We are analyzing https://link.springer.com/article/10.1007/s00251-018-1078-y.

Title:
Thymus-specific serine protease, a protease that shapes the CD4 T cell repertoire | Immunogenetics
Description:
The lifespan of T cells is determined by continuous interactions of their T cell receptors (TCR) with self-peptide-MHC (self-pMHC) complexes presented by different subsets of antigen-presenting cells (APC). In the thymus, developing thymocytes are positively selected through recognition of self-pMHC presented by cortical thymic epithelial cells (cTEC). They are subsequently negatively selected by medullary thymic epithelial cells (mTEC) or thymic dendritic cells (DC) presenting self-pMHC complexes. In the periphery, the homeostasis of mature T cells is likewise controlled by the interaction of their TCR with self-pMHC complexes presented by lymph node stromal cells while they may be tolerized by DC presenting tissue-derived self-antigens. To perform these tasks, the different subsets of APC are equipped with distinct combination of antigen processing enzymes and consequently present specific repertoire of self-peptides. Here, we discuss one such antigen processing enzyme, the thymus-specific serine protease (TSSP), which is predominantly expressed by thymic stromal cells. In thymic DC and TEC, TSSP edits the repertoire of peptide presented by class II molecules and thus shapes the CD4 T cell repertoire.
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pubmed, article, google, scholar, cas, central, cell, immunol, cells, thymic, protease, guerder, diabetes, gene, serine, antigen, mice, expression, thymusspecific, tcell, repertoire, carrier, peptide, class, type, toulouse, processing, nat, content, sylvie, thymus, epithelial, haskins, malissen, selection, nature, privacy, cookies, research, hassel, access, tolerance, receptor, complex, eur, bowlus, biol, genes, mhc, nod,

Topics {✒️}

month download article/chapter thymus-specific serine protease genome-wide meta-analysis approach autoantigen-specific t-cell receptors organ-specific cdna library t-cell repertoire specific cd4 t-cell epitopes single-cell genomics reveal central tolerance spares private high-avidity cd4 major histocompatibility complex antigen processing cd8-positive thymic dendritic cells class ii gene article immunogenetics aims lie ba full article pdf class ii molecules proline-specific peptidases genome-wide association study cortical epithelial cells antigen-presenting cell subsets t-cell responses dc presenting tissue-derived medical research foundation t-cell development thymic stromal cells privacy choices/manage cookies de jager pl cantu de leon idex toulouse university present specific repertoire cells cd4-positive antigen presentation access znf804a regulates expression de geus ej human dpp7 reveal french ms society cell receptor repertoire functional endogenous cd4 article guerder antigen processing enzyme cell tolerance cd4 institut paoli-calmettes antigen-presenting cells cell specificities reactive gene expression profiling sylvie guerder rag1-deficient thymuses myelin oligodendrocyte glycoprotein

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         description:The lifespan of T cells is determined by continuous interactions of their T cell receptors (TCR) with self-peptide-MHC (self-pMHC) complexes presented by different subsets of antigen-presenting cells (APC). In the thymus, developing thymocytes are positively selected through recognition of self-pMHC presented by cortical thymic epithelial cells (cTEC). They are subsequently negatively selected by medullary thymic epithelial cells (mTEC) or thymic dendritic cells (DC) presenting self-pMHC complexes. In the periphery, the homeostasis of mature T cells is likewise controlled by the interaction of their TCR with self-pMHC complexes presented by lymph node stromal cells while they may be tolerized by DC presenting tissue-derived self-antigens. To perform these tasks, the different subsets of APC are equipped with distinct combination of antigen processing enzymes and consequently present specific repertoire of self-peptides. Here, we discuss one such antigen processing enzyme, the thymus-specific serine protease (TSSP), which is predominantly expressed by thymic stromal cells. In thymic DC and TEC, TSSP edits the repertoire of peptide presented by class II molecules and thus shapes the CD4 T cell repertoire.
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            CD4 T cell tolerance
            CD4 T cell-positive selection
            Autoimmunity
            Dendritic cells
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            Immunology
            Human Genetics
            Gene Function
            Cell Biology
            Allergology
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      headline:Thymus-specific serine protease, a protease that shapes the CD4 T cell repertoire
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         CD4 T cell tolerance
         CD4 T cell-positive selection
         Autoimmunity
         Dendritic cells
         Thymic epithelial cells
         Immunology
         Human Genetics
         Gene Function
         Cell Biology
         Allergology
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