We are analyzing https://link.springer.com/article/10.1007/s00281-024-01017-6.

Title:
The role of microglia in early neurodevelopment and the effects of maternal immune activation | Seminars in Immunopathology
Description:
Activation of the maternal immune system during gestation has been associated with an increased risk for neurodevelopmental disorders in the offspring, particularly schizophrenia and autism spectrum disorder. Microglia, the tissue-resident macrophages of the central nervous system, are implicated as potential mediators of this increased risk. Early in development, microglia start populating the embryonic central nervous system and in addition to their traditional role as immune responders under homeostatic conditions, microglia are also intricately involved in various early neurodevelopmental processes. The timing of immune activation may interfere with microglia functioning during early neurodevelopment, potentially leading to long-term consequences in postnatal life. In this review we will discuss the involvement of microglia in brain development during the prenatal and early postnatal stages of life, while also examining the effects of maternal immune activation on microglia and neurodevelopmental processes. Additionally, we discuss recent single cell RNA-sequencing studies focusing on microglia during prenatal development, and hypothesize how early life microglial priming, potentially through epigenetic reprogramming, may be related to neurodevelopmental disorders.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,643,078 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

microglia, pubmed, microglial, article, immune, google, scholar, mia, brain, cas, activation, development, cells, synaptic, maternal, early, fetal, central, cell, mice, prenatal, cns, studies, increased, postnatal, neurodevelopmental, expression, response, found, adult, offspring, neural, pruning, developing, neurodevelopment, results, role, risk, interneurons, disorders, human, processes, life, cortex, httpsdoiorgs, ndds, synapses, genes, evidence, phenotype,

Topics {✒️}

single-cell rna sequencing single-cell studies focusing recent scrna-seq paper brain-derived neurotrophic factor central nervous system maternal interleukin-17a pathway article download pdf high-plex spatial proteomics step-wise maturation process main tissue-resident macrophages inhibiting microglial-neural interactions earlier developmental time-points periventricular white-matter injury perturbing microglial-neural crosstalk time-dependent remains elusive excitatory pre-synaptic structures maternal immune stressors microglial-dependent synaptic pruning maternal allergic asthma limiting microglia-neural interactions direct rna sequencing scz-derived microglia displayed initial male-specific overgrowth fractalkine-dependent microglial pruning map microglial-cell interactions cns pro-inflammatory response schizophrenia patient-derived models increased neuro-inflammatory profile de oliveira cl parvalbumin-positive interneurons lipopolysaccharide induces inflammation scz-derived cortical interneurons maternal immune activation modulating microglial activation maternal immune system �immune-enriched’ microglial clusters ameliorate mia-induced behavioural scrna-seq data identified phenomenon highly relevant gaba-responsive microglia privacy choices/manage cookies astrocyte-microglial interactions ameliorate mia-induced effects undergoing morphogenetic stress immune-sensing receptors long-lasting functional consequences mia-related immune factors single activation markers neural progenitor cell molecular mechanisms underlying

Questions {❓}

Feinberg I (1982) Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The role of microglia in early neurodevelopment and the effects of maternal immune activation
         description:Activation of the maternal immune system during gestation has been associated with an increased risk for neurodevelopmental disorders in the offspring, particularly schizophrenia and autism spectrum disorder. Microglia, the tissue-resident macrophages of the central nervous system, are implicated as potential mediators of this increased risk. Early in development, microglia start populating the embryonic central nervous system and in addition to their traditional role as immune responders under homeostatic conditions, microglia are also intricately involved in various early neurodevelopmental processes. The timing of immune activation may interfere with microglia functioning during early neurodevelopment, potentially leading to long-term consequences in postnatal life. In this review we will discuss the involvement of microglia in brain development during the prenatal and early postnatal stages of life, while also examining the effects of maternal immune activation on microglia and neurodevelopmental processes. Additionally, we discuss recent single cell RNA-sequencing studies focusing on microglia during prenatal development, and hypothesize how early life microglial priming, potentially through epigenetic reprogramming, may be related to neurodevelopmental disorders.
         datePublished:2024-07-11T00:00:00Z
         dateModified:2024-07-11T00:00:00Z
         pageStart:1
         pageEnd:14
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s00281-024-01017-6
         keywords:
            Neurodevelopment
            Prenatal development
            Immune system
            Microglia
            Maternal immune activation
            Immunology
            Internal Medicine
            Pathology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-024-01017-6/MediaObjects/281_2024_1017_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-024-01017-6/MediaObjects/281_2024_1017_Fig2_HTML.png
         isPartOf:
            name:Seminars in Immunopathology
            issn:
               1863-2300
               1863-2297
            volumeNumber:46
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:L. J. M. Mastenbroek
               affiliation:
                     name:University Medical Center Groningen, University of Groningen
                     address:
                        name:Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:S. M. Kooistra
               url:http://orcid.org/0000-0003-0211-8283
               affiliation:
                     name:University of Groningen
                     address:
                        name:Department of BioMedical Sciences, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:B. J. L. Eggen
               url:http://orcid.org/0000-0001-8941-0353
               affiliation:
                     name:University of Groningen
                     address:
                        name:Department of BioMedical Sciences, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:J. R. Prins
               url:http://orcid.org/0000-0002-3984-2163
               affiliation:
                     name:University Medical Center Groningen, University of Groningen
                     address:
                        name:Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The role of microglia in early neurodevelopment and the effects of maternal immune activation
      description:Activation of the maternal immune system during gestation has been associated with an increased risk for neurodevelopmental disorders in the offspring, particularly schizophrenia and autism spectrum disorder. Microglia, the tissue-resident macrophages of the central nervous system, are implicated as potential mediators of this increased risk. Early in development, microglia start populating the embryonic central nervous system and in addition to their traditional role as immune responders under homeostatic conditions, microglia are also intricately involved in various early neurodevelopmental processes. The timing of immune activation may interfere with microglia functioning during early neurodevelopment, potentially leading to long-term consequences in postnatal life. In this review we will discuss the involvement of microglia in brain development during the prenatal and early postnatal stages of life, while also examining the effects of maternal immune activation on microglia and neurodevelopmental processes. Additionally, we discuss recent single cell RNA-sequencing studies focusing on microglia during prenatal development, and hypothesize how early life microglial priming, potentially through epigenetic reprogramming, may be related to neurodevelopmental disorders.
      datePublished:2024-07-11T00:00:00Z
      dateModified:2024-07-11T00:00:00Z
      pageStart:1
      pageEnd:14
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s00281-024-01017-6
      keywords:
         Neurodevelopment
         Prenatal development
         Immune system
         Microglia
         Maternal immune activation
         Immunology
         Internal Medicine
         Pathology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-024-01017-6/MediaObjects/281_2024_1017_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-024-01017-6/MediaObjects/281_2024_1017_Fig2_HTML.png
      isPartOf:
         name:Seminars in Immunopathology
         issn:
            1863-2300
            1863-2297
         volumeNumber:46
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:L. J. M. Mastenbroek
            affiliation:
                  name:University Medical Center Groningen, University of Groningen
                  address:
                     name:Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:S. M. Kooistra
            url:http://orcid.org/0000-0003-0211-8283
            affiliation:
                  name:University of Groningen
                  address:
                     name:Department of BioMedical Sciences, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:B. J. L. Eggen
            url:http://orcid.org/0000-0001-8941-0353
            affiliation:
                  name:University of Groningen
                  address:
                     name:Department of BioMedical Sciences, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:J. R. Prins
            url:http://orcid.org/0000-0002-3984-2163
            affiliation:
                  name:University Medical Center Groningen, University of Groningen
                  address:
                     name:Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Seminars in Immunopathology
      issn:
         1863-2300
         1863-2297
      volumeNumber:46
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University Medical Center Groningen, University of Groningen
      address:
         name:Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
         type:PostalAddress
      name:University of Groningen
      address:
         name:Department of BioMedical Sciences, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
         type:PostalAddress
      name:University of Groningen
      address:
         name:Department of BioMedical Sciences, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
         type:PostalAddress
      name:University Medical Center Groningen, University of Groningen
      address:
         name:Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:L. J. M. Mastenbroek
      affiliation:
            name:University Medical Center Groningen, University of Groningen
            address:
               name:Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
               type:PostalAddress
            type:Organization
      name:S. M. Kooistra
      url:http://orcid.org/0000-0003-0211-8283
      affiliation:
            name:University of Groningen
            address:
               name:Department of BioMedical Sciences, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
               type:PostalAddress
            type:Organization
      name:B. J. L. Eggen
      url:http://orcid.org/0000-0001-8941-0353
      affiliation:
            name:University of Groningen
            address:
               name:Department of BioMedical Sciences, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
               type:PostalAddress
            type:Organization
      name:J. R. Prins
      url:http://orcid.org/0000-0002-3984-2163
      affiliation:
            name:University Medical Center Groningen, University of Groningen
            address:
               name:Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
      name:Department of BioMedical Sciences, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
      name:Department of BioMedical Sciences, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
      name:Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

External Links {🔗}(456)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.64s.

LINK . SPRINGER . COM {}