We are analyzing https://link.springer.com/article/10.1007/s00262-006-0194-y.

Title:
CD4 regulatory T cells in human cancer pathogenesis | Cancer Immunology, Immunotherapy
Description:
Over the past decade, there has been an accelerated understanding of immune regulatory mechanisms. Peripheral immune regulation is linked to a collection of specialized regulatory cells of the CD4+ T cell lineage (i.e., CD4+ Tregs). This collection consists of Tregs that are either thymically derived (i.e., natural) or peripherally induced. Tregs are important for controlling potentially autoreactive immune effectors and immunity to foreign organisms and molecules. Their importance in maintaining immune homeostasis and the overall health of an organism is clear. However, Tregs may also be involved in the pathogenesis of malignancies as now compelling evidence shows that tumors induce or recruit CD4+ Tregs to block immune priming and antitumor effectors. Efforts are underway to develop approaches that specifically inhibit the function of tumor-associated Tregs which could lead to an increased capability of the body’s immune system to respond to tumors but without off-target immune-related pathologies (i.e., autoimmune disease). In this review, the biology of human CD4+ Tregs is discussed along with their involvement in malignancies and emerging strategies to block their function.
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Keywords {🔍}

google, scholar, pubmed, cas, cells, regulatory, cancer, immunol, patients, human, cdcd, immunity, med, cell, immune, res, foxp, exp, tumor, clin, blood, peripheral, nat, rev, breast, ovarian, carcinoma, function, article, tregs, lymphocytes, immunotherapy, disis, knutson, induction, melanoma, syndrome, tumors, tumour, ziegler, role, romagnani, sakaguchi, interleukin, immunother, factor, ipex, protein, tcell, responses,

Topics {✒️}

tumor-infiltrating foxp3+cd25+cd4+ regulatory pre-existing t-cell immunity t-cell-mediated antitumor immunity forkhead/winged-helix protein cd4+cd25high regulatory t-cells tumor-draining lymph nodes month download article/chapter tgf-beta-producing regulatory target immune-related pathologies lasting immune-mediated rejection tetramer+ p53 peptide-specific cyclophosphamide-facilitated adoptive immunotherapy inducing t-cell tolerance her2/neu-derived peptide agonistic anti-gitr mab vaccine-mediated antitumor immunity infiltrating cd4+ t-cells human cd4+cd25high regulatory stimulated human cd4+cd25 il-10-producing cd4+cd25+ foxp3 expressing cd4+cd25 lymphocyte-recognized antigen system late-stage ovarian cancer class ii tetramers cd4+cd25+ regulatory thymocytes ovarian cancer-specific cytotoxic tgf-beta 1 plays shape tumour immunogenicity interleukin-2 receptor alpha privacy choices/manage cookies basiliximab versus placebo article cancer immunology sentinel lymph nodes tumour lymphocytic infiltrate existent t-cell renal allograft recipients independent prognostic factor cell-mediated immunity immune suppressive activity immunologically mediated regression full article pdf t-cell responses malignant pleural effusion recombinant immunotoxin lmb-2 acute cellular rejection quantify antigen-specific infiltrating ductal carcinoma x-linked syndrome renal cell carcinoma poorly immunogenic melanoma

Questions {❓}

Moller G (1988) Do suppressor T cells exist?
Tipping the balance in autoimmunity: are regulatory t cells the cause, the cure, or both?

Schema {🗺️}

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