We are analyzing https://link.springer.com/article/10.1007/s00262-008-0515-4.

Title:
Molecular mechanisms of MHC class I abnormalities and APM components in human tumors | Cancer Immunology, Immunotherapy
Description:
Tumor immune escape plays a critical role in cancer, but the mechanisms involved in this process have still to be defined. In the recent years, progress has been made in understanding how peptides presented by MHC class I molecules were generated, in particular which proteases are involved in this process and how intracellular pathways influence antigen presentation in professional antigen-presenting cells and in various types of malignancies. Different MHC class I abnormalities have been found in solid tumors of distinct origin, but also in hematopoietic diseases. These include structural alterations such as total, haplotype and allelic loss of the MHC class I heavy chain, deletions and point mutations, in particular in β2-microglobulin and TAP1 as well as dysregulation of various components of the MHC class I antigen processing machinery (APM), which could occur at the epigenetic, transcriptional and posttranscriptional level. The lack or downmodulation of the expression of single or multiple components of the MHC class I antigen processing pathway may avoid the recognition of tumor cells by tumor-specific CD8+ cytotoxic T lymphocytes. This review will give an overview of the underlying molecular mechanisms of MHC class I abnormalities in human tumors of distinct histology, which also might have an impact on the design of T cell-based immunotherapies.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Fitness & Wellness
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

google, scholar, pubmed, cas, article, class, cancer, antigen, mhc, immunol, human, cell, processing, expression, hla, seliger, loss, cells, tap, aminopeptidase, carcinoma, complex, res, tumors, machinery, peptide, garrido, ferrone, melanoma, presentation, major, histocompatibility, renal, int, mechanisms, components, molecular, immune, molecules, cabrera, ruizcabello, immunother, nat, tumor, immunity, downregulation, privacy, cookies, content, immunology,

Topics {✒️}

epstein-barr virus-encoded interleukin–10 month download article/chapter beta2-microglobulin gene mutation ifn-gamma-mediated activation hla-b27 messenger rnas high-frequency microsatellite instability professional antigen-presenting cells tumor-specific cd8+ cytotoxic human mhc-linked transporters cell cycle-dependent expression article cancer immunology full article pdf van endert pm immune escape phenotype major histocompatibility class antigen-processing machinery components immune escape mechanism cancer/testis antigens expression privacy choices/manage cookies tumor immune evasion renal cell carcinoma malignant renal cells /beta2-microglobulin complex camp-increasing mediators peptide loading complex peptide-loading complex immune selective pressure renal carcinoma cells high nk sensitivity cell-based immunotherapy functionally defective allele microdissected tumor cells dendritic cell maturation antigen processing machinery antigen-processing machinery human hepatocellular carcinoma human gastric carcinoma lópez nevot ma β2-microglobulin loh antigen processing occurs koebel cm neutral peptidase activity cell-based immunotherapies human lung cancer melanoma cell lines human gastric cancers human cervical carcinoma article seliger lopez nevot ma lopez-nevot ma

Questions {❓}

Atkins D, Ferrone S, Schmahl GE, Storkel S, Seliger B (2004) Down-regulation of HLA class I antigen processing molecules: an immune escape mechanism of renal cell carcinoma?
Ramnath N, Tan D, Li Q, Hylander BL, Bogner P, Ryes L, Ferrone S (2006) Is downregulation of MHC class I antigen expression in human non-small cell lung cancer associated with prolonged survival?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Molecular mechanisms of MHC class I abnormalities and APM components in human tumors
         description:Tumor immune escape plays a critical role in cancer, but the mechanisms involved in this process have still to be defined. In the recent years, progress has been made in understanding how peptides presented by MHC class I molecules were generated, in particular which proteases are involved in this process and how intracellular pathways influence antigen presentation in professional antigen-presenting cells and in various types of malignancies. Different MHC class I abnormalities have been found in solid tumors of distinct origin, but also in hematopoietic diseases. These include structural alterations such as total, haplotype and allelic loss of the MHC class I heavy chain, deletions and point mutations, in particular in β2-microglobulin and TAP1 as well as dysregulation of various components of the MHC class I antigen processing machinery (APM), which could occur at the epigenetic, transcriptional and posttranscriptional level. The lack or downmodulation of the expression of single or multiple components of the MHC class I antigen processing pathway may avoid the recognition of tumor cells by tumor-specific CD8+ cytotoxic T lymphocytes. This review will give an overview of the underlying molecular mechanisms of MHC class I abnormalities in human tumors of distinct histology, which also might have an impact on the design of T cell-based immunotherapies.
         datePublished:2008-04-12T00:00:00Z
         dateModified:2008-04-12T00:00:00Z
         pageStart:1719
         pageEnd:1726
         sameAs:https://doi.org/10.1007/s00262-008-0515-4
         keywords:
            Antigen processing
            Gene regulation
            Immune escape
            MHC class I
            Tumors
            Oncology
            Immunology
            Cancer Research
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-008-0515-4/MediaObjects/262_2008_515_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-008-0515-4/MediaObjects/262_2008_515_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-008-0515-4/MediaObjects/262_2008_515_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-008-0515-4/MediaObjects/262_2008_515_Fig4_HTML.gif
         isPartOf:
            name:Cancer Immunology, Immunotherapy
            issn:
               1432-0851
               0340-7004
            volumeNumber:57
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Barbara Seliger
               affiliation:
                     name:Martin-Luther-Universität Halle-Wittenberg, Institute of Medical Immunology
                     address:
                        name:Martin-Luther-Universität Halle-Wittenberg, Institute of Medical Immunology, Halle (Saale), Germany
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Molecular mechanisms of MHC class I abnormalities and APM components in human tumors
      description:Tumor immune escape plays a critical role in cancer, but the mechanisms involved in this process have still to be defined. In the recent years, progress has been made in understanding how peptides presented by MHC class I molecules were generated, in particular which proteases are involved in this process and how intracellular pathways influence antigen presentation in professional antigen-presenting cells and in various types of malignancies. Different MHC class I abnormalities have been found in solid tumors of distinct origin, but also in hematopoietic diseases. These include structural alterations such as total, haplotype and allelic loss of the MHC class I heavy chain, deletions and point mutations, in particular in β2-microglobulin and TAP1 as well as dysregulation of various components of the MHC class I antigen processing machinery (APM), which could occur at the epigenetic, transcriptional and posttranscriptional level. The lack or downmodulation of the expression of single or multiple components of the MHC class I antigen processing pathway may avoid the recognition of tumor cells by tumor-specific CD8+ cytotoxic T lymphocytes. This review will give an overview of the underlying molecular mechanisms of MHC class I abnormalities in human tumors of distinct histology, which also might have an impact on the design of T cell-based immunotherapies.
      datePublished:2008-04-12T00:00:00Z
      dateModified:2008-04-12T00:00:00Z
      pageStart:1719
      pageEnd:1726
      sameAs:https://doi.org/10.1007/s00262-008-0515-4
      keywords:
         Antigen processing
         Gene regulation
         Immune escape
         MHC class I
         Tumors
         Oncology
         Immunology
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-008-0515-4/MediaObjects/262_2008_515_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-008-0515-4/MediaObjects/262_2008_515_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-008-0515-4/MediaObjects/262_2008_515_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-008-0515-4/MediaObjects/262_2008_515_Fig4_HTML.gif
      isPartOf:
         name:Cancer Immunology, Immunotherapy
         issn:
            1432-0851
            0340-7004
         volumeNumber:57
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Barbara Seliger
            affiliation:
                  name:Martin-Luther-Universität Halle-Wittenberg, Institute of Medical Immunology
                  address:
                     name:Martin-Luther-Universität Halle-Wittenberg, Institute of Medical Immunology, Halle (Saale), Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cancer Immunology, Immunotherapy
      issn:
         1432-0851
         0340-7004
      volumeNumber:57
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Martin-Luther-Universität Halle-Wittenberg, Institute of Medical Immunology
      address:
         name:Martin-Luther-Universität Halle-Wittenberg, Institute of Medical Immunology, Halle (Saale), Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Barbara Seliger
      affiliation:
            name:Martin-Luther-Universität Halle-Wittenberg, Institute of Medical Immunology
            address:
               name:Martin-Luther-Universität Halle-Wittenberg, Institute of Medical Immunology, Halle (Saale), Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Martin-Luther-Universität Halle-Wittenberg, Institute of Medical Immunology, Halle (Saale), Germany
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(203)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.13s.

LINK . SPRINGER . COM {}