We are analyzing https://link.springer.com/article/10.1007/s00394-010-0102-2.

Title:
Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol | European Journal of Nutrition
Description:
Background and aims Oxysterols are assumed to play important roles in age-related macular degeneration, a major cause of blindness. So we characterized the cytotoxic, oxidative, inflammatory, and angiogenic activities of oxysterols (7β-hydroxycholesterol (7β-OH), 7-ketocholesterol (7KC), 25-hydroxycholesterol (25-OH)) in human retinal ARPE-19 cells, and evaluated the protective effects of resveratrol (Rsv: 1 μM), a polyphenol from red wine. Methods ARPE-19 cells were treated with 7β-OH, 7KC, or 25-OH (5–40 μg/mL; 24–48 h) without or with Rsv. Cell viability was determined using trypan blue and the MTT assay. Cell death was characterized by electron microscopy and in situ detection of activated caspases with fluorochrome-labeled inhibitors of caspases. Reactive oxygen species (ROS) production was measured with hydroethidine. ELISA methods and a cytometric bead assay were used to quantify cytokines involved in inflammation (IL-8, IL-1β, IL-6, IL-10, IL-12p70, TNF-α, MCP-1) and VEGF. Results 7β-OH and 7KC triggered a caspase-independent cell death process associated with the presence of multilamellar cytoplasmic structures evocating phospholipidosis, increased ROS production, and IL-8 secretion. 7β-OH enhanced VEGF secretion. No cytotoxic effects were identified with 25-OH, which highly stimulated ROS production, MCP-1, and VEGF secretion. With oxysterols, no IL-10, TNF-α, and IL-12p70 secretion were detected. 25-OH induced IL-8 secretion through the MEK/ERK½ signaling pathway, and Rsv showed cytoprotective activities and inhibited VEGF secretion. Conclusion 7β-OH, 7KC, and 25-OH have cytotoxic, oxidative, inflammatory, and/or angiogenic activities on ARPE-19 cells. As Rsv has some protective effects against oxysterol-induced cell death and VEGF secretion it could be valuable in ARMD treatment.
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article, google, scholar, cas, cells, cell, lizard, human, vegf, oxysterols, retinal, secretion, resveratrol, effects, res, ophthalmol, biol, agerelated, sci, dijon, arpe, malvitte, ketocholesterol, death, pigment, epithelial, france, production, bron, creuzotgarcher, macular, degeneration, cytotoxic, inflammation, apoptosis, eye, vejux, invest, vis, privacy, cookies, content, journal, inflammatory, cytokines, βoh, phospholipidosis, montange, gambert, vascular,

Topics {✒️}

nf-kappab-mediated interleukin-8 expression reactive oxygen species month download article/chapter oxidized low-density lipoprotein age-related macular degeneration oxysterol-induced cell death free radical-mediated mechanism caspase-3-independent mode tumor necrosis factor-alpha human retinal cells université de bourgogne trans-resveratrol analogs molecules human arpe-19 cells mek/erk½ signaling pathway anti-inflammatory cytokines drug-induced phospholipidosis article european journal retinal oxysterol pathway oxysterols-induced il-8 secretion cultured rpe cells quantify cytokines involved full article pdf age-related maculopathy privacy choices/manage cookies lipid peroxidation products cultured neuroretinal cells erk1/2 signalling pathway chronic oxidative stress retinal flavoprotein autofluorescence endometrial tumour cells trabecular meshwork cells gougerot-pocidalo ma human atherosclerotic lesions european economic area van breda sg cell cycle progression inflammatory cytokines glaucoma markers induced 7-ketocholesterol upregulates interleukin-6 lipopolysaccharide-stimulated monocytes mek/erk cascade oxysterol-induced toxicity angiogenic cytokine expression related subjects wine-related polyphenols pro-inflammatory characteristics check access instant access cell death chu de dijon

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         Caspase-independent cell death
         Inflammatory cytokines
         Oxysterols
         Phospholipidosis
         Resveratrol
         Reactive oxygen species
         VEGF
         Nutrition
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