We are analyzing https://link.springer.com/article/10.1007/s00262-011-1184-2.

Title:
Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin | Cancer Immunology, Immunotherapy
Description:
Surface-exposed HSP70 and calreticulin are damage-associated molecular patterns (DAMPs) crucially involved in modulating the success of cancer therapy. Photodynamic therapy (PDT) involves the administration of a photosensitising (PTS) agent followed by visible light-irradiation. The reactive oxygen species that are thus generated directly kill tumours by damaging their microvasculature and inducing a local inflammatory reaction. PDT with the PTS photofrin is associated with DAMPs exposure, but the same is not true for other PTSs. Here, we show that when cancer cells are treated with hypericin-based PDT (Hyp-PDT), they surface-expose both HSP70 and calreticulin (CRT). Induction of CRT exposure was not accompanied by co-exposure of ERp57, but this did not compromise the ability of the exposed CRT to regulate the phagocytosis of Hyp-PDT-treated cancer cells by dendritic cells. Interestingly, we found that Hyp-PDT-induced CRT exposure (in contrast to anthracycline-induced CRT exposure) was independent of the presence of ERp57. Our results indicate that Hyp-PDT is a potential anti-cancer immunogenic modality.
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Keywords {🔍}

article, pubmed, google, scholar, cas, cancer, cell, photodynamic, therapy, research, death, cells, calreticulin, agostinis, molecular, krysko, vandenabeele, exposure, hsp, garg, damps, surface, damageassociated, patterns, author, immunol, privacy, cookies, peter, crt, erp, korbelik, content, publish, search, hypericinbased, dmitri, pdt, access, van, zitvogel, kroemer, immunity, tumor, belgium, fwovlaanderen, ghent, data, policy, information,

Topics {✒️}

complement-independent antibody-mediated phagocytosis pdt-mediated photo-oxidative stress month download article/chapter hypericin-mediated photodynamic therapy hyp-pdt-induced crt exposure photodynamic therapy-generated vaccines photodynamic therapy-generated vaccine hyp-pdt-treated cancer cells anthracycline-induced crt exposure hypericin-based pdt pre-apoptotic calreticulin exposure endoplasmic reticulum depletion tumor-specific immune response article cancer immunology hypericin-induced photosensitization heat shock proteins krysko & peter vandenabeele photodynamic therapy treatment full article pdf privacy choices/manage cookies calreticulin exposure dictates federal research program hsp70 translocation induced vesalius research center garg ad european economic area article garg scientific research flanders immunogenic cell death cancer cell death molecular biomedical research author information authors anti-tumour immunity surface expression visible light-irradiation reactive oxygen species local inflammatory reaction murphy-ullrich je multidomain proapoptotic bax ugent mrp initiative fp7 apo-sys 200767 shaping cell death tumor cell death conditions privacy policy group-id consortium biomedical molecular biology cancer immunol immunother photodynamic therapy hela cells leads ko mef cells

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         description:Surface-exposed HSP70 and calreticulin are damage-associated molecular patterns (DAMPs) crucially involved in modulating the success of cancer therapy. Photodynamic therapy (PDT) involves the administration of a photosensitising (PTS) agent followed by visible light-irradiation. The reactive oxygen species that are thus generated directly kill tumours by damaging their microvasculature and inducing a local inflammatory reaction. PDT with the PTS photofrin is associated with DAMPs exposure, but the same is not true for other PTSs. Here, we show that when cancer cells are treated with hypericin-based PDT (Hyp-PDT), they surface-expose both HSP70 and calreticulin (CRT). Induction of CRT exposure was not accompanied by co-exposure of ERp57, but this did not compromise the ability of the exposed CRT to regulate the phagocytosis of Hyp-PDT-treated cancer cells by dendritic cells. Interestingly, we found that Hyp-PDT-induced CRT exposure (in contrast to anthracycline-induced CRT exposure) was independent of the presence of ERp57. Our results indicate that Hyp-PDT is a potential anti-cancer immunogenic modality.
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      headline:Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin
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