We are analyzing https://link.springer.com/article/10.1007/s002800050850.

Title:
Jasplakinolide: interaction with radiation and hyperthermia in human prostate carcinoma and Lewis lung carcinoma | Cancer Chemotherapy and Pharmacology
Description:
Purpose: Jasplakinolide is a novel natural product anticancer agent which acts by inducing over-polymerization of actin. The aim of the current study was to explore the activity of jasplakinolide with hyperthermia and radiation. Methods: The response of human PC-3 and DU-145 prostate carcinoma cells and DU-145 xenografts and the response of the Lewis lung carcinoma to jasplakinolide were studied. Results: Jasplakinolide was cytotoxic toward human prostate carcinoma cells, DU-145, PC-3 and LNCaP in culture, killing 1 log of cells with 0.8, 0.3 and 0.07 m of drug in 24 h, respectively. The combination of jasplakinolide and hyperthermia resulted in primarily additive cell killing by the two modalities in the three prostate carcinoma lines. In combination with radiation, jasplakinolide produced some diminution in the shoulder of the survival curve of normally oxygenated PC-3 cells and was a radiation sensitizer of hypoxic DU-145 cells and hypoxic PC-3 cells. In vivo, jasplakinolide was an active antitumor agent against the Lewis lung carcinoma and the DU-145 prostate carcinoma xenograft. Jasplakinolide was a radiation sensitizer in the Lewis lung carcinoma. Jasplakinolide was also effective against the systemic Lewis lung carcinoma, decreasing lung metastases. Lung metastases were further decreased when jasplakinolide was administered along with radiation to the subcutaneous primary tumor. In the DU-145 tumor, the effects of jasplakinolide and fractionated radiation for 1 or 2 weeks appeared to be primarily additive. Conclusion: Jasplakinolide is an interesting new anticancer agent for which further study both as an anticancer agent and in combined modality regimens is warranted.
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jasplakinolide, carcinoma, article, radiation, cancer, prostate, lung, cells, access, lewis, privacy, cookies, content, hyperthermia, information, log, publish, search, human, agent, open, data, journal, research, chemotherapy, takeuchi, ara, sausville, explore, anticancer, hypoxic, discover, usa, springer, optional, personal, parties, policy, find, track, pharmacology, interaction, cite, hideya, gulshan, edward, beverly, teicher, study, response,

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article cancer chemotherapy month download article/chapter national cancer institute human prostate carcinoma prostate carcinoma lines related subjects lewis lung carcinoma privacy choices/manage cookies full article pdf radiation therapy decreasing lung metastases check access instant access hypoxic du-145 cells oxygenated pc-3 cells european economic area combined modality regimens hypoxic pc-3 cells active antitumor agent conditions privacy policy subcutaneous primary tumor cancer treatment accepting optional cookies gulshan ara article takeuchi journal finder publish article log du-145 xenografts lung metastases hideya takeuchi article cite primarily additive privacy policy explore personal data books a anticancer agent radiation sensitizer fractionated radiation human pc-3 killing 1 log du-145 tumor optional cookies manage preferences hyperthermia resulted subscription content similar content information data protection hypoxic stress

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         headline:Jasplakinolide: interaction with radiation and hyperthermia in human prostate carcinoma and Lewis lung carcinoma
         description: Purpose: Jasplakinolide is a novel natural product anticancer agent which acts by inducing over-polymerization of actin. The aim of the current study was to explore the activity of jasplakinolide with hyperthermia and radiation. Methods: The response of human PC-3 and DU-145 prostate carcinoma cells and DU-145 xenografts and the response of the Lewis lung carcinoma to jasplakinolide were studied. Results: Jasplakinolide was cytotoxic toward human prostate carcinoma cells, DU-145, PC-3 and LNCaP in culture, killing 1 log of cells with 0.8, 0.3 and 0.07 m of drug in 24 h, respectively. The combination of jasplakinolide and hyperthermia resulted in primarily additive cell killing by the two modalities in the three prostate carcinoma lines. In combination with radiation, jasplakinolide produced some diminution in the shoulder of the survival curve of normally oxygenated PC-3 cells and was a radiation sensitizer of hypoxic DU-145 cells and hypoxic PC-3 cells. In vivo, jasplakinolide was an active antitumor agent against the Lewis lung carcinoma and the DU-145 prostate carcinoma xenograft. Jasplakinolide was a radiation sensitizer in the Lewis lung carcinoma. Jasplakinolide was also effective against the systemic Lewis lung carcinoma, decreasing lung metastases. Lung metastases were further decreased when jasplakinolide was administered along with radiation to the subcutaneous primary tumor. In the DU-145 tumor, the effects of jasplakinolide and fractionated radiation for 1 or 2 weeks appeared to be primarily additive. Conclusion: Jasplakinolide is an interesting new anticancer agent for which further study both as an anticancer agent and in combined modality regimens is warranted.
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      headline:Jasplakinolide: interaction with radiation and hyperthermia in human prostate carcinoma and Lewis lung carcinoma
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      dateModified:
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