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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
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We are analyzing https://link.springer.com/article/10.1007/s00262-019-02423-8.

Title:
Predominance of M2 macrophages in gliomas leads to the suppression of local and systemic immunity | Cancer Immunology, Immunotherapy
Description:
Glioblastoma is a highly prevalent and aggressive form of primary brain tumor. It represents approximately 56% of all the newly diagnosed gliomas. Macrophages are one of the major constituents of tumor-infiltrating immune cells in the human gliomas. The role of immunosuppressive macrophages is very well documented in correlation with the poor prognosis of patients suffering from breast, prostate, bladder and cervical cancers. The current study highlights the correlation between the tumor-associated macrophage phenotypes and glioma progression. We observed an increase in the pool of M2 macrophages in high-grade gliomas, as confirmed by their CD68 and CD163 double-positive phenotype. In contrast, less M1 macrophages were noticed in high-grade gliomas, as evidenced by the down-regulation in the expression of CCL3 marker. In addition, we observed that higher gene expression ratio of CD163/CCL3 is associated with glioma progression. The Kaplan–Meier survival plots indicate that glioma patients with lower expression of M2c marker (CD163), and higher expression of M1 marker (CCL3) had better survival. Furthermore, we examined the systemic immune response in the peripheral blood and noted a predominance of M2 macrophages, myeloid-derived suppressor cells and PD-1+ CD4 T cells in glioma patients. Thus, the study indicates a high gene expression ratio of CD163/CCL3 in high-grade gliomas as compared to low-grade gliomas and significantly elevated frequency of M2 macrophages and PD-1+ CD4 T cells in the blood of tumor patients. These parameters could be used as an indicator of the early diagnosis and prognosis of the disease.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

pubmed, article, google, scholar, cas, macrophages, central, cancer, cells, research, glioblastoma, human, glioma, expression, gliomas, vidyarthi, khan, immune, india, agnihotri, brain, macrophage, access, cell, content, agrewala, tumor, immunol, department, institute, chandigarh, privacy, cookies, patients, tumorassociated, progression, front, medical, institutional, data, information, publish, search, systemic, aurobind, tapan, nargis, javed, study, highgrade,

Topics {✒️}

anti-csf-1r antibody reveals cd14 + hla-drlo/neg monocytes month download article/chapter cd163 double-positive phenotype human monocytic/microglial activation tumor-infiltrating immune cells myeloid-derived suppressor cells systemic immune response article cancer immunology kaplan–meier survival plots tumour-derived lactic acid hernandez-martinez jm related subjects immune checkpoint modulators cancer drug resistance full article pdf t-cell exhaustion machine learning peripheral t-cells privacy choices/manage cookies maldonado-leal fm cell priming capability human brain tumors systemic immune suppression promising therapeutic target ifn-alphabeta signaling current therapeutic alternatives article vidyarthi allogeneic dendritic cells high-grade gliomas tumor-induced immunosuppression low-grade gliomas pd-1/pd-l1 primary brain tumor european economic area significantly elevated frequency human monocytes stat6-dependent expression reis-filho js van eden cg refractory solid tumors �institutional biosafety committee article log cancer cell 25 mapping glioma progression blocks glioma progression dc analyzed data check access instant access conditions privacy policy

Questions {❓}

  • Fahrenhold M, Rakic S, Classey J, Brayne C, Ince PG, Nicoll JAR, Boche D, Mrc C (2018) TREM2 expression in the human brain: a marker of monocyte recruitment?

Schema {🗺️}

WebPage:
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         description:Glioblastoma is a highly prevalent and aggressive form of primary brain tumor. It represents approximately 56% of all the newly diagnosed gliomas. Macrophages are one of the major constituents of tumor-infiltrating immune cells in the human gliomas. The role of immunosuppressive macrophages is very well documented in correlation with the poor prognosis of patients suffering from breast, prostate, bladder and cervical cancers. The current study highlights the correlation between the tumor-associated macrophage phenotypes and glioma progression. We observed an increase in the pool of M2 macrophages in high-grade gliomas, as confirmed by their CD68 and CD163 double-positive phenotype. In contrast, less M1 macrophages were noticed in high-grade gliomas, as evidenced by the down-regulation in the expression of CCL3 marker. In addition, we observed that higher gene expression ratio of CD163/CCL3 is associated with glioma progression. The Kaplan–Meier survival plots indicate that glioma patients with lower expression of M2c marker (CD163), and higher expression of M1 marker (CCL3) had better survival. Furthermore, we examined the systemic immune response in the peripheral blood and noted a predominance of M2 macrophages, myeloid-derived suppressor cells and PD-1+ CD4 T cells in glioma patients. Thus, the study indicates a high gene expression ratio of CD163/CCL3 in high-grade gliomas as compared to low-grade gliomas and significantly elevated frequency of M2 macrophages and PD-1+ CD4 T cells in the blood of tumor patients. These parameters could be used as an indicator of the early diagnosis and prognosis of the disease.
         datePublished:2019-11-05T00:00:00Z
         dateModified:2019-11-05T00:00:00Z
         pageStart:1995
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            Immunology
            Cancer Research
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      headline:Predominance of M2 macrophages in gliomas leads to the suppression of local and systemic immunity
      description:Glioblastoma is a highly prevalent and aggressive form of primary brain tumor. It represents approximately 56% of all the newly diagnosed gliomas. Macrophages are one of the major constituents of tumor-infiltrating immune cells in the human gliomas. The role of immunosuppressive macrophages is very well documented in correlation with the poor prognosis of patients suffering from breast, prostate, bladder and cervical cancers. The current study highlights the correlation between the tumor-associated macrophage phenotypes and glioma progression. We observed an increase in the pool of M2 macrophages in high-grade gliomas, as confirmed by their CD68 and CD163 double-positive phenotype. In contrast, less M1 macrophages were noticed in high-grade gliomas, as evidenced by the down-regulation in the expression of CCL3 marker. In addition, we observed that higher gene expression ratio of CD163/CCL3 is associated with glioma progression. The Kaplan–Meier survival plots indicate that glioma patients with lower expression of M2c marker (CD163), and higher expression of M1 marker (CCL3) had better survival. Furthermore, we examined the systemic immune response in the peripheral blood and noted a predominance of M2 macrophages, myeloid-derived suppressor cells and PD-1+ CD4 T cells in glioma patients. Thus, the study indicates a high gene expression ratio of CD163/CCL3 in high-grade gliomas as compared to low-grade gliomas and significantly elevated frequency of M2 macrophages and PD-1+ CD4 T cells in the blood of tumor patients. These parameters could be used as an indicator of the early diagnosis and prognosis of the disease.
      datePublished:2019-11-05T00:00:00Z
      dateModified:2019-11-05T00:00:00Z
      pageStart:1995
      pageEnd:2004
      sameAs:https://doi.org/10.1007/s00262-019-02423-8
      keywords:
         Glioma
         Tumor-associated macrophages
         CD163
         CCL3
         PD-1
         Oncology
         Immunology
         Cancer Research
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                  address:
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                     type:PostalAddress
                  type:Organization
                  name:Yale University School of Medicine
                  address:
                     name:Department of Rheumatology, Yale University School of Medicine, New Haven, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tapan Agnihotri
            affiliation:
                  name:CSIR-Institute of Microbial Technology
                  address:
                     name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
                     type:PostalAddress
                  type:Organization
                  name:McGill University
                  address:
                     name:Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
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                  address:
                     name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
                     type:PostalAddress
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                  name:McGill University
                  address:
                     name:Meakins-Christie Laboratories, McGill University, Montreal, Canada
                     type:PostalAddress
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            type:Person
            name:Sanpreet Singh
            affiliation:
                  name:CSIR-Institute of Microbial Technology
                  address:
                     name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
                     type:PostalAddress
                  type:Organization
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            name:Manoj K. Tewari
            affiliation:
                  name:Postgraduate Institute of Medical Education and Research
                  address:
                     name:Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bishan D. Radotra
            affiliation:
                  name:Postgraduate Institute of Medical Education and Research
                  address:
                     name:Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
                     type:PostalAddress
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            name:Deepyan Chatterjee
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                  address:
                     name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
                     type:PostalAddress
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                  address:
                     name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
                     type:PostalAddress
                  type:Organization
                  name:Indian Institute of Technology
                  address:
                     name:Indian Institute of Technology, Ropar, India
                     type:PostalAddress
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      name:Cancer Immunology, Immunotherapy
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      volumeNumber:68
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      name:CSIR-Institute of Microbial Technology
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         name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
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      address:
         name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
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         name:Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
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      address:
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      name:McGill University
      address:
         name:Meakins-Christie Laboratories, McGill University, Montreal, Canada
         type:PostalAddress
      name:CSIR-Institute of Microbial Technology
      address:
         name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
         type:PostalAddress
      name:Postgraduate Institute of Medical Education and Research
      address:
         name:Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India
         type:PostalAddress
      name:Postgraduate Institute of Medical Education and Research
      address:
         name:Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
         type:PostalAddress
      name:CSIR-Institute of Microbial Technology
      address:
         name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
         type:PostalAddress
      name:CSIR-Institute of Microbial Technology
      address:
         name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
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      affiliation:
            name:CSIR-Institute of Microbial Technology
            address:
               name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
               type:PostalAddress
            type:Organization
            name:Yale University School of Medicine
            address:
               name:Department of Rheumatology, Yale University School of Medicine, New Haven, USA
               type:PostalAddress
            type:Organization
      name:Tapan Agnihotri
      affiliation:
            name:CSIR-Institute of Microbial Technology
            address:
               name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
               type:PostalAddress
            type:Organization
            name:McGill University
            address:
               name:Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
               type:PostalAddress
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      name:Nargis Khan
      affiliation:
            name:CSIR-Institute of Microbial Technology
            address:
               name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
               type:PostalAddress
            type:Organization
            name:McGill University
            address:
               name:Meakins-Christie Laboratories, McGill University, Montreal, Canada
               type:PostalAddress
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      affiliation:
            name:CSIR-Institute of Microbial Technology
            address:
               name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
               type:PostalAddress
            type:Organization
      name:Manoj K. Tewari
      affiliation:
            name:Postgraduate Institute of Medical Education and Research
            address:
               name:Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India
               type:PostalAddress
            type:Organization
      name:Bishan D. Radotra
      affiliation:
            name:Postgraduate Institute of Medical Education and Research
            address:
               name:Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
               type:PostalAddress
            type:Organization
      name:Deepyan Chatterjee
      affiliation:
            name:CSIR-Institute of Microbial Technology
            address:
               name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
               type:PostalAddress
            type:Organization
      name:Javed N. Agrewala
      affiliation:
            name:CSIR-Institute of Microbial Technology
            address:
               name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
               type:PostalAddress
            type:Organization
            name:Indian Institute of Technology
            address:
               name:Indian Institute of Technology, Ropar, India
               type:PostalAddress
            type:Organization
      email:[email protected]
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      name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
      name:Department of Rheumatology, Yale University School of Medicine, New Haven, USA
      name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
      name:Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
      name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
      name:Meakins-Christie Laboratories, McGill University, Montreal, Canada
      name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
      name:Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India
      name:Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
      name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
      name:Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India
      name:Indian Institute of Technology, Ropar, India
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External Links {🔗}(178)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

4.39s.