We are analyzing https://link.springer.com/article/10.1007/s00294-021-01168-1.

Title:
RNA modifications as a common denominator between tRNA and mRNA | Current Genetics
Description:
Recent studies underscore RNA modifications as a novel mechanism to coordinate expression and function of different genes. While modifications on the sugar or base moieties of tRNA are well known, their roles in mRNA regulation are only starting to emerge. Interestingly, some modifications are present in both tRNA and mRNA, and here we discuss the functional significance of these common features. We describe key modifications that are present in both RNA types, elaborate on proteins that interact with them, and indicate recent works that identify roles in communicating tRNA processes and mRNA regulation. We propose that as tools are developed, the shortlist of features that are common between types of RNA will greatly expand and proteins that interact with them will be identified. In conclusion, the presence of the same modification in both RNA types provides an intersect between tRNA processes and mRNA regulation and implies a novel mechanism for connecting diverse cellular processes.
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Keywords {🔍}

article, google, scholar, pubmed, rna, cas, trna, central, modifications, mrna, nat, biol, regulation, methylation, modification, editing, res, pseudouridine, cell, levi, arava, nucleic, acids, genet, proteins, chem, human, httpsdoiorgs, privacy, cookies, function, content, genes, mammalian, functions, rev, nature, translation, sci, dnmt, mol, data, information, publish, research, search, common, manuscript, access, rnas,

Topics {✒️}

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Questions {❓}

Frye M, Jaffrey SR, Pan T et al (2016) RNA modifications: what have we learned and where are we headed?
RNA modifications: what have we learned and where are we headed?
Rintala-Dempsey AC, Kothe U (2017) Eukaryotic stand-alone pseudouridine synthases—RNA modifying enzymes and emerging regulators of gene expression?

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         description:Recent studies underscore RNA modifications as a novel mechanism to coordinate expression and function of different genes. While modifications on the sugar or base moieties of tRNA are well known, their roles in mRNA regulation are only starting to emerge. Interestingly, some modifications are present in both tRNA and mRNA, and here we discuss the functional significance of these common features. We describe key modifications that are present in both RNA types, elaborate on proteins that interact with them, and indicate recent works that identify roles in communicating tRNA processes and mRNA regulation. We propose that as tools are developed, the shortlist of features that are common between types of RNA will greatly expand and proteins that interact with them will be identified. In conclusion, the presence of the same modification in both RNA types provides an intersect between tRNA processes and mRNA regulation and implies a novel mechanism for connecting diverse cellular processes.
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         mRNA
         Pseudouridine
         m6A
         Inosine
         m5C
         Translation
         RNA binding proteins
         Microbial Genetics and Genomics
         Microbiology
         Biochemistry
         general
         Cell Biology
         Plant Sciences
         Proteomics
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