We are analyzing https://link.springer.com/article/10.1007/s00281-009-0169-0.

Title:
Mononuclear cells in liver fibrosis | Seminars in Immunopathology
Description:
Fibrosis is a multicellular wound healing process, where myofibroblasts that express extracellular matrix components extensively cross-talk with other cells resident in the liver or recruited from the bloodstream. Macrophages and infiltrating monocytes participate in the development of fibrosis via several mechanisms, including secretion of cytokines and generation of oxidative stress-related products. However, macrophages are also pivotal in the process of fibrosis resolution, where they contribute to matrix degradation. T lymphocytes modulate the fibrogenic process by direct interaction with myofibroblasts and secreting cytokines. In general, Th2 polarized responses promote fibrosis, while Th1 cytokines may be antifibrogenic. NK cells limit the development of fibrosis and favor its resolution, at least in part via killing of fibrogenic cells. The possible role of NKT cells and B cells is emerging in recent studies. Thus, mononuclear cells represent a critical regulatory system during fibrogenesis and may become an appealing target for therapy.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,016 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

google, scholar, pubmed, cas, article, cells, liver, fibrosis, hepatic, cell, hepatology, stellate, rat, activation, immunol, gastroenterology, clin, marra, macrophages, injury, kupffer, mice, role, human, chronic, matrix, fibrogenesis, invest, physiol, hepatitis, monocyte, cytokines, receptor, protein, expression, friedman, proliferation, hepatol, growth, biol, lymphocytes, nkt, fatstoring, regulation, exp, res, production, med, immune, wynn,

Topics {✒️}

schistosoma mansoni-infected baboons beta-glucosylceramide-mediated immune modulation platelet-derived growth factor' platelet-derived growth factor liver-resident antigen-presenting cells month download article/chapter interferon-gamma-mediated activation bile duct-ligated mouse t-lymphocyte-mediated stimulation graft-versus-host reaction oxidative stress-related products hcv-related liver disease hepatic ischemia-reperfusion injury monocyte chemotactic protein-1 alcohol-induced hepatic fibrosis apolipoprotein e-knockout mice oxidative stress-related molecules kupffer cell-mediated induction il-12-based vaccination method cultured human hepatocytes fat-storing cells mouse cd1-specific nk1 infiltrating monocytes participate hepatic stellate cells hepatic macrophages promote full article pdf stellate cell activation critical regulatory system natural killer activity invariant natural killer antigen-presenting cells induced hepatic fibrosis stimulate lymphocyte proliferation helper cytokine responses bile ducts induced alternatively activated macrophages privacy choices/manage cookies [corrected] kupffer cells nk cell recognition article marra extracellular matrix deposition chemokine-mediated control nk cells limit de bleser pj human liver disease rat hepatic lipocytes related subjects normal rat liver nkt lymphocyte distribution experimental hepatic fibrosis

Questions {❓}

Mosmann T (2000) Complexity or coherence?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Mononuclear cells in liver fibrosis
         description:Fibrosis is a multicellular wound healing process, where myofibroblasts that express extracellular matrix components extensively cross-talk with other cells resident in the liver or recruited from the bloodstream. Macrophages and infiltrating monocytes participate in the development of fibrosis via several mechanisms, including secretion of cytokines and generation of oxidative stress-related products. However, macrophages are also pivotal in the process of fibrosis resolution, where they contribute to matrix degradation. T lymphocytes modulate the fibrogenic process by direct interaction with myofibroblasts and secreting cytokines. In general, Th2 polarized responses promote fibrosis, while Th1 cytokines may be antifibrogenic. NK cells limit the development of fibrosis and favor its resolution, at least in part via killing of fibrogenic cells. The possible role of NKT cells and B cells is emerging in recent studies. Thus, mononuclear cells represent a critical regulatory system during fibrogenesis and may become an appealing target for therapy.
         datePublished:2009-06-17T00:00:00Z
         dateModified:2009-06-17T00:00:00Z
         pageStart:345
         pageEnd:358
         sameAs:https://doi.org/10.1007/s00281-009-0169-0
         keywords:
            Liver fibrosis
            Hepatic stellate cells
            Kupffer cells
            Macrophages
            Monocytes
            T lymphocytes
            B lymphocytes
            NK cells
            NKT cells
            Chemokines
            Immunology
            Internal Medicine
            Pathology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-009-0169-0/MediaObjects/281_2009_169_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-009-0169-0/MediaObjects/281_2009_169_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-009-0169-0/MediaObjects/281_2009_169_Fig3_HTML.gif
         isPartOf:
            name:Seminars in Immunopathology
            issn:
               1863-2300
               1863-2297
            volumeNumber:31
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Fabio Marra
               affiliation:
                     name:University of Florence
                     address:
                        name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
                        type:PostalAddress
                     type:Organization
                     name:University of Florence
                     address:
                        name:Center for Research, Transfer and Higher Education ‘DenoTHE’, University of Florence, Florence, Italy
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Sara Aleffi
               affiliation:
                     name:University of Florence
                     address:
                        name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sara Galastri
               affiliation:
                     name:University of Florence
                     address:
                        name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Angela Provenzano
               affiliation:
                     name:University of Florence
                     address:
                        name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Mononuclear cells in liver fibrosis
      description:Fibrosis is a multicellular wound healing process, where myofibroblasts that express extracellular matrix components extensively cross-talk with other cells resident in the liver or recruited from the bloodstream. Macrophages and infiltrating monocytes participate in the development of fibrosis via several mechanisms, including secretion of cytokines and generation of oxidative stress-related products. However, macrophages are also pivotal in the process of fibrosis resolution, where they contribute to matrix degradation. T lymphocytes modulate the fibrogenic process by direct interaction with myofibroblasts and secreting cytokines. In general, Th2 polarized responses promote fibrosis, while Th1 cytokines may be antifibrogenic. NK cells limit the development of fibrosis and favor its resolution, at least in part via killing of fibrogenic cells. The possible role of NKT cells and B cells is emerging in recent studies. Thus, mononuclear cells represent a critical regulatory system during fibrogenesis and may become an appealing target for therapy.
      datePublished:2009-06-17T00:00:00Z
      dateModified:2009-06-17T00:00:00Z
      pageStart:345
      pageEnd:358
      sameAs:https://doi.org/10.1007/s00281-009-0169-0
      keywords:
         Liver fibrosis
         Hepatic stellate cells
         Kupffer cells
         Macrophages
         Monocytes
         T lymphocytes
         B lymphocytes
         NK cells
         NKT cells
         Chemokines
         Immunology
         Internal Medicine
         Pathology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-009-0169-0/MediaObjects/281_2009_169_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-009-0169-0/MediaObjects/281_2009_169_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-009-0169-0/MediaObjects/281_2009_169_Fig3_HTML.gif
      isPartOf:
         name:Seminars in Immunopathology
         issn:
            1863-2300
            1863-2297
         volumeNumber:31
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Fabio Marra
            affiliation:
                  name:University of Florence
                  address:
                     name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
                     type:PostalAddress
                  type:Organization
                  name:University of Florence
                  address:
                     name:Center for Research, Transfer and Higher Education ‘DenoTHE’, University of Florence, Florence, Italy
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Sara Aleffi
            affiliation:
                  name:University of Florence
                  address:
                     name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sara Galastri
            affiliation:
                  name:University of Florence
                  address:
                     name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Angela Provenzano
            affiliation:
                  name:University of Florence
                  address:
                     name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Seminars in Immunopathology
      issn:
         1863-2300
         1863-2297
      volumeNumber:31
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Florence
      address:
         name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
         type:PostalAddress
      name:University of Florence
      address:
         name:Center for Research, Transfer and Higher Education ‘DenoTHE’, University of Florence, Florence, Italy
         type:PostalAddress
      name:University of Florence
      address:
         name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
         type:PostalAddress
      name:University of Florence
      address:
         name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
         type:PostalAddress
      name:University of Florence
      address:
         name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Fabio Marra
      affiliation:
            name:University of Florence
            address:
               name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
               type:PostalAddress
            type:Organization
            name:University of Florence
            address:
               name:Center for Research, Transfer and Higher Education ‘DenoTHE’, University of Florence, Florence, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Sara Aleffi
      affiliation:
            name:University of Florence
            address:
               name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
               type:PostalAddress
            type:Organization
      name:Sara Galastri
      affiliation:
            name:University of Florence
            address:
               name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
               type:PostalAddress
            type:Organization
      name:Angela Provenzano
      affiliation:
            name:University of Florence
            address:
               name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
      name:Center for Research, Transfer and Higher Education ‘DenoTHE’, University of Florence, Florence, Italy
      name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
      name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
      name:Dipartimento di Medicina Interna, University of Florence, Florence, Italy
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(382)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.55s.

LINK . SPRINGER . COM {}