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Title:
Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer | International Journal of Colorectal Disease
Description:
Background and Objectives Adjuvant chemotherapy for stage II colon cancer remains controversial but may be considered for patients with high-risk features. Recent studies have shown that elevated neutrophil to lymphocyte ratio (NLR) is a worse prognostic factor and a predictor of response to chemotherapy in patients with advanced colorectal cancer. The purpose of this study was to evaluate whether NLR predicts risk of recurrence in patients with stage IIA colon cancer undergoing curative resection without adjuvant chemotherapy. Methods We retrospectively reviewed 141 consecutive patients with stage IIA colon cancer treated with curative surgery alone from 2002 to 2006. NLR, as well as demographics, clinical, histopathologic, and laboratory data were analyzed. Univariate and multivariate analyses were conducted to identify prognostic factors associated with recurrent-free survival (RFS). Results Cox’s regression analysis demonstrated that elevated NLR (>4) (hazard ratio, 4.88; P < 0.01) and less lymph node sampling (<15 lymph nodes; hazard ratio, 3.80; P < 0.05) were adverse prognostic factors for RFS. The 5-year RFS was 91.4% (95% CI, 88.6–94.2%) for patients with normal NLR and 63.8% (51.1–76.3%) for patients with elevated NLR. The 5-year RFS for patients with 0, 1, and 2 of the identified risk factors was 95.1%, 87.4%, and 33.3%, respectively (P < 0.001). Conclusions Elevated preoperative NLR is an independent predictor of worse RFS for patients with stage IIA colon cancer and a potential biomarker to identify candidates for adjuvant chemotherapy.
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cancer, article, google, scholar, pubmed, colon, colorectal, stage, patients, ratio, cas, oncol, chemotherapy, prognostic, surg, adjuvant, resection, elevated, lymphocyte, nlr, neutrophil, curative, iia, survival, predicts, predictor, lymph, prognosis, tumor, preoperative, risk, factor, access, privacy, cookies, content, data, journal, recurrence, ding, rfs, clin, dis, ann, information, publish, search, peirong, xin, zhang,
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month download article/chapter sun yat-sen university zhi-zhong pan acknowledge jie-rong wang fluorouracil-based adjuvant therapy iii colon cancer related subjects fluorouracil-based adjuvant chemotherapy american joint committee tumor microsatellite-instability status article international journal preoperative neutrophil–lymphocyte ratio t3 colon cancer full article pdf de boer jp t3n0 colon cancer advanced colorectal cancer human colorectal cancer privacy choices/manage cookies colorectal disease aims jun-zhong lin poor prognostic factor t3n0 colorectal cancer colorectal cancer patients colorectal liver metastases stage iia microsatellite instability status worse prognostic factor epithelial ovarian cancer primary breast cancer pre-treatment neutrophil article ding disease-free survival pathological ultra-staging elevated preoperative neutrophil tumour angiogenesis population-based study colon cancer tumor infiltrating lymphocytes adverse prognostic factors reproducible prognostic marker stage ii neutrophil-lymphocyte ratio neutrophil/lymphocyte ratio identified risk factors european economic area li-ren li xiao-jun wu ling-heng kong law ch
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headline:Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer
description:Adjuvant chemotherapy for stage II colon cancer remains controversial but may be considered for patients with high-risk features. Recent studies have shown that elevated neutrophil to lymphocyte ratio (NLR) is a worse prognostic factor and a predictor of response to chemotherapy in patients with advanced colorectal cancer. The purpose of this study was to evaluate whether NLR predicts risk of recurrence in patients with stage IIA colon cancer undergoing curative resection without adjuvant chemotherapy. We retrospectively reviewed 141 consecutive patients with stage IIA colon cancer treated with curative surgery alone from 2002 to 2006. NLR, as well as demographics, clinical, histopathologic, and laboratory data were analyzed. Univariate and multivariate analyses were conducted to identify prognostic factors associated with recurrent-free survival (RFS). Cox’s regression analysis demonstrated that elevated NLR (>4) (hazard ratio, 4.88; P < 0.01) and less lymph node sampling (<15 lymph nodes; hazard ratio, 3.80; P < 0.05) were adverse prognostic factors for RFS. The 5-year RFS was 91.4% (95% CI, 88.6–94.2%) for patients with normal NLR and 63.8% (51.1–76.3%) for patients with elevated NLR. The 5-year RFS for patients with 0, 1, and 2 of the identified risk factors was 95.1%, 87.4%, and 33.3%, respectively (P < 0.001). Elevated preoperative NLR is an independent predictor of worse RFS for patients with stage IIA colon cancer and a potential biomarker to identify candidates for adjuvant chemotherapy.
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Neutrophil to lymphocyte ratio
Colon cancer
Stage IIA
Surgery
Internal Medicine
Gastroenterology
Hepatology
Proctology
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description:Adjuvant chemotherapy for stage II colon cancer remains controversial but may be considered for patients with high-risk features. Recent studies have shown that elevated neutrophil to lymphocyte ratio (NLR) is a worse prognostic factor and a predictor of response to chemotherapy in patients with advanced colorectal cancer. The purpose of this study was to evaluate whether NLR predicts risk of recurrence in patients with stage IIA colon cancer undergoing curative resection without adjuvant chemotherapy. We retrospectively reviewed 141 consecutive patients with stage IIA colon cancer treated with curative surgery alone from 2002 to 2006. NLR, as well as demographics, clinical, histopathologic, and laboratory data were analyzed. Univariate and multivariate analyses were conducted to identify prognostic factors associated with recurrent-free survival (RFS). Cox’s regression analysis demonstrated that elevated NLR (>4) (hazard ratio, 4.88; P < 0.01) and less lymph node sampling (<15 lymph nodes; hazard ratio, 3.80; P < 0.05) were adverse prognostic factors for RFS. The 5-year RFS was 91.4% (95% CI, 88.6–94.2%) for patients with normal NLR and 63.8% (51.1–76.3%) for patients with elevated NLR. The 5-year RFS for patients with 0, 1, and 2 of the identified risk factors was 95.1%, 87.4%, and 33.3%, respectively (P < 0.001). Elevated preoperative NLR is an independent predictor of worse RFS for patients with stage IIA colon cancer and a potential biomarker to identify candidates for adjuvant chemotherapy.
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address:
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
type:PostalAddress
type:Organization
name:Cancer Center, Sun Yat-sen University
address:
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
type:PostalAddress
type:Organization
name:Xiao-Jun Wu
affiliation:
name:State Key Laboratory of Oncology in South China
address:
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
type:PostalAddress
type:Organization
name:Cancer Center, Sun Yat-sen University
address:
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
type:PostalAddress
type:Organization
name:Zhen-Hai Lu
affiliation:
name:State Key Laboratory of Oncology in South China
address:
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
type:PostalAddress
type:Organization
name:Cancer Center, Sun Yat-sen University
address:
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
type:PostalAddress
type:Organization
name:Jun-Zhong Lin
affiliation:
name:State Key Laboratory of Oncology in South China
address:
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
type:PostalAddress
type:Organization
name:Cancer Center, Sun Yat-sen University
address:
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
type:PostalAddress
type:Organization
name:Ling-Heng Kong
affiliation:
name:State Key Laboratory of Oncology in South China
address:
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
type:PostalAddress
type:Organization
name:Cancer Center, Sun Yat-sen University
address:
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
type:PostalAddress
type:Organization
name:De-Sen Wan
affiliation:
name:State Key Laboratory of Oncology in South China
address:
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
type:PostalAddress
type:Organization
name:Cancer Center, Sun Yat-sen University
address:
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
type:PostalAddress
type:Organization
name:Zhi-Zhong Pan
affiliation:
name:State Key Laboratory of Oncology in South China
address:
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
type:PostalAddress
type:Organization
name:Cancer Center, Sun Yat-sen University
address:
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
name:Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
name:State Key Laboratory of Oncology in South China, Guangzhou, People’s Republic of China
name:Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China
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