We are analyzing https://link.springer.com/article/10.1007/s00281-013-0367-7.

Title:
Tumor-associated macrophages: functional diversity, clinical significance, and open questions | Seminars in Immunopathology
Description:
Inflammation is now a well-recognized hallmark of cancer progression. Tumor-associated macrophages (TAMs) are one of the major inflammatory cells that infiltrate murine and human tumors. While epidemiological studies indicate a clear correlation between TAM density and poor prognosis in a number of human cancers, transgenic studies and transcriptome profiling of TAMs in mice have established their crucial role in cancer progression. In fact, TAMs affect diverse aspects of cancer progression including tumor cell growth and survival, invasion, metastasis, angiogenesis, inflammation, and immunoregulation. New evidences have extended the repertoire of these cells to other tumor promoting activities like interactions with cancer stem cells, response to chemotherapy, and tumor relapse. These findings have triggered efforts to target TAMs and their associated molecules to modulate tumor progression. In particular, “re-education” to activate their anti-tumor potential or elimination of tumor promoting TAMs are strategies undergoing preclinical and clinical evaluation. Proof-of-principle studies indicate that TAM-centered therapeutic strategies may contribute to cancer therapy.
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Keywords {🔍}

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Topics {✒️}

anti-her2/neu antibody depends tumor-targeted interferon-alpha delivery month download article/chapter tumor-infiltrating tie2-expressing monocytes tumor-derived chemotactic factor myeloid-derived suppressor cells anti-cd47 antibody synergizes clodronate-liposome-mediated depletion tam-centered therapeutic strategies tnf-alpha involve tnfr1 c-fos proto-oncogene adenoma-linked barrier defects chemokine-mediated rapid turnover cytokine-driven compensatory proliferation macrophage tnf-alpha enhance dangerous menage-a-trois enhanced irf-3/stat1 activation tie2-expressing macrophages limit cancer stem/initiating cells il-12-initiated tumor regression proangiogenic tie2-expressing monocytes cd16-positive monocytes reveals colony-stimulating factor-1 colony stimulating factors murine peritoneal macrophages facilitate breast-tumour metastasis activate anti-tumor immunity promotes tumor growth full article pdf imaging tumor-stroma interactions myeloid cell biology strategies undergoing preclinical tie2-expressing monocytes mammary tumor-bearing mice enhances tumor response privacy choices/manage cookies proangiogenic myeloid cells linking microbial infections o'dwyer pj inflammatory dendritic cells myeloid cells independent promotes chemical hepatocarcinogenesis macrophage chemoattractant protein-1 chemokine receptor cxcr4 anti-tumor potential ccr2-dependent recruitment major inflammatory cells improves chemotherapeutic responses article biswas ikkbeta links inflammation

Questions {❓}

Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow?
Chan AT, Cook NR (2012) Are we ready to recommend aspirin for cancer prevention?

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      description:Inflammation is now a well-recognized hallmark of cancer progression. Tumor-associated macrophages (TAMs) are one of the major inflammatory cells that infiltrate murine and human tumors. While epidemiological studies indicate a clear correlation between TAM density and poor prognosis in a number of human cancers, transgenic studies and transcriptome profiling of TAMs in mice have established their crucial role in cancer progression. In fact, TAMs affect diverse aspects of cancer progression including tumor cell growth and survival, invasion, metastasis, angiogenesis, inflammation, and immunoregulation. New evidences have extended the repertoire of these cells to other tumor promoting activities like interactions with cancer stem cells, response to chemotherapy, and tumor relapse. These findings have triggered efforts to target TAMs and their associated molecules to modulate tumor progression. In particular, “re-education” to activate their anti-tumor potential or elimination of tumor promoting TAMs are strategies undergoing preclinical and clinical evaluation. Proof-of-principle studies indicate that TAM-centered therapeutic strategies may contribute to cancer therapy.
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