We are analyzing https://link.springer.com/article/10.1007/s00253-023-12484-6.

Title:
Identification of volatile biomarkers of Trichomonas vaginalis infection in vaginal discharge and urine | Applied Microbiology and Biotechnology
Description:
Abstract Trichomoniasis, a disease caused by Trichomonas vaginalis, is the most common non-viral sexually transmitted infection worldwide. The importance of its diagnosis lies in its ease of transmission and the absence of symptoms in most cases, as occurs in men, which have a significant role as asymptomatic carriers. The most widely used diagnostic methods are the fresh examination of vaginal or urethral secretions and molecular techniques. However, as they have some disadvantages and, sometimes, low sensitivity, new trichomoniasis diagnostic methods are necessary. Volatile organic compounds in clinical samples are effective in the diagnosis of different diseases. This work aimed to study, for the first time, those present in vaginal discharge and urine of patients with Trichomonas vaginalis infection to look for volatile biomarkers. The results showed that volatile compounds such as 2-methyl-1-propanol and cyclohexanone could serve as biomarkers in vaginal discharge samples, as well as 2-octen-1-ol and 3-nonanone in urine. Moreover, 3-hydroxy-2,4,4-trimethylpentyl 2-methylpropanoate found in vaginal discharge, highly correlated to positive patients, is also highly related to urines of patients with trichomoniasis. The biomarkers described in this study might be a promising diagnostic tool. Key Points • The incidence of Trichomonas vaginalis infection is increasing • Trichomonas vaginalis VOC study in vaginal discharge and urine was performed • The identification of volatile biomarkers could allow a new diagnostic method
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Keywords {🔍}

samples, urine, vaginal, trichomonas, vaginalis, discharge, volatile, compounds, patients, article, positive, table, pubmed, analysis, google, scholar, trichomoniasis, negative, infection, parasite, vip, higher, cas, biomarkers, vocs, related, detected, alcohols, diagnostic, present, data, found, medium, methods, women, presence, dataset, plsda, score, study, obtained, vips, asymptomatic, clinical, sample, secondary, transport, scores, identification, diagnosis,

Topics {✒️}

universidad de sevilla/cbua article rubio-sánchez rocío ríos-reina article download pdf open access publishing full size table dr rocío ríos headspace-solid phase microextraction microbiología clínica departamento de nutrición pls-da model made universidad de sevilla cu conducted gc–ms bd max system bd vacutainer tube facultad de farmacia quadrupole mass spectrometer privacy choices/manage cookies human urogenital tract urogenital tract infection 20 μm film thickness pls-da models carried mass spectral library mass spectra obtained full access volatile organic compounds multiple infections alter higher consumption/degradation caused lower values observed ríos-reina world health organization avoid cross-contamination detecting infectious diseases current diagnostic methods gas mixture future research analyzing nucleic acid hybridization main chemical groups promising diagnostic technique trichomonas vaginalis affects trichomonas vaginalis consumes trichomonas vaginalis origins metabolic disorders hs-spme extraction pls-da models electron transport chain potential volatile biomarkers molecular b-ology pls-da model specific clinical sign

Questions {❓}

Soper D (2004) Trichomoniasis: under control or undercontrolled?

Schema {🗺️}

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         description:Trichomoniasis, a disease caused by Trichomonas vaginalis, is the most common non-viral sexually transmitted infection worldwide. The importance of its diagnosis lies in its ease of transmission and the absence of symptoms in most cases, as occurs in men, which have a significant role as asymptomatic carriers. The most widely used diagnostic methods are the fresh examination of vaginal or urethral secretions and molecular techniques. However, as they have some disadvantages and, sometimes, low sensitivity, new trichomoniasis diagnostic methods are necessary. Volatile organic compounds in clinical samples are effective in the diagnosis of different diseases. This work aimed to study, for the first time, those present in vaginal discharge and urine of patients with Trichomonas vaginalis infection to look for volatile biomarkers. The results showed that volatile compounds such as 2-methyl-1-propanol and cyclohexanone could serve as biomarkers in vaginal discharge samples, as well as 2-octen-1-ol and 3-nonanone in urine. Moreover, 3-hydroxy-2,4,4-trimethylpentyl 2-methylpropanoate found in vaginal discharge, highly correlated to positive patients, is also highly related to urines of patients with trichomoniasis. The biomarkers described in this study might be a promising diagnostic tool. • The incidence of Trichomonas vaginalis infection is increasing • Trichomonas vaginalis VOC study in vaginal discharge and urine was performed • The identification of volatile biomarkers could allow a new diagnostic method
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      headline:Identification of volatile biomarkers of Trichomonas vaginalis infection in vaginal discharge and urine
      description:Trichomoniasis, a disease caused by Trichomonas vaginalis, is the most common non-viral sexually transmitted infection worldwide. The importance of its diagnosis lies in its ease of transmission and the absence of symptoms in most cases, as occurs in men, which have a significant role as asymptomatic carriers. The most widely used diagnostic methods are the fresh examination of vaginal or urethral secretions and molecular techniques. However, as they have some disadvantages and, sometimes, low sensitivity, new trichomoniasis diagnostic methods are necessary. Volatile organic compounds in clinical samples are effective in the diagnosis of different diseases. This work aimed to study, for the first time, those present in vaginal discharge and urine of patients with Trichomonas vaginalis infection to look for volatile biomarkers. The results showed that volatile compounds such as 2-methyl-1-propanol and cyclohexanone could serve as biomarkers in vaginal discharge samples, as well as 2-octen-1-ol and 3-nonanone in urine. Moreover, 3-hydroxy-2,4,4-trimethylpentyl 2-methylpropanoate found in vaginal discharge, highly correlated to positive patients, is also highly related to urines of patients with trichomoniasis. The biomarkers described in this study might be a promising diagnostic tool. • The incidence of Trichomonas vaginalis infection is increasing • Trichomonas vaginalis VOC study in vaginal discharge and urine was performed • The identification of volatile biomarkers could allow a new diagnostic method
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         Volatile organic compounds
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         Microbial Genetics and Genomics
         Biotechnology
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