We are analyzing https://link.springer.com/article/10.1007/s00380-018-1136-2.

Title:
Comparison of the effects of linagliptin and voglibose on endothelial function in patients with type 2 diabetes and coronary artery disease: a prospective, randomized, pilot study (EFFORT) | Heart and Vessels
Description:
Endothelial dysfunction contributes to poor cardiovascular prognosis in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). The effect of dipeptidyl peptidase-4 inhibitors on endothelial function remains controversial. We sought to compare the effects of linagliptin and voglibose on endothelial function, as assessed by reactive hyperemia-peripheral arterial tonometry (RH-PAT). Sixteen patients with newly diagnosed T2DM and CAD were randomized 1:1 to linagliptin (5 mg, once-daily) or voglibose (0.9 mg, thrice-daily). The RH-PAT and laboratory parameters, including 75 g oral glucose tolerance test, were measured at baseline and 3 months. Linagliptin increased serum levels of active glucagon-like peptide-1 and high-molecular-weight adiponectin. Age-, sex-, and baseline-adjusted changes in logarithmic RH-PAT index (LnRHI) after 3 months were significant between groups (linagliptin, 0.135 ± 0.097; voglibose, − 0.124 ± 0.091; P = 0.047). In the linagliptin group, change in LnRHI was positively correlated with change in high-density lipoprotein cholesterol and negatively correlated with changes in both urine albumin-to-creatinine ratio and high-sensitivity C-reactive protein. Furthermore, linagliptin treatment for 3 months reduced serum levels of both glucose and insulin at 2 h, relative to voglibose, in the age-, sex-, and baseline-adjusted model. Linagliptin improved endothelial function relative to voglibose, accompanied by amelioration of glycemic, renal, and cardiometabolic parameters, in patients with newly diagnosed T2DM and CAD. Trial registration Unique Trial Number, UMIN 000029169 ( https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000012442 ).
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Keywords {🔍}

pubmed, article, endothelial, google, scholar, cas, function, diabetes, linagliptin, patients, type, central, heart, artery, voglibose, coronary, disease, study, dysfunction, vascular, research, tanaka, cardiovasc, japan, privacy, cookies, content, randomized, node, dipeptidyl, peptidase, related, inhibitor, publish, search, vessels, effects, manuscript, inoue, cardiovascular, effect, glucose, access, lerman, diabetol, saga, mitsubishi, tanabe, boehringer, ingelheim,

Topics {✒️}

jp/cgi-open-bin/ctr_e/ctr_view high-sensitivity c-reactive protein month download article/chapter jun-ichi oyama high-density lipoprotein cholesterol high-molecular-weight adiponectin logarithmic rh-pat index full article pdf coronary artery disease dipeptidyl peptidase-4 inhibitors koichi node privacy choices/manage cookies masashi sakuma & teruo inoue research program faculty endothelial vasomotor function dipeptidyl peptidase-4 inhibitor author information authors article koyama improves endothelial dysfunction unique pharmacological profile dipeptidyl-peptidase 4 inhibition ameliorates endothelial dysfunction early endothelial dysfunction boston scientific japan diabetes mellitus serum adiponectin level vascular endothelial functions european economic area short communication published flow-mediated vasodilatation stabilises arteriosclerotic lesions flow-mediated vasodilation excellent secretarial assistance ethics declarations conflict placebo-controlled study conditions privacy policy newly diagnosed t2dm poor cardiovascular prognosis prologue study investigators article log glucose-independent improvement article heart accepting optional cookies check access fukuoka wajiro hospital instant access dokkyo medical university endothelial function baseline-adjusted model anti-inflammatory effects

Questions {❓}

Ceriello A (2005) Postprandial hyperglycemia and diabetes complications: is it time to treat?

Schema {🗺️}

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         description:Endothelial dysfunction contributes to poor cardiovascular prognosis in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). The effect of dipeptidyl peptidase-4 inhibitors on endothelial function remains controversial. We sought to compare the effects of linagliptin and voglibose on endothelial function, as assessed by reactive hyperemia-peripheral arterial tonometry (RH-PAT). Sixteen patients with newly diagnosed T2DM and CAD were randomized 1:1 to linagliptin (5 mg, once-daily) or voglibose (0.9 mg, thrice-daily). The RH-PAT and laboratory parameters, including 75 g oral glucose tolerance test, were measured at baseline and 3 months. Linagliptin increased serum levels of active glucagon-like peptide-1 and high-molecular-weight adiponectin. Age-, sex-, and baseline-adjusted changes in logarithmic RH-PAT index (LnRHI) after 3 months were significant between groups (linagliptin, 0.135 ± 0.097; voglibose, − 0.124 ± 0.091; P = 0.047). In the linagliptin group, change in LnRHI was positively correlated with change in high-density lipoprotein cholesterol and negatively correlated with changes in both urine albumin-to-creatinine ratio and high-sensitivity C-reactive protein. Furthermore, linagliptin treatment for 3 months reduced serum levels of both glucose and insulin at 2 h, relative to voglibose, in the age-, sex-, and baseline-adjusted model. Linagliptin improved endothelial function relative to voglibose, accompanied by amelioration of glycemic, renal, and cardiometabolic parameters, in patients with newly diagnosed T2DM and CAD. Trial registration Unique Trial Number, UMIN 000029169 ( https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000012442 ).
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