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Title:
Amyloid pathology related to aberrant structure-function coupling of brain networks in Alzheimerās disease: insights from [18F]-florbetapir PET imaging | European Journal of Nuclear Medicine and Molecular Imaging
Description:
Purpose Brain structure-function coupling (SFC), which reflects the degree to which anatomical structure supports neural function, is an emerging imaging marker in neurodegenerative diseases. However, its pathological underpinnings in Alzheimerās disease (AD) remain poorly understood. This study aimed to examine the association among amyloid pathology, SFC disruption and cognitive decline. Methods We included 173 participants from the SILCODE cohort, comprising cognitively unimpaired (CU) and cognitively impaired (CI) individuals. Amyloid pathology was quantified using [18F]-florbetapir PET standardized uptake value ratios (SUVR). Structural connectivity (SC) was derived from diffusion-weighted MRI with probabilistic tractography, while functional connectivity (FC) was calculated from resting-state functional MRI. SFC was defined as the coefficient of determination from linear models predicting FC based on SC at regional level. Linear regression and mediation analyses were conducted to assess relationships between amyloid pathology, SFC, and multiple cognitive performances. Results Compared to CU individuals, CI participants exhibited increased regional SFC primarily within the default mode network regions (pā<ā0.05). In CI participants, amyloid pathology correlated with SFC across occipital lobe, precuneus and temporoparietal regions, which was specific by APOE ε4 status (pā<ā0.05). Mediation analyses revealed that SFC partially mediated the relationship between amyloid pathology and cognitive impairment (abMoCAāB = -0.14, 95% CI [-0.27, -0.02]). Similar findings were replicated with plasma markers. Conclusion Amyloid pathology may underlie SFC disruptions, contributing to cognitive decline in AD. These findings suggest that SFC may serve as a potential biomarker for amyloid-related neurodegeneration and cognitive impairment. Trial registration The SILCODE is listed on the ClinicalTrials.gov registry (SILCODE: NCT03370744).
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article, pubmed, google, scholar, alzheimers, brain, disease, wang, cognitive, amyloid, cas, central, china, chen, imaging, beijing, research, functional, network, medical, coupling, impairment, zhang, connectivity, neurol, nat, neuroimage, pathology, structurefunction, networks, han, sfc, study, human, university, huang, authors, hospital, ying, access, open, biomarkers, author, rev, connectome, mudanjiang, content, haojie, shu, decline,
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month download article/chapter resting-state functional mri aberrant structure-function coupling [18f]-florbetapir pet imaging org/journals/neurology/articles/ zhang regional structure-function coupling semi-quantitative amyloid pet sino-german cooperation grant brain structure-function coupling china-japan friendship hospital structural-functional connectivity decoupling 18f-florbetapir pet longitudinal β-amyloid change open research fund state key laboratory alzheimer-related cortical destruction amyloid-related neurodegeneration article european journal cognitively normal elderly functional connectivity toolbox full article pdf open software framework structureāfunction coupling structure-function coupling clinical medical sciences privacy choices/manage cookies structuralāfunctional coupling beijing chao-yang hospital comprising cognitively unimpaired neurodegeneration access structureāfunction tethering structure predict function amyloid pathology related scientific research project medical ethics committee ni shu functional connectivity gradients neurodegenerative diseases holds exclusive rights amyloid-β deposition electronic supplementary material prognostic plasma biomarkers cortical network topology cascading network failure central hospital related subjects shenzhen bay laboratory molecular imaging aims connectivity-function relationship brain network communication
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headline:Amyloid pathology related to aberrant structure-function coupling of brain networks in Alzheimerās disease: insights from [18F]-florbetapir PET imaging
description:Brain structure-function coupling (SFC), which reflects the degree to which anatomical structure supports neural function, is an emerging imaging marker in neurodegenerative diseases. However, its pathological underpinnings in Alzheimerās disease (AD) remain poorly understood. This study aimed to examine the association among amyloid pathology, SFC disruption and cognitive decline. We included 173 participants from the SILCODE cohort, comprising cognitively unimpaired (CU) and cognitively impaired (CI) individuals. Amyloid pathology was quantified using [18F]-florbetapir PET standardized uptake value ratios (SUVR). Structural connectivity (SC) was derived from diffusion-weighted MRI with probabilistic tractography, while functional connectivity (FC) was calculated from resting-state functional MRI. SFC was defined as the coefficient of determination from linear models predicting FC based on SC at regional level. Linear regression and mediation analyses were conducted to assess relationships between amyloid pathology, SFC, and multiple cognitive performances. Compared to CU individuals, CI participants exhibited increased regional SFC primarily within the default mode network regions (pā<ā0.05). In CI participants, amyloid pathology correlated with SFC across occipital lobe, precuneus and temporoparietal regions, which was specific by APOE ε4 status (pā<ā0.05). Mediation analyses revealed that SFC partially mediated the relationship between amyloid pathology and cognitive impairment (abMoCAāB = -0.14, 95% CI [-0.27, -0.02]). Similar findings were replicated with plasma markers. Amyloid pathology may underlie SFC disruptions, contributing to cognitive decline in AD. These findings suggest that SFC may serve as a potential biomarker for amyloid-related neurodegeneration and cognitive impairment. The SILCODE is listed on the ClinicalTrials.gov registry (SILCODE: NCT03370744).
datePublished:2025-03-07T00:00:00Z
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[
F]-florbetapir
Amyloid
Plasma biomarkers
Structure-function coupling
Alzheimerās disease
SILCODE
Nuclear Medicine
Imaging / Radiology
Orthopedics
Cardiology
Oncology
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headline:Amyloid pathology related to aberrant structure-function coupling of brain networks in Alzheimerās disease: insights from [18F]-florbetapir PET imaging
description:Brain structure-function coupling (SFC), which reflects the degree to which anatomical structure supports neural function, is an emerging imaging marker in neurodegenerative diseases. However, its pathological underpinnings in Alzheimerās disease (AD) remain poorly understood. This study aimed to examine the association among amyloid pathology, SFC disruption and cognitive decline. We included 173 participants from the SILCODE cohort, comprising cognitively unimpaired (CU) and cognitively impaired (CI) individuals. Amyloid pathology was quantified using [18F]-florbetapir PET standardized uptake value ratios (SUVR). Structural connectivity (SC) was derived from diffusion-weighted MRI with probabilistic tractography, while functional connectivity (FC) was calculated from resting-state functional MRI. SFC was defined as the coefficient of determination from linear models predicting FC based on SC at regional level. Linear regression and mediation analyses were conducted to assess relationships between amyloid pathology, SFC, and multiple cognitive performances. Compared to CU individuals, CI participants exhibited increased regional SFC primarily within the default mode network regions (pā<ā0.05). In CI participants, amyloid pathology correlated with SFC across occipital lobe, precuneus and temporoparietal regions, which was specific by APOE ε4 status (pā<ā0.05). Mediation analyses revealed that SFC partially mediated the relationship between amyloid pathology and cognitive impairment (abMoCAāB = -0.14, 95% CI [-0.27, -0.02]). Similar findings were replicated with plasma markers. Amyloid pathology may underlie SFC disruptions, contributing to cognitive decline in AD. These findings suggest that SFC may serve as a potential biomarker for amyloid-related neurodegeneration and cognitive impairment. The SILCODE is listed on the ClinicalTrials.gov registry (SILCODE: NCT03370744).
datePublished:2025-03-07T00:00:00Z
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keywords:
[
F]-florbetapir
Amyloid
Plasma biomarkers
Structure-function coupling
Alzheimerās disease
SILCODE
Nuclear Medicine
Imaging / Radiology
Orthopedics
Cardiology
Oncology
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