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Keywords {🔍}

article, patients, chemotherapy, gmcsf, access, department, privacy, cookies, content, myelodysplastic, germany, data, information, publish, search, syndromes, recovery, university, log, journal, research, hematology, highrisk, verbeek, wörmann, koch, factor, cell, open, discover, hematologyoncology, springer, optional, analysis, personal, parties, policy, find, track, annals, sham, induction, cite, aul, hinrichs, balleisen, rowe, bennett, büchner, hiddemann,

Topics {✒️}

high-risk myelodysplastic syndromes sequential high-dose ara s-ham induction chemotherapy granulocyte colony-stimulating factor month download article/chapter high early-death rate prognostic subgroups showed related subjects full article pdf privacy choices/manage cookies low cr rate priming factor european economic area scope submit manuscript 250 μg/m2 starting 48 check access instant access conditions privacy policy georg-august university westfalen wilhelms university heinrich-heine university article annals accepting optional cookies intensified treatment approach network meta-analysis ten patients reached ten patients died complete hematologic recovery rochester medical center journal finder publish article log hematology aims median remission duration hematology/oncology gm-csf /mitoxantrone chemotherapy article cite article verbeek privacy policy dose information hiddemann department books a early death personal data g-csf optional cookies manage preferences complete remission subscription content

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         headline:S-HAM induction chemotherapy with or without GM-CSF in patients with high-risk myelodysplastic syndromes
         description: Thirty-one adult patients with high-risk myelodysplastic syndromes (MDS) were enrolled in a prospective randomized double-blind placebo-controlled trial evaluating the efficacy of sequential high-dose Ara C/mitoxantrone chemotherapy with or without GM-CSF. GM-CSF or placebo was given subcutaneously once daily at a dose of 250 μg/m2 starting 48 h prior to chemotherapy and continued until neutrophil recovery. This design allowed us to investigate the role of GM-CSF as a priming factor for the leukemic clone, as well as its effect on the recovery of normal hematopoiesis. Twenty-eight patients are currently evaluable for response. Ten patients reached a complete remission (36%), eight patients had persistent MDS (29%), and ten patients died within 6 weeks after the onset of treatment (early death). Infectious complications during cytopenia were the major cause of death (8/10). Median time to complete hematologic recovery (neutrophils >500/μl and platelets 20 000/μl) and time to neutrophil recovery above 1500/μl was 29 and 35 days, respectively. Median remission duration was 190 days (6.4 months). Analysis of prognostic subgroups showed a low CR rate (25%) and a high early-death rate (44%) in patients >55 years of age, suggesting that the intensified treatment approach should be limited to younger patients. No data concerning the influence of GM-CSF on response to chemotherapy or duration of neutropenia are presently available.
         datePublished:
         dateModified:
         pageStart:205
         pageEnd:208
         sameAs:https://doi.org/10.1007/s002770050285
         keywords:
            Key words Myelodysplastic syndromes
            High-dose cytosine arabinoside
            GM-CSF
            Hematology
            Oncology
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                        name:Department of Hematology/Oncology, Georg-August University, Göttingen, Germany, , DE
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                     name:Department of Medical Oncology, University of Rochester Medical Center, Rochester, NY, USA
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      headline:S-HAM induction chemotherapy with or without GM-CSF in patients with high-risk myelodysplastic syndromes
      description: Thirty-one adult patients with high-risk myelodysplastic syndromes (MDS) were enrolled in a prospective randomized double-blind placebo-controlled trial evaluating the efficacy of sequential high-dose Ara C/mitoxantrone chemotherapy with or without GM-CSF. GM-CSF or placebo was given subcutaneously once daily at a dose of 250 μg/m2 starting 48 h prior to chemotherapy and continued until neutrophil recovery. This design allowed us to investigate the role of GM-CSF as a priming factor for the leukemic clone, as well as its effect on the recovery of normal hematopoiesis. Twenty-eight patients are currently evaluable for response. Ten patients reached a complete remission (36%), eight patients had persistent MDS (29%), and ten patients died within 6 weeks after the onset of treatment (early death). Infectious complications during cytopenia were the major cause of death (8/10). Median time to complete hematologic recovery (neutrophils >500/μl and platelets 20 000/μl) and time to neutrophil recovery above 1500/μl was 29 and 35 days, respectively. Median remission duration was 190 days (6.4 months). Analysis of prognostic subgroups showed a low CR rate (25%) and a high early-death rate (44%) in patients >55 years of age, suggesting that the intensified treatment approach should be limited to younger patients. No data concerning the influence of GM-CSF on response to chemotherapy or duration of neutropenia are presently available.
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      dateModified:
      pageStart:205
      pageEnd:208
      sameAs:https://doi.org/10.1007/s002770050285
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         Key words Myelodysplastic syndromes
         High-dose cytosine arabinoside
         GM-CSF
         Hematology
         Oncology
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            name:W. Verbeek
            affiliation:
                  name:Department of Hematology/Oncology, Georg-August University, Göttingen, Germany
                  address:
                     name:Department of Hematology/Oncology, Georg-August University, Göttingen, Germany, , DE
                     type:PostalAddress
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            name:B. Wörmann
            affiliation:
                  name:Department of Hematology/Oncology, Georg-August University, Göttingen, Germany
                  address:
                     name:Department of Hematology/Oncology, Georg-August University, Göttingen, Germany, , DE
                     type:PostalAddress
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                  name:Department of Hematology/Oncology, Westfalen Wilhelms University, Münster, Germany
                  address:
                     name:Department of Hematology/Oncology, Westfalen Wilhelms University, Münster, Germany, , DE
                     type:PostalAddress
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            name:C. Aul
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                     name:Department of Hematology/Oncology, Heinrich-Heine University, Düsseldorf, Germany, , DE
                     type:PostalAddress
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            name:Department of Hematology/Oncology, Westfalen Wilhelms University, Münster, Germany
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               name:Department of Hematology/Oncology, Westfalen Wilhelms University, Münster, Germany, , DE
               type:PostalAddress
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      name:C. Aul
      affiliation:
            name:Department of Hematology/Oncology, Heinrich-Heine University, Düsseldorf, Germany
            address:
               name:Department of Hematology/Oncology, Heinrich-Heine University, Düsseldorf, Germany, , DE
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               name:Department of Internal Medicine, Evangelisches Krankenhaus, Oldenburg, Germany, , DE
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               name:Department of Internal Medicine, Evangelisches Krankenhaus, Hamm, Germany, , DE
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               name:Department of Medical Oncology, University of Rochester Medical Center, Rochester, NY, USA, , US
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               name:Department of Medical Oncology, University of Rochester Medical Center, Rochester, NY, USA, , US
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            name:Department of Hematology/Oncology, Westfalen Wilhelms University, Münster, Germany
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               name:Department of Hematology/Oncology, Westfalen Wilhelms University, Münster, Germany, , DE
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            name:Department of Hematology/Oncology, Georg-August University, Göttingen, Germany
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               name:Department of Hematology/Oncology, Georg-August University, Göttingen, Germany, , DE
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      name:Department of Hematology/Oncology, Westfalen Wilhelms University, Münster, Germany, , DE
      name:Department of Hematology/Oncology, Heinrich-Heine University, Düsseldorf, Germany, , DE
      name:Department of Internal Medicine, Evangelisches Krankenhaus, Oldenburg, Germany, , DE
      name:Department of Internal Medicine, Evangelisches Krankenhaus, Hamm, Germany, , DE
      name:Department of Medical Oncology, University of Rochester Medical Center, Rochester, NY, USA, , US
      name:Department of Medical Oncology, University of Rochester Medical Center, Rochester, NY, USA, , US
      name:Department of Hematology/Oncology, Westfalen Wilhelms University, Münster, Germany, , DE
      name:Department of Hematology/Oncology, Georg-August University, Göttingen, Germany, , DE
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