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media/news-center/press-releases/detail/196/adaptimmune-updates-data α-fetoprotein-specific t-cell receptors jinlin hou & de-ke jiang ny-eso-1-reactive t-cell receptor elicit t-cell-mediated immunity affinity-improved-tcr engineered t-cells specific t-cell receptor t-cell receptor specific image-guided tumor ablation t-cell receptor-engineered ny-eso-1 cancer-testis antigens ny-eso-1-specific tcr-engineered frameshift-mutation-derived peptides pbmc-based approach involves adoptive t-cell therapy de-ke jiang pd-1/pd-l1 axis post-transplantation hbv-hcc patient pre-existing antigen-specific gold-standard data classification tcr-t-targeted killing recurrent hcc post-transplantation article download pdf including high-throughput sequencing hpv-positive oropharyngeal cancer doxorubicin-eluting-bead embolization alpha-fetoprotein alt short lived hbv-tcr tcr-based cellular immunotherapy resistant hbs183-specific tcr ras-mutated peptide targeted t-cell receptor consistently demonstrated ny-eso-1 reduced treatment-related toxicity hand–foot skin reactions produce pro-inflammatory cytokines inter-observer variability study ny-eso-1-specific tcr melanoma-specific antigen recognized regional long-term survival epitope peptide-specific tcrs hbv-related hepatocellular carcinoma small-cell lung cancer antibody-producing plasma cells intermediate-stage hepatocellular carcinoma neoantigen-targeted therapies remain retrovirus-mediated gene therapy vaccine-induced antigen presentation tumour-infiltrating lymphocytes predict chimeric antigen receptor

Questions {❓}

• Key questions remain: Are these mutations hindered by low transcription or translation efficiency in cancer cells?

Schema {🗺️}

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         headline:TCR-based cellular immunotherapy for hepatocellular carcinoma: advances, challenges, and prospects
         description:Hepatocellular carcinoma (HCC) ranks among the most prevalent malignant tumors globally. However, current frontline treatment modalities fail to achieve satisfactory therapeutic outcomes. In recent years, T-cell receptor (TCR)-T therapy has garnered increasing attention as a promising therapeutic approach. This review provides an overview of the epidemiology of HCC, evaluates the efficacy of current first-line treatment options, and introduces adoptive cellular therapies (ACTs), with a specific focus on TCR-T therapy. Notably, we categorize existing TCR-T research targeting different antigens for the treatment of HCC, covering both published literature and registered clinical trials. Furthermore, we discuss the limitations of current TCR-T research and applications, while offering insights into future research directions and development prospects. In summary, this review comprehensively examines the research progress on TCR-T therapy for HCC from the perspective of antigen targeting. Although several challenges remain to be addressed, we believe that TCR-T therapy represents a promising approach for the treatment of HCC.
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      headline:TCR-based cellular immunotherapy for hepatocellular carcinoma: advances, challenges, and prospects
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      name:State Key Laboratory of Organ Failure Research, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases, Guangdong Provincial Clinical Research Center for Viral Hepatitis, Guangdong Institute of Hepatology, Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China
      name:State Key Laboratory of Organ Failure Research, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases, Guangdong Provincial Clinical Research Center for Viral Hepatitis, Guangdong Institute of Hepatology, Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China
      name:State Key Laboratory of Organ Failure Research, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases, Guangdong Provincial Clinical Research Center for Viral Hepatitis, Guangdong Institute of Hepatology, Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China
      name:The Key Laboratory of Molecular Pathology (Hepatic Diseases) of Guangxi, Department of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China

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