      name:Universitätsklinikum Essen
      address:
         name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Rainer Schulz
      affiliation:
            name:Universitätsklinikum Essen
            address:
               name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Stephanie Aker
      affiliation:
            name:Universitätsklinikum Essen
            address:
               name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
               type:PostalAddress
            type:Organization
      name:Sergej Belosjorow
      affiliation:
            name:Universitätsklinikum Essen
            address:
               name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
               type:PostalAddress
            type:Organization
      name:Gerd Heusch
      affiliation:
            name:Universitätsklinikum Essen
            address:
               name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
      name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
      name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
      name:Institut für Pathophysiologie, Universitätsklinikum Essen, Essen
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(31)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.43s.

LINK . SPRINGER . COM {}