We are analyzing https://link.springer.com/article/10.1007/s00330-006-0505-x.

Title:
Relationship between DCE-MRI morphological and functional features and histopathological characteristics of breast cancer | European Radiology
Description:
We studied whether dynamic contrast-enhanced MRI (DCE-MRI) could identify histopathological characteristics of breast cancer. Seventy-five patients with breast cancer underwent DCE-MRI followed by core biopsy. DCE-MRI findings were evaluated following the scoring system published by Fischer in 1999. In this scoring system, five DCE-MRI features, three morphological (shape, margins, enhancement kinetic) and two functional (initial peak of signal intensity (SI) increase and behavior of signal intensity curve), are defined by 14 parameters. Each parameter is assigned points ranging from 0 to 1 or 0 to 2, with higher points for those that are more likely to be associated with malignancy. The sum of all the points defines the degree of suspicion of malignancy, with a score 0 representing the lowest and 8 the highest degree of suspicion. Associations between DCE-MRI features and tumor histopathological characteristics assessed on core biopsies (histological type, grading, estrogen and progesterone receptor status, Ki67 and HER2 status) were studied by contingency tables and logistic regression analysis. We found a significant inverse association between the Fischer’s score and HER2-overexpression (odds ratio-OR 0.608, p = 0.02). Based on our results, we suggest that lesions with intermediate-low suspicious DCE-MRI parameters may represent a subset of tumor with poor histopathological characteristics.
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Keywords {🔍}

breast, article, google, scholar, pubmed, cancer, imaging, cas, magnetic, resonance, dynamic, radiol, dcemri, features, eur, contrastenhanced, mri, research, histopathological, montemurro, martincich, functional, characteristics, core, invasive, correlation, doi, chemotherapy, privacy, cookies, content, radiology, enhancement, tumor, lesions, access, carcinoma, factors, diagnostic, unit, institute, torino, italy, analysis, information, publish, search, laura, biopsy, fischer,

Topics {✒️}

month download article/chapter dynamic contrast-enhanced mri magnetic resonance imaging surgical excision specimens carboxymethyldextran-a2-gd-dota her2-positive breast cancer dynamic gd-dtpa enhancement magnetic resonance characterization reproducible bi-rads features magnetic resonance mammography dynamic mr imaging mr molecular imaging serial enhanced mri surgical pathology full article pdf tumour vascular function contrast enhancement characteristics dynamic breast mri privacy choices/manage cookies quantitative dynamic mri european economic area medical oncology dynamic mr features breast dce-mri dce-mri features article montemurro dce-mri findings dce-mri morphological invasive breast cancers malignant breast masses scoring system published improved preoperative staging mr imaging breast cancer cells invasive breast cancer human breast cancer symptomatic breast cancer primary breast cancer significant inverse association atypical ductal hyperplasia knopp mv international expert consensus amy yen mf von tengg-kobligk van die le tumour grade peripheral rim enhancement malignant breast lesions mammographic tumor features conditions privacy policy

Questions {❓}

Burge CN, Chang HR, Apple SK (2006) Do the histologic features and results of breast cancer biomarker studies differ between core biopsy and surgical excision specimens?

Schema {🗺️}

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         headline:Relationship between DCE-MRI morphological and functional features and histopathological characteristics of breast cancer
         description:We studied whether dynamic contrast-enhanced MRI (DCE-MRI) could identify histopathological characteristics of breast cancer. Seventy-five patients with breast cancer underwent DCE-MRI followed by core biopsy. DCE-MRI findings were evaluated following the scoring system published by Fischer in 1999. In this scoring system, five DCE-MRI features, three morphological (shape, margins, enhancement kinetic) and two functional (initial peak of signal intensity (SI) increase and behavior of signal intensity curve), are defined by 14 parameters. Each parameter is assigned points ranging from 0 to 1 or 0 to 2, with higher points for those that are more likely to be associated with malignancy. The sum of all the points defines the degree of suspicion of malignancy, with a score 0 representing the lowest and 8 the highest degree of suspicion. Associations between DCE-MRI features and tumor histopathological characteristics assessed on core biopsies (histological type, grading, estrogen and progesterone receptor status, Ki67 and HER2 status) were studied by contingency tables and logistic regression analysis. We found a significant inverse association between the Fischer’s score and HER2-overexpression (odds ratio-OR 0.608, p = 0.02). Based on our results, we suggest that lesions with intermediate-low suspicious DCE-MRI parameters may represent a subset of tumor with poor histopathological characteristics.
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      headline:Relationship between DCE-MRI morphological and functional features and histopathological characteristics of breast cancer
      description:We studied whether dynamic contrast-enhanced MRI (DCE-MRI) could identify histopathological characteristics of breast cancer. Seventy-five patients with breast cancer underwent DCE-MRI followed by core biopsy. DCE-MRI findings were evaluated following the scoring system published by Fischer in 1999. In this scoring system, five DCE-MRI features, three morphological (shape, margins, enhancement kinetic) and two functional (initial peak of signal intensity (SI) increase and behavior of signal intensity curve), are defined by 14 parameters. Each parameter is assigned points ranging from 0 to 1 or 0 to 2, with higher points for those that are more likely to be associated with malignancy. The sum of all the points defines the degree of suspicion of malignancy, with a score 0 representing the lowest and 8 the highest degree of suspicion. Associations between DCE-MRI features and tumor histopathological characteristics assessed on core biopsies (histological type, grading, estrogen and progesterone receptor status, Ki67 and HER2 status) were studied by contingency tables and logistic regression analysis. We found a significant inverse association between the Fischer’s score and HER2-overexpression (odds ratio-OR 0.608, p = 0.02). Based on our results, we suggest that lesions with intermediate-low suspicious DCE-MRI parameters may represent a subset of tumor with poor histopathological characteristics.
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         Contrast media
         Breast neoplasms
         Pathology
         HER2
         Imaging / Radiology
         Diagnostic Radiology
         Interventional Radiology
         Neuroradiology
         Ultrasound
         Internal Medicine
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