We are analyzing https://link.springer.com/article/10.1007/s00262-008-0653-8.

Title:
Ipilimumab: controversies in its development, utility and autoimmune adverse events | Cancer Immunology, Immunotherapy
Description:
A promising new class of anti-cancer drugs includes antibodies that mediate immune regulatory effects. It has become very clear over the last decade that different types of immune cells and different pathways serve to suppress anti-cancer immunity, particularly in the microenvironment of the tumor. The first examples of immune modulating antibodies are those directed against cytotoxic T lymphocyte antigen-4 (CTLA-4), a molecule present on activated T cells. Human antibodies that abrogate the function of CTLA-4 have been tested in the clinic and found to have clinical activity against melanoma. In this review, we discuss some of the controversies surrounding the potential clinical utility of one of those antibodies, ipilimumab, formerly MDX-010, from Medarex and Bristol Myers Squibb. The optimal dose and schedule of ipilimumab was derived in multiple clinical trials whose latest results are described below. Favorable survival in patients with stage IV melanoma were observed that appear to be associated with unique side effects of the drug called “immune-related adverse events”. The management of these side effects is described, and the unusual kinetics of anti-tumor response with ipilimumab as well as a newly proposed schema for assessing anti-tumor responses in patients receiving biologic compounds like ipilimumab, which may supercede RECIST or WHO criteria, are addressed.
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Keywords {🔍}

article, melanoma, google, scholar, pubmed, patients, ipilimumab, cas, clin, cancer, oncol, ctla, weber, suppl, antibody, blockade, antigen, metastatic, abstr, research, immunotherapy, cytotoxic, response, advanced, cells, clinical, mdx, antitumor, usa, privacy, cookies, content, antibodies, effects, responses, antictla, allison, treated, efficacy, phase, information, publish, search, adverse, events, review, regulatory, immunity, dose, survival,

Topics {✒️}

month download article/chapter anti-ctla-4 monoclonal antibody anti-cytotoxic t-lymphocyte antigen-4 immune-related adverse events article cancer immunology anti-ctla-4 antibody ipilimumab autoimmune adverse events suppress anti-cancer immunity assessing anti-tumor responses anti-ctla-4 antibody stage iii/iv melanoma full article pdf sixth annual meeting long-term survival privacy choices/manage cookies receives research funding maker av cytotoxic t-lymphocyte induce autoimmune hypophysitis prognostic factors related immune modulating antibodies unresectable stage iii article weber prior therapies resected stages iii regulatory t-cells blansfield ja intrapatient dose escalation ctla-4-deficient mice t-cell responses stage iv melanoma european economic area bristol myers squibb newly proposed schema krummel mf phan gq resected stages iiic costimulation-dependent activation bristol-myers squibb dose-ranging study anti-tumor response human antibodies conditions privacy policy multiple melanoma peptides jeffrey weber multiple clinical trials antibody blockade received ipilimumab administered previously treated patients related subjects

Questions {❓}

Ménard C, Ghiringhelli F, Roux S et al (2008) CTLA-4 blockade confers lymphocyte resistance to regulatory T-cells in advanced melanoma: surrogate marker of efficacy of tremelimumab?

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