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We are analyzing https://link.springer.com/article/10.1007/s00262-013-1475-x.

Title:
Myeloid-derived suppressor cells are associated with disease progression and decreased overall survival in advanced-stage melanoma patients | Cancer Immunology, Immunotherapy
Description:
Myeloid-derived suppressor cells are increased in the peripheral blood of advanced-stage cancer patients; however, no studies have shown a correlation of these immunosuppressive cells with clinical outcomes in melanoma patients. We characterized the frequency and suppressive function of multiple subsets of myeloid-derived suppressor cells in the peripheral blood of 34 patients with Stage IV melanoma, 20 patients with Stage I melanoma, and 15 healthy donors. The frequency of CD14+ MDSCs (Linโˆ’ CD11b+ HLA-DRโˆ’ CD14+ CD33+) and CD14โˆ’ MDSCs (Linโˆ’ CD11b+ HLA-DRโˆ’ CD14โˆ’ CD33+) was increased in the peripheral blood of Stage IV melanoma patients relative to healthy donors. The frequency of CD14+ and CD14โˆ’ MDSCs correlated with each other and with the increased frequency of regulatory T cells, but not with classically defined monocytes. CD14โˆ’ MDSCs isolated from the peripheral blood of Stage IV melanoma patients suppressed T cell activation more than those isolated from healthy donors, and the frequency of these cells correlated with disease progression and decreased overall survival. Our study provides the first evidence that the frequency of CD14โˆ’ MDSCs negatively correlates with clinical outcomes in advanced-stage melanoma patients. These data indicate that suppressive MDSCs should be considered as targets for future immunotherapies.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {๐Ÿ“š}

  • Science
  • Health & Fitness
  • Education

Content Management System {๐Ÿ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {๐Ÿ“ˆ}

What is the average monthly size of link.springer.com audience?

๐ŸŒ  Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {๐Ÿ’ธ}

We donโ€™t know how the website earns money.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {๐Ÿ”}

article, cancer, google, scholar, cells, pubmed, cas, suppressor, patients, myeloidderived, melanoma, immunol, res, cell, blood, tumor, myeloid, stage, clin, immunother, increased, mdscs, metastatic, immune, frequency, tcell, gabrilovich, privacy, cookies, content, data, progression, survival, advancedstage, peripheral, clinical, subsets, access, med, activity, usa, human, university, colorado, function, publish, research, search, immunotherapy, mccarter,

Topics {โœ’๏ธ}

granulocyte-macrophage colony-stimulating factor cd14+ย hla-drโˆ’/low mdscs tumor-specific t-cell memory myeloid-derived suppressor cells month download article/chapter suppress t-cell proliferation myeloid cell-mediated immunosuppression human dendritic cells t-cell transfer immunotherapy anti-pd-l1 antibody myeloid suppressor cells immature myeloid cells related subjects cd15+/cd16low human granulocytes regulatory t-cell hurdle advanced-stage cancer patients advanced-stage melanoma patients hif-1alpha regulates function myeloid cells obtained article cancer immunology diaz-montero cm reduced interferon-alpha signaling cell tolerance induced anti-pd-1 antibody stage iv melanoma inhibiting antitumor immunity full article pdf renal cell carcinoma independent prognostic factor t-cell subsets kirkwood jm t-cell immunity privacy choices/manage cookies clinical cancer stage th2 cytokine interleukin-13 classically defined monocytes immune suppression mediated myeloid cells cell-suppressive activity durable complete responses immunosuppressive cells lymphopenia improves adoptive sarnaik aa cd14โˆ’ mdscs correlated metastatic tumor burden tumor-bearing mice terminal cancer patients cd14โˆ’ mdscs isolated limits tumor progression european economic area

Schema {๐Ÿ—บ๏ธ}

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         headline:Myeloid-derived suppressor cells are associated with disease progression and decreased overall survival in advanced-stage melanoma patients
         description:Myeloid-derived suppressor cells are increased in the peripheral blood of advanced-stage cancer patients; however, no studies have shown a correlation of these immunosuppressive cells with clinical outcomes in melanoma patients. We characterized the frequency and suppressive function of multiple subsets of myeloid-derived suppressor cells in the peripheral blood of 34 patients with Stage IV melanoma, 20 patients with Stage I melanoma, and 15 healthy donors. The frequency of CD14+ MDSCs (Linโˆ’ CD11b+ HLA-DRโˆ’ CD14+ CD33+) and CD14โˆ’ MDSCs (Linโˆ’ CD11b+ HLA-DRโˆ’ CD14โˆ’ CD33+) was increased in the peripheral blood of Stage IV melanoma patients relative to healthy donors. The frequency of CD14+ and CD14โˆ’ MDSCs correlated with each other and with the increased frequency of regulatory T cells, but not with classically defined monocytes. CD14โˆ’ MDSCs isolated from the peripheral blood of Stage IV melanoma patients suppressed T cell activation more than those isolated from healthy donors, and the frequency of these cells correlated with disease progression and decreased overall survival. Our study provides the first evidence that the frequency of CD14โˆ’ MDSCs negatively correlates with clinical outcomes in advanced-stage melanoma patients. These data indicate that suppressive MDSCs should be considered as targets for future immunotherapies.
         datePublished:2013-09-27T00:00:00Z
         dateModified:2013-09-27T00:00:00Z
         pageStart:1711
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            Immunotherapy
            Immunosuppression
            Melanoma
            Oncology
            Immunology
            Cancer Research
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      headline:Myeloid-derived suppressor cells are associated with disease progression and decreased overall survival in advanced-stage melanoma patients
      description:Myeloid-derived suppressor cells are increased in the peripheral blood of advanced-stage cancer patients; however, no studies have shown a correlation of these immunosuppressive cells with clinical outcomes in melanoma patients. We characterized the frequency and suppressive function of multiple subsets of myeloid-derived suppressor cells in the peripheral blood of 34 patients with Stage IV melanoma, 20 patients with Stage I melanoma, and 15 healthy donors. The frequency of CD14+ MDSCs (Linโˆ’ CD11b+ HLA-DRโˆ’ CD14+ CD33+) and CD14โˆ’ MDSCs (Linโˆ’ CD11b+ HLA-DRโˆ’ CD14โˆ’ CD33+) was increased in the peripheral blood of Stage IV melanoma patients relative to healthy donors. The frequency of CD14+ and CD14โˆ’ MDSCs correlated with each other and with the increased frequency of regulatory T cells, but not with classically defined monocytes. CD14โˆ’ MDSCs isolated from the peripheral blood of Stage IV melanoma patients suppressed T cell activation more than those isolated from healthy donors, and the frequency of these cells correlated with disease progression and decreased overall survival. Our study provides the first evidence that the frequency of CD14โˆ’ MDSCs negatively correlates with clinical outcomes in advanced-stage melanoma patients. These data indicate that suppressive MDSCs should be considered as targets for future immunotherapies.
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         Immunotherapy
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         Melanoma
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         Cancer Research
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