We are analyzing https://link.springer.com/article/10.1007/s00251-021-01237-2.

Title:
Secreted immunoglobulin domain effector molecules of invertebrates and management of gut microbial ecology | Immunogenetics
Description:
The origins of a “pass-through” gut in early bilaterians facilitated the exploration of new habitats, motivated the innovation of feeding styles and behaviors, and helped drive the evolution of more complex organisms. The gastrointestinal tract has evolved to consist of a series of interwoven exchanges between nutrients, host immunity, and an often microbe-rich environmental interface. Not surprisingly, animals have expanded their immune repertoires to include soluble effectors that can be secreted into luminal spaces, e.g., in the gut, facilitating interactions with microbes in ways that influence their settlement dynamics, virulence, and their interaction with other microbes. The immunoglobulin (Ig) domain, which is also found in some non-immune molecules, is recognized as one of the most versatile recognition domains lying at the interface of innate and adaptive immunity; among vertebrates, secreted Igs are known to play crucial roles in the management of gut microbial communities. In this mini-review, we will focus on secreted immune effectors possessing Ig-like domains in invertebrates, such as the fibrinogen-related effector proteins first described in the gastropod Biomphalaria glabrata, the Down syndrome cellular adhesion molecule first described in the arthropod, Drosophila melanogaster, and the variable region-containing chitin-binding proteins of the protochordates. We will highlight our current understanding of their function and their potential role, if not yet recognized, in the establishment and maintenance of host-microbial interfaces and argue that these Igs are likely also essential to microbiome management.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, article, google, scholar, cas, immunol, immune, central, gut, immunity, dishaw, immunoglobulin, evolution, proteins, microbiota, cell, interactions, innate, system, biol, cannon, comp, dev, secreted, liberti, domains, variable, rev, nat, httpsdoiorgjdci, domain, molecules, microbial, receptor, dscam, httpsdoiorgs, content, host, role, httpsdoiorg, superfamily, litman, front, plos, intestinal, privacy, cookies, immunogenetics, effector, manuscript,

Topics {✒️}

month download article/chapter c-type lectin maintains insect-immune protein belonging humoral immune responses heterogeneous carbohydrate-binding proteins hemocyte-specific frep13 abrogates fibrinogen-related effector proteins immune-type receptor secreted immune effectors litopenaeus vannamei dscam host gut-bacteria interactions article immunogenetics aims microbe-rich environmental interface bacterial-fungal interactions article liberti full article pdf immune receptor diversity immune effector system interaction molecules hypervariable immunoglobulin domain cell adhesion molecules immune evasion innate immune receptors exogenous bacterial population adema cm host-microbe interactions innate immune system innate immune systems innate host defense host-microbial interfaces privacy choices/manage cookies immune-directed support snail biomphalaria glabrata dishaw lj parasite-microbiota interactions chitin-binding proteins flores-torres ja gastropod biomphalaria glabrata reconstructing immune phylogeny mosquito midgut microbiota gut microbiota unaffected include soluble effectors rich microbial communities cell surface recognition immune molecules early bilaterians facilitated lectin complement pathway mediates biofilm formation gut microbial communities gut microbial ecology

Questions {❓}

Mussmann R, Du Pasquier L, Hsu E (1996) Is Xenopus IgX an analog of IgA?
The Gut Microbiome and Its Marriage to the Immune System: Can We Change It All?

Schema {🗺️}

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         description:The origins of a “pass-through” gut in early bilaterians facilitated the exploration of new habitats, motivated the innovation of feeding styles and behaviors, and helped drive the evolution of more complex organisms. The gastrointestinal tract has evolved to consist of a series of interwoven exchanges between nutrients, host immunity, and an often microbe-rich environmental interface. Not surprisingly, animals have expanded their immune repertoires to include soluble effectors that can be secreted into luminal spaces, e.g., in the gut, facilitating interactions with microbes in ways that influence their settlement dynamics, virulence, and their interaction with other microbes. The immunoglobulin (Ig) domain, which is also found in some non-immune molecules, is recognized as one of the most versatile recognition domains lying at the interface of innate and adaptive immunity; among vertebrates, secreted Igs are known to play crucial roles in the management of gut microbial communities. In this mini-review, we will focus on secreted immune effectors possessing Ig-like domains in invertebrates, such as the fibrinogen-related effector proteins first described in the gastropod Biomphalaria glabrata, the Down syndrome cellular adhesion molecule first described in the arthropod, Drosophila melanogaster, and the variable region-containing chitin-binding proteins of the protochordates. We will highlight our current understanding of their function and their potential role, if not yet recognized, in the establishment and maintenance of host-microbial interfaces and argue that these Igs are likely also essential to microbiome management.
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         Cell Biology
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