We are analyzing https://link.springer.com/article/10.1007/s00277-004-0855-x.

Title:
Assessment of biological prognostic factors provides clinically relevant information in patients with diffuse large B-cell lymphoma—a Nordic Lymphoma Group study | Annals of Hematology
Description:
The purpose of this study was to investigate the prognostic effects of four biological markers, BCL2, TP53, Ki-67, and P-glycoprotein, and their possible clinical relevance in addition to the international prognostic index (IPI) in diffuse large B-cell lymphoma (DLBCL). A total of 405 patients with aggressive lymphoma, stage II-IV, between 18 and 67 years, were randomized in a trial comparing CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin). Of these, 267 cases were classified as DLBCL, with adequate paraffin blocks available in 207 cases, enabling immunohistochemical assessment of the expression of BCL2, TP53, P-glycoprotein, and Ki-67. In a multivariate analysis, stratified for IPI, high BCL2 expression (>10%) low (<60%) expression of Ki-67, and high TP53 protein expression (>75%) were shown to provide additional prognostic information with regard to overall or failure-free survival. We found no association between expression of P-glycoprotein and outcome. Assessment of BCL2 positivity might be introduced as part of the routine investigation in patients with DLBCL, but further studies are necessary to confirm the clinical relevance of Ki-67 and TP53 expression.
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Topics {✒️}

month download article/chapter high-grade b-cell lymphomas international prognostic index cell-cycle regulator proteins aggressive b-cell lymphoma diffuse large cell b-cell lymphoma trial comparing chop biological prognostic factors chop versus macop full article pdf privacy choices/manage cookies lymphoma classification project related subjects b-cell cavallin-ståhl department high-grade osteosarcomas bcl-2 gene rearrangement major histologic subtypes epoch chemotherapy elisabeth nilsson foundation population-based study european economic area scope submit manuscript stage ii-iv adequate paraffin blocks human normal tissues tumor proliferation expert technical assistance norwegian radium hospital conditions privacy policy check access gela-lnh87 trial instant access high bcl2 expression clinically relevant information van krieken jh article annals swedish cancer society bcl-2 protein expression kluin-nelemans jc biological markers accepting optional cookies failure-free survival author information authors martinez-montero jc clinical drug resistance p53 protein expression journal finder publish p-glycoprotein

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