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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s00262-023-03516-1.

Title:
TIM-3 as a promising target for cancer immunotherapy in a wide range of tumors | Cancer Immunology, Immunotherapy
Description:
T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) expression has been a trending topic in recent years due to its differential expression in a wide range of neoplasms. TIM-3 is one of the key immune checkpoint receptors that interact with GAL-9, PtdSer, HMGB1 and CEACAM1. Initially identified on the surface of T helper 1 (Th1) lymphocytes and later on cytotoxic lymphocytes (CTLs), monocytes, macrophages, natural killer cells (NKs), and dendritic cells (DCs), TIM-3 plays a key role in immunoregulation. Recently, a growing body of evidence has shown that its differential expression in various tumor types indicates a specific prognosis for cancer patients. Here, we discuss which types of cancer TIM-3 can serve as a prognostic factor and the influence of coexpressed immune checkpoint inhibitors, such as LAG-3, PD-1, and CTLA-4 on patients
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

tim, cells, cancer, expression, pubmed, article, cell, google, scholar, immune, tumor, cas, patients, study, central, tumors, function, response, immunol, human, carcinoma, clinical, antitim, antibody, antibodies, blockade, tcell, activation, immunotherapy, role, signaling, advanced, target, shown, res, protein, antitumor, combination, solid, gal, increased, checkpoint, ceacam, lag, survival, accessed, online, prognosis, domain, levels,

Topics {✒️}

5700616/attachment/fe29be34-b63b-4d1b-a7c2-e1ff6979d27b/mmc1 lymphomas—full text view—clinicaltrials neck—full text view—clinicaltrials anti-tim-3/anti-pd-l1 bispecific antibody tumor-induced ny-eso-1-specific cd8 + full text view—clinicaltrials tumor-infiltrating b-cell supernatant tim-3 + pd-1 + ny-eso-1-specific cd8 + anti-tim-3 targeted therapies lps/tlr4-induced pro-inflammatory response cd8 + t-cell functions improved anti-pd-l1 triggered overexpression /glial-tim-3-modulates-immune-responses myeloid-derived suppressor cells anaplastic-thyroid-cancer-infiltrating macrophages /phase-i-ib-clinical-trial sequentially tumor-selected antibody anti-tim-3/anti-pd-1 antibodies cell-based therapies anti-inflammatory/pro-tumorigenic phenotype potentiates fcεri-proximal signaling article download pdf attenuate gal-9/tim-3-induced apoptosis anti-pd-1/anti-tim-3 blockade mitogen-activated protein kinase t-bet mrna expression glioma cell-intrinsic tim-3 pd-1/pd-l1 blockade upregulate t-cell immunoglobulin domain t-cell-deficient mice nf-κb/il-6/stat3 axis t-cell ratio predicts restore anti-tumor immunity marked t-cell activation anti-tim-3 bispecific focus highly dysfunctional tumor-induced suppresses cell-mediated cytotoxicity transcription factor t-bet anti-tim-3 monoclonal antibodies monoclonal anti-tim-3 antibodies restored anti-tumor immunity triple-negative breast cancer insights fromsingle-cell analysis galectin-9-induced cell death ccl4-induced mouse model cd8 + t-cell dysfunction fyn-jak1-znf384 pathways anti-tim3 antibody promotes anti-cancer therapeutic strategies enhancing anti-tumor activity

Questions {❓}

  • Ganjalikhani Hakemi M, Jafarinia M, Azizi M, Rezaeepoor M, Isayev O, Bazhin AV (2020) The role of TIM-3 in hepatocellular carcinoma: a promising target for immunotherapy?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:TIM-3 as a promising target for cancer immunotherapy in a wide range of tumors
         description:T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) expression has been a trending topic in recent years due to its differential expression in a wide range of neoplasms. TIM-3 is one of the key immune checkpoint receptors that interact with GAL-9, PtdSer, HMGB1 and CEACAM1. Initially identified on the surface of T helper 1 (Th1) lymphocytes and later on cytotoxic lymphocytes (CTLs), monocytes, macrophages, natural killer cells (NKs), and dendritic cells (DCs), TIM-3 plays a key role in immunoregulation. Recently, a growing body of evidence has shown that its differential expression in various tumor types indicates a specific prognosis for cancer patients. Here, we discuss which types of cancer TIM-3 can serve as a prognostic factor and the influence of coexpressed immune checkpoint inhibitors, such as LAG-3, PD-1, and CTLA-4 on patients' outcomes. Currently, experimental medicine involving TIM-3 has significantly enhanced the anti-tumor effect and improved patient survival. In this work, we summarized clinical trials incorporating TIM-3 targeting monoclonal and bispecific antibodies in monotherapy and combination therapy and highlighted the emerging role of cell-based therapies.
         datePublished:2023-08-11T00:00:00Z
         dateModified:2023-08-11T00:00:00Z
         pageStart:3405
         pageEnd:3425
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s00262-023-03516-1
         keywords:
            Cancer
            Immunotherapy
            TIM-3
            T-cells
            Oncology
            Immunology
            Cancer Research
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               0340-7004
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                        name:Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland
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                     address:
                        name:Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland
                        type:PostalAddress
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                     address:
                        name:State Research Institute Centre for Innovative Medicine, Department of Immunology, Vilnius, Lithuania
                        type:PostalAddress
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                     name:Wroclaw Medical University
                     address:
                        name:Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
                        type:PostalAddress
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                     name:State Research Institute Centre for Innovative Medicine, Department of Immunology
                     address:
                        name:State Research Institute Centre for Innovative Medicine, Department of Immunology, Vilnius, Lithuania
                        type:PostalAddress
                     type:Organization
                     name:Vilnius Gediminas Technical University
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                        name:Faculty of Electronics, Vilnius Gediminas Technical University, Vilnius, Lithuania
                        type:PostalAddress
                     type:Organization
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               name:Katarzyna Karłowicz-Bodalska
               affiliation:
                     name:Wroclaw Medical University
                     address:
                        name:Department of Drug Technology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
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ScholarlyArticle:
      headline:TIM-3 as a promising target for cancer immunotherapy in a wide range of tumors
      description:T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) expression has been a trending topic in recent years due to its differential expression in a wide range of neoplasms. TIM-3 is one of the key immune checkpoint receptors that interact with GAL-9, PtdSer, HMGB1 and CEACAM1. Initially identified on the surface of T helper 1 (Th1) lymphocytes and later on cytotoxic lymphocytes (CTLs), monocytes, macrophages, natural killer cells (NKs), and dendritic cells (DCs), TIM-3 plays a key role in immunoregulation. Recently, a growing body of evidence has shown that its differential expression in various tumor types indicates a specific prognosis for cancer patients. Here, we discuss which types of cancer TIM-3 can serve as a prognostic factor and the influence of coexpressed immune checkpoint inhibitors, such as LAG-3, PD-1, and CTLA-4 on patients' outcomes. Currently, experimental medicine involving TIM-3 has significantly enhanced the anti-tumor effect and improved patient survival. In this work, we summarized clinical trials incorporating TIM-3 targeting monoclonal and bispecific antibodies in monotherapy and combination therapy and highlighted the emerging role of cell-based therapies.
      datePublished:2023-08-11T00:00:00Z
      dateModified:2023-08-11T00:00:00Z
      pageStart:3405
      pageEnd:3425
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s00262-023-03516-1
      keywords:
         Cancer
         Immunotherapy
         TIM-3
         T-cells
         Oncology
         Immunology
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-023-03516-1/MediaObjects/262_2023_3516_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-023-03516-1/MediaObjects/262_2023_3516_Fig2_HTML.png
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         name:Cancer Immunology, Immunotherapy
         issn:
            1432-0851
            0340-7004
         volumeNumber:72
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
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      author:
            name:Natalia Sauer
            affiliation:
                  name:Wroclaw Medical University
                  address:
                     name:Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Natalia Janicka
            affiliation:
                  name:Wroclaw Medical University
                  address:
                     name:Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wojciech Szlasa
            affiliation:
                  name:Wroclaw Medical University
                  address:
                     name:Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bartłomiej Skinderowicz
            affiliation:
                  name:Wroclaw University of Science and Technology
                  address:
                     name:Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Katarzyna Kołodzińska
            affiliation:
                  name:Wroclaw University of Science and Technology
                  address:
                     name:Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wioletta Dwernicka
            affiliation:
                  name:Poznan University of Medical Sciences
                  address:
                     name:Faculty of Medicine, Poznan University of Medical Sciences, Poznan, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Małgorzata Oślizło
            affiliation:
                  name:Wroclaw Medical University
                  address:
                     name:Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Julita Kulbacka
            affiliation:
                  name:State Research Institute Centre for Innovative Medicine, Department of Immunology
                  address:
                     name:State Research Institute Centre for Innovative Medicine, Department of Immunology, Vilnius, Lithuania
                     type:PostalAddress
                  type:Organization
                  name:Wroclaw Medical University
                  address:
                     name:Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Vitalij Novickij
            affiliation:
                  name:State Research Institute Centre for Innovative Medicine, Department of Immunology
                  address:
                     name:State Research Institute Centre for Innovative Medicine, Department of Immunology, Vilnius, Lithuania
                     type:PostalAddress
                  type:Organization
                  name:Vilnius Gediminas Technical University
                  address:
                     name:Faculty of Electronics, Vilnius Gediminas Technical University, Vilnius, Lithuania
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Katarzyna Karłowicz-Bodalska
            affiliation:
                  name:Wroclaw Medical University
                  address:
                     name:Department of Drug Technology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
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      name:Cancer Immunology, Immunotherapy
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      volumeNumber:72
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      name:Springer Berlin Heidelberg
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      name:Wroclaw Medical University
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      address:
         name:Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
         type:PostalAddress
      name:Wroclaw Medical University
      address:
         name:Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland
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      address:
         name:Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland
         type:PostalAddress
      name:Wroclaw University of Science and Technology
      address:
         name:Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland
         type:PostalAddress
      name:Poznan University of Medical Sciences
      address:
         name:Faculty of Medicine, Poznan University of Medical Sciences, Poznan, Poland
         type:PostalAddress
      name:Wroclaw Medical University
      address:
         name:Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland
         type:PostalAddress
      name:State Research Institute Centre for Innovative Medicine, Department of Immunology
      address:
         name:State Research Institute Centre for Innovative Medicine, Department of Immunology, Vilnius, Lithuania
         type:PostalAddress
      name:Wroclaw Medical University
      address:
         name:Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
         type:PostalAddress
      name:State Research Institute Centre for Innovative Medicine, Department of Immunology
      address:
         name:State Research Institute Centre for Innovative Medicine, Department of Immunology, Vilnius, Lithuania
         type:PostalAddress
      name:Vilnius Gediminas Technical University
      address:
         name:Faculty of Electronics, Vilnius Gediminas Technical University, Vilnius, Lithuania
         type:PostalAddress
      name:Wroclaw Medical University
      address:
         name:Department of Drug Technology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Natalia Sauer
      affiliation:
            name:Wroclaw Medical University
            address:
               name:Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
               type:PostalAddress
            type:Organization
      name:Natalia Janicka
      affiliation:
            name:Wroclaw Medical University
            address:
               name:Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
               type:PostalAddress
            type:Organization
      name:Wojciech Szlasa
      affiliation:
            name:Wroclaw Medical University
            address:
               name:Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland
               type:PostalAddress
            type:Organization
      name:Bartłomiej Skinderowicz
      affiliation:
            name:Wroclaw University of Science and Technology
            address:
               name:Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland
               type:PostalAddress
            type:Organization
      name:Katarzyna Kołodzińska
      affiliation:
            name:Wroclaw University of Science and Technology
            address:
               name:Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland
               type:PostalAddress
            type:Organization
      name:Wioletta Dwernicka
      affiliation:
            name:Poznan University of Medical Sciences
            address:
               name:Faculty of Medicine, Poznan University of Medical Sciences, Poznan, Poland
               type:PostalAddress
            type:Organization
      name:Małgorzata Oślizło
      affiliation:
            name:Wroclaw Medical University
            address:
               name:Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland
               type:PostalAddress
            type:Organization
      name:Julita Kulbacka
      affiliation:
            name:State Research Institute Centre for Innovative Medicine, Department of Immunology
            address:
               name:State Research Institute Centre for Innovative Medicine, Department of Immunology, Vilnius, Lithuania
               type:PostalAddress
            type:Organization
            name:Wroclaw Medical University
            address:
               name:Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Vitalij Novickij
      affiliation:
            name:State Research Institute Centre for Innovative Medicine, Department of Immunology
            address:
               name:State Research Institute Centre for Innovative Medicine, Department of Immunology, Vilnius, Lithuania
               type:PostalAddress
            type:Organization
            name:Vilnius Gediminas Technical University
            address:
               name:Faculty of Electronics, Vilnius Gediminas Technical University, Vilnius, Lithuania
               type:PostalAddress
            type:Organization
      name:Katarzyna Karłowicz-Bodalska
      affiliation:
            name:Wroclaw Medical University
            address:
               name:Department of Drug Technology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
      name:Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
      name:Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland
      name:Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland
      name:Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland
      name:Faculty of Medicine, Poznan University of Medical Sciences, Poznan, Poland
      name:Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland
      name:State Research Institute Centre for Innovative Medicine, Department of Immunology, Vilnius, Lithuania
      name:Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland
      name:State Research Institute Centre for Innovative Medicine, Department of Immunology, Vilnius, Lithuania
      name:Faculty of Electronics, Vilnius Gediminas Technical University, Vilnius, Lithuania
      name:Department of Drug Technology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland

External Links {🔗}(574)

Analytics and Tracking {📊}

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Libraries {📚}

  • Clipboard.js
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CDN Services {📦}

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