We are analyzing https://link.springer.com/article/10.1007/s00262-005-0110-x.

Title:
Tumor escape mechanisms in prostate cancer | Cancer Immunology, Immunotherapy
Description:
Numerous immunotherapy trials have been carried out in prostate cancer (PC) patients, with induction of antigen-specific T cells in some cases. Despite this capability, limited success is seen in terms of tumor regression or survival. In this review, we discuss the evidence for tumor escape strategies that may contribute to vaccine failure in the setting of PC. These include defects in antigen presentation, production of immunosuppressive substances, induction of T cell death, T cell receptor dysfunction, and the presence of tolerogenic dendritic cells and regulatory T cells inside prostate tumors. It is clear that novel strategies aimed at preventing tumor escape, such as small molecular weight inhibitors of immunosuppressive molecules, adoptive transfer of TCR transgenic T cells, removal of Tregs, combined with anti-androgen therapy and prostate-specific vaccines, need to be examined further in PC patients.
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Keywords {🔍}

cancer, google, scholar, pubmed, prostate, cas, article, cells, tumor, res, expression, patients, immunotherapy, cell, dendritic, immunol, urol, human, clin, immune, escape, nitric, oxide, antigen, immunother, interleukin, miller, immunity, carcinoma, synthase, huland, shurin, privacy, cookies, content, pisa, therapy, access, int, vaccination, clinical, factor, gene, urology, lymphocytes, prostatic, liu, growth, regulation, wang,

Topics {✒️}

flt3-ligand/cd40-ligand immunotherapy month download article/chapter article cancer immunology signal-transducing zeta chains transforming growth factor-beta1 hormone-refractory prostate cancer fas/fas ligand interactions tumor-host immune interactions tumor-induced immune dysfunction antigen-loaded dendritic cells influence tumor regression/progression tumour-infiltrating lymphocytes t-lymphocyte subset infiltration monocyte-derived dendritic cells blocking t-cell activation prevents long-term survival prostate-specific vaccines full article pdf high-grade prostate cancer cell-based vaccines psa-based vaccines privacy choices/manage cookies tumour escape van de rijn humoral immune responses recombinant human psa dendritic cell immunotherapy prostate cancer progression primary prostate cancer cell receptor dysfunction nitric oxide synthase nitric oxide synthase-2 human solid tumors orthotopic mouse model /ii clinical trials swedish cancer society human prostate cancer situ gene therapy fas-mediated suicide prostate cancer cells dendritic cell dysfunction transgenic mouse model beta-2 microglobulin expression tolerogenic dendritic cells natural killer cells advanced prostate cancer prostate cancer antigens preventing tumor escape miller & pavel pisa defective antigen processing

Questions {❓}

Antony PA, Restifo NP (2002) Do CD4+ CD25+ immunoregulatory T cells hinder tumor immunotherapy?
Lutz MB, Schuler G (2002) Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?
Pawelec G (2004) Tumour escape: antitumour effectors too much of a good thing?

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         description:Numerous immunotherapy trials have been carried out in prostate cancer (PC) patients, with induction of antigen-specific T cells in some cases. Despite this capability, limited success is seen in terms of tumor regression or survival. In this review, we discuss the evidence for tumor escape strategies that may contribute to vaccine failure in the setting of PC. These include defects in antigen presentation, production of immunosuppressive substances, induction of T cell death, T cell receptor dysfunction, and the presence of tolerogenic dendritic cells and regulatory T cells inside prostate tumors. It is clear that novel strategies aimed at preventing tumor escape, such as small molecular weight inhibitors of immunosuppressive molecules, adoptive transfer of TCR transgenic T cells, removal of Tregs, combined with anti-androgen therapy and prostate-specific vaccines, need to be examined further in PC patients.
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