We are analyzing https://link.springer.com/article/10.1007/s00280-016-3213-5.

Title:
Use of retinoic acid/aldehyde dehydrogenase pathway as potential targeted therapy against cancer stem cells | Cancer Chemotherapy and Pharmacology
Description:
A large number of studies have investigated possible drug resistance mechanisms of cancer cells and suggested strategies to overcome it. In this review, we outline the role and function of aldehyde dehydrogenase (ALDH) activity in multiple cellular functions and in cancer stem cells (CSCs) and focus on the role of retinoic acid (RA), one of the products of ALDH isozymes. We discuss our observation that ATRA and other RAs can suppress ALDH activity and decrease different ALDH isozyme proteins and result in detrimental effects on cell proliferation, invasion and chemotherapy sensitivity. We review the known uses of different RAs in the treatment of cancers. We review the use of RAs in combination with chemo-/radiotherapy and the major signaling pathways affected in different tumor types. We provide follow-up on studies that may have used our prior observation with the aim of targeting the CSCs. We conclude with summary of the findings and potential impact of published studies on future use of RAs in the targeting of CSCs and drug resistance.
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Keywords {🔍}

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Topics {✒️}

month download article/chapter cd133+ tumor-initiating cells aids-related cutaneous kaposi enhances dexamethasone-induced cytotoxicity therapy-resistant cancer cells c-myc antisense dna peroxisome proliferator-activated receptor small-cell lung cancer downregulating c-myc expression aldehyde dehydrogenase class-1a1 article cancer chemotherapy potential targeted therapy drug-resistant lung cancer trans retinoic acid trans-retinoic acid cancer stem cells high-dose combination chemotherapy ovarian cancer cells cellular retinoid-binding proteins full article pdf cancer therapeutics retinoic acid biosynthesis 13-cis-retinoic acid 9-cis-retinoic acid growth factor support stem cell properties human aldehyde dehydrogenase selectively targeting aldh-high retinoic acid receptors acute myeloid leukemia aldehyde dehydrogenase expression acute promyelocytic leukemia inhibits tumour formation privacy choices/manage cookies multiple myeloma cells regulates aldehyde dehydrogenase aldehyde dehydrogenase inhibitors article moreb rnai-mediated knockdown leukemic blasts defines metastatic breast cancer human aldehyde dehydrogenases aldehyde dehydrogenase gene aldehyde dehydrogenase activity randomized controlled trial moreb js author correspondence related subjects aldehyde dehydrogenase superfamily activity reduces chemotherapy

Questions {❓}

Pors K, Moreb JS (2014) Aldehyde dehydrogenases in cancer: an opportunity for biomarker and drug development?

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         description:A large number of studies have investigated possible drug resistance mechanisms of cancer cells and suggested strategies to overcome it. In this review, we outline the role and function of aldehyde dehydrogenase (ALDH) activity in multiple cellular functions and in cancer stem cells (CSCs) and focus on the role of retinoic acid (RA), one of the products of ALDH isozymes. We discuss our observation that ATRA and other RAs can suppress ALDH activity and decrease different ALDH isozyme proteins and result in detrimental effects on cell proliferation, invasion and chemotherapy sensitivity. We review the known uses of different RAs in the treatment of cancers. We review the use of RAs in combination with chemo-/radiotherapy and the major signaling pathways affected in different tumor types. We provide follow-up on studies that may have used our prior observation with the aim of targeting the CSCs. We conclude with summary of the findings and potential impact of published studies on future use of RAs in the targeting of CSCs and drug resistance.
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      description:A large number of studies have investigated possible drug resistance mechanisms of cancer cells and suggested strategies to overcome it. In this review, we outline the role and function of aldehyde dehydrogenase (ALDH) activity in multiple cellular functions and in cancer stem cells (CSCs) and focus on the role of retinoic acid (RA), one of the products of ALDH isozymes. We discuss our observation that ATRA and other RAs can suppress ALDH activity and decrease different ALDH isozyme proteins and result in detrimental effects on cell proliferation, invasion and chemotherapy sensitivity. We review the known uses of different RAs in the treatment of cancers. We review the use of RAs in combination with chemo-/radiotherapy and the major signaling pathways affected in different tumor types. We provide follow-up on studies that may have used our prior observation with the aim of targeting the CSCs. We conclude with summary of the findings and potential impact of published studies on future use of RAs in the targeting of CSCs and drug resistance.
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