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Title:
TIM-3 as a promising target for cancer immunotherapy in a wide range of tumors | Cancer Immunology, Immunotherapy
Description:
T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) expression has been a trending topic in recent years due to its differential expression in a wide range of neoplasms. TIM-3 is one of the key immune checkpoint receptors that interact with GAL-9, PtdSer, HMGB1 and CEACAM1. Initially identified on the surface of T helper 1 (Th1) lymphocytes and later on cytotoxic lymphocytes (CTLs), monocytes, macrophages, natural killer cells (NKs), and dendritic cells (DCs), TIM-3 plays a key role in immunoregulation. Recently, a growing body of evidence has shown that its differential expression in various tumor types indicates a specific prognosis for cancer patients. Here, we discuss which types of cancer TIM-3 can serve as a prognostic factor and the influence of coexpressed immune checkpoint inhibitors, such as LAG-3, PD-1, and CTLA-4 on patients
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Keywords {🔍}
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Topics {✒️}
5700616/attachment/fe29be34-b63b-4d1b-a7c2-e1ff6979d27b/mmc1 lymphomas—full text view—clinicaltrials neck—full text view—clinicaltrials anti-tim-3/anti-pd-l1 bispecific antibody tumor-induced ny-eso-1-specific cd8 + full text view—clinicaltrials tumor-infiltrating b-cell supernatant tim-3 + pd-1 + ny-eso-1-specific cd8 + anti-tim-3 targeted therapies lps/tlr4-induced pro-inflammatory response cd8 + t-cell functions improved anti-pd-l1 triggered overexpression /glial-tim-3-modulates-immune-responses myeloid-derived suppressor cells anaplastic-thyroid-cancer-infiltrating macrophages /phase-i-ib-clinical-trial sequentially tumor-selected antibody anti-tim-3/anti-pd-1 antibodies cell-based therapies anti-inflammatory/pro-tumorigenic phenotype potentiates fcεri-proximal signaling article download pdf attenuate gal-9/tim-3-induced apoptosis anti-pd-1/anti-tim-3 blockade mitogen-activated protein kinase t-bet mrna expression glioma cell-intrinsic tim-3 pd-1/pd-l1 blockade upregulate t-cell immunoglobulin domain t-cell-deficient mice nf-κb/il-6/stat3 axis t-cell ratio predicts restore anti-tumor immunity marked t-cell activation anti-tim-3 bispecific focus highly dysfunctional tumor-induced suppresses cell-mediated cytotoxicity transcription factor t-bet anti-tim-3 monoclonal antibodies monoclonal anti-tim-3 antibodies restored anti-tumor immunity triple-negative breast cancer insights fromsingle-cell analysis galectin-9-induced cell death ccl4-induced mouse model cd8 + t-cell dysfunction fyn-jak1-znf384 pathways anti-tim3 antibody promotes anti-cancer therapeutic strategies enhancing anti-tumor activity
Questions {❓}
- Ganjalikhani Hakemi M, Jafarinia M, Azizi M, Rezaeepoor M, Isayev O, Bazhin AV (2020) The role of TIM-3 in hepatocellular carcinoma: a promising target for immunotherapy?
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headline:TIM-3 as a promising target for cancer immunotherapy in a wide range of tumors
description:T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) expression has been a trending topic in recent years due to its differential expression in a wide range of neoplasms. TIM-3 is one of the key immune checkpoint receptors that interact with GAL-9, PtdSer, HMGB1 and CEACAM1. Initially identified on the surface of T helper 1 (Th1) lymphocytes and later on cytotoxic lymphocytes (CTLs), monocytes, macrophages, natural killer cells (NKs), and dendritic cells (DCs), TIM-3 plays a key role in immunoregulation. Recently, a growing body of evidence has shown that its differential expression in various tumor types indicates a specific prognosis for cancer patients. Here, we discuss which types of cancer TIM-3 can serve as a prognostic factor and the influence of coexpressed immune checkpoint inhibitors, such as LAG-3, PD-1, and CTLA-4 on patients' outcomes. Currently, experimental medicine involving TIM-3 has significantly enhanced the anti-tumor effect and improved patient survival. In this work, we summarized clinical trials incorporating TIM-3 targeting monoclonal and bispecific antibodies in monotherapy and combination therapy and highlighted the emerging role of cell-based therapies.
datePublished:2023-08-11T00:00:00Z
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Cancer
Immunotherapy
TIM-3
T-cells
Oncology
Immunology
Cancer Research
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headline:TIM-3 as a promising target for cancer immunotherapy in a wide range of tumors
description:T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) expression has been a trending topic in recent years due to its differential expression in a wide range of neoplasms. TIM-3 is one of the key immune checkpoint receptors that interact with GAL-9, PtdSer, HMGB1 and CEACAM1. Initially identified on the surface of T helper 1 (Th1) lymphocytes and later on cytotoxic lymphocytes (CTLs), monocytes, macrophages, natural killer cells (NKs), and dendritic cells (DCs), TIM-3 plays a key role in immunoregulation. Recently, a growing body of evidence has shown that its differential expression in various tumor types indicates a specific prognosis for cancer patients. Here, we discuss which types of cancer TIM-3 can serve as a prognostic factor and the influence of coexpressed immune checkpoint inhibitors, such as LAG-3, PD-1, and CTLA-4 on patients' outcomes. Currently, experimental medicine involving TIM-3 has significantly enhanced the anti-tumor effect and improved patient survival. In this work, we summarized clinical trials incorporating TIM-3 targeting monoclonal and bispecific antibodies in monotherapy and combination therapy and highlighted the emerging role of cell-based therapies.
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Immunotherapy
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T-cells
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Cancer Research
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