We are analyzing https://link.springer.com/article/10.1007/s00251-011-0513-0.

Title:
Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes | Immunogenetics
Description:
Previous studies have attempted to define human leukocyte antigen (HLA) class II supertypes, analogous to the case for class I, on the basis of shared peptide-binding motifs or structure. In the present study, we determined the binding capacity of a large panel of non-redundant peptides for a set of 27 common HLA DR, DQ, and DP molecules. The measured binding data were then used to define class II supertypes on the basis of shared binding repertoires. Seven different supertypes (main DR, DR4, DRB3, main DQ, DQ7, main DP, and DP2) were defined. The molecules associated with the respective supertypes fell largely along lines defined by MHC locus and reflect, in broad terms, commonalities in reported peptide-binding motifs. Repertoire overlaps between molecules within the same class II supertype were found to be similar in magnitude to what has been observed for HLA class I supertypes. Surprisingly, however, the degree to which repertoires between molecules in the different class II supertypes also overlapped was found to be five to tenfold higher than repertoire overlaps noted between molecules in different class I supertypes. These results highlight a high degree of repertoire overlap amongst all HLA class II molecules, perhaps reflecting binding in multiple registers, and more pronounced dependence on backbone interactions rather than peptide anchor residues. This fundamental difference between HLA class I and class II would not have been predicted on the basis of analysis of either binding motifs or the sequence/predicted structures of the HLA molecules.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Books & Literature

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

google, scholar, pubmed, cas, article, class, hla, sette, binding, immunol, sidney, molecules, supertypes, mhc, peptide, human, oseroff, southwood, hladr, motifs, peptides, del, immunogenetics, specificity, guercio, analysis, antigen, peters, peptidebinding, repertoires, epitopes, grey, chung, common, histocompatibility, alleles, structural, privacy, cookies, content, data, functional, leukocyte, repertoire, basis, structure, interactions, polymorphism, nature, protein,

Topics {✒️}

month download article/chapter overlapping peptide-binding repertoires reported peptide-binding motifs shared peptide-binding motifs hla-dr beta chain cd8 t-cell epitopes overlapping binding repertoires hla molecules dqa10501/b10201 dqa10301/b10302 share human leucocyte antigen human ia antigens class ii mhcs full article pdf mouse mhc class worldwide human population peptide binding specificities major hla class privacy choices/manage cookies peptide/hla class class ii supertypes peptide-binding motifs mhc/peptide interactions naturally processed peptides class ii supertype common structural motifs shared binding repertoires article immunogenetics aims antigen fine specificity drb10301 molecules recognize peptide–mhc complexes common hla molecules extensive hla class hla-dr molecule dr binding epitopes peptide-dr interactions influenza virus peptide hla-dr13 alleles hla dr alleles 1-specific binding motif peptide-binding specificity peptide binding specificity cell epitopes access alternative specific submotifs hla-dr molecules promiscuous antigenic peptides natural peptides isolated viral ctl epitopes type hla supertypes amino acid sequence article greenbaum

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes
         description:Previous studies have attempted to define human leukocyte antigen (HLA) class II supertypes, analogous to the case for class I, on the basis of shared peptide-binding motifs or structure. In the present study, we determined the binding capacity of a large panel of non-redundant peptides for a set of 27 common HLA DR, DQ, and DP molecules. The measured binding data were then used to define class II supertypes on the basis of shared binding repertoires. Seven different supertypes (main DR, DR4, DRB3, main DQ, DQ7, main DP, and DP2) were defined. The molecules associated with the respective supertypes fell largely along lines defined by MHC locus and reflect, in broad terms, commonalities in reported peptide-binding motifs. Repertoire overlaps between molecules within the same class II supertype were found to be similar in magnitude to what has been observed for HLA class I supertypes. Surprisingly, however, the degree to which repertoires between molecules in the different class II supertypes also overlapped was found to be five to tenfold higher than repertoire overlaps noted between molecules in different class I supertypes. These results highlight a high degree of repertoire overlap amongst all HLA class II molecules, perhaps reflecting binding in multiple registers, and more pronounced dependence on backbone interactions rather than peptide anchor residues. This fundamental difference between HLA class I and class II would not have been predicted on the basis of analysis of either binding motifs or the sequence/predicted structures of the HLA molecules.
         datePublished:2011-02-09T00:00:00Z
         dateModified:2011-02-09T00:00:00Z
         pageStart:325
         pageEnd:335
         sameAs:https://doi.org/10.1007/s00251-011-0513-0
         keywords:
            MHC
            HLA class I
            HLA class II
            Peptide binding
            T cell epitopes
            Immunology
            Human Genetics
            Gene Function
            Cell Biology
            Allergology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00251-011-0513-0/MediaObjects/251_2011_513_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00251-011-0513-0/MediaObjects/251_2011_513_Fig2_HTML.gif
         isPartOf:
            name:Immunogenetics
            issn:
               1432-1211
               0093-7711
            volumeNumber:63
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Jason Greenbaum
               affiliation:
                     name:La Jolla Institute for Allergy and Immunology
                     address:
                        name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:John Sidney
               affiliation:
                     name:La Jolla Institute for Allergy and Immunology
                     address:
                        name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jolan Chung
               affiliation:
                     name:La Jolla Institute for Allergy and Immunology
                     address:
                        name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Christian Brander
               affiliation:
                     name:Hospital Universitari Germans Trias i Pujol
                     address:
                        name:AIDS Research Institute, Fundacio irsiCaixa-HIVACAT, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bjoern Peters
               affiliation:
                     name:La Jolla Institute for Allergy and Immunology
                     address:
                        name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alessandro Sette
               affiliation:
                     name:La Jolla Institute for Allergy and Immunology
                     address:
                        name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes
      description:Previous studies have attempted to define human leukocyte antigen (HLA) class II supertypes, analogous to the case for class I, on the basis of shared peptide-binding motifs or structure. In the present study, we determined the binding capacity of a large panel of non-redundant peptides for a set of 27 common HLA DR, DQ, and DP molecules. The measured binding data were then used to define class II supertypes on the basis of shared binding repertoires. Seven different supertypes (main DR, DR4, DRB3, main DQ, DQ7, main DP, and DP2) were defined. The molecules associated with the respective supertypes fell largely along lines defined by MHC locus and reflect, in broad terms, commonalities in reported peptide-binding motifs. Repertoire overlaps between molecules within the same class II supertype were found to be similar in magnitude to what has been observed for HLA class I supertypes. Surprisingly, however, the degree to which repertoires between molecules in the different class II supertypes also overlapped was found to be five to tenfold higher than repertoire overlaps noted between molecules in different class I supertypes. These results highlight a high degree of repertoire overlap amongst all HLA class II molecules, perhaps reflecting binding in multiple registers, and more pronounced dependence on backbone interactions rather than peptide anchor residues. This fundamental difference between HLA class I and class II would not have been predicted on the basis of analysis of either binding motifs or the sequence/predicted structures of the HLA molecules.
      datePublished:2011-02-09T00:00:00Z
      dateModified:2011-02-09T00:00:00Z
      pageStart:325
      pageEnd:335
      sameAs:https://doi.org/10.1007/s00251-011-0513-0
      keywords:
         MHC
         HLA class I
         HLA class II
         Peptide binding
         T cell epitopes
         Immunology
         Human Genetics
         Gene Function
         Cell Biology
         Allergology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00251-011-0513-0/MediaObjects/251_2011_513_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00251-011-0513-0/MediaObjects/251_2011_513_Fig2_HTML.gif
      isPartOf:
         name:Immunogenetics
         issn:
            1432-1211
            0093-7711
         volumeNumber:63
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jason Greenbaum
            affiliation:
                  name:La Jolla Institute for Allergy and Immunology
                  address:
                     name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:John Sidney
            affiliation:
                  name:La Jolla Institute for Allergy and Immunology
                  address:
                     name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jolan Chung
            affiliation:
                  name:La Jolla Institute for Allergy and Immunology
                  address:
                     name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christian Brander
            affiliation:
                  name:Hospital Universitari Germans Trias i Pujol
                  address:
                     name:AIDS Research Institute, Fundacio irsiCaixa-HIVACAT, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bjoern Peters
            affiliation:
                  name:La Jolla Institute for Allergy and Immunology
                  address:
                     name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alessandro Sette
            affiliation:
                  name:La Jolla Institute for Allergy and Immunology
                  address:
                     name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Immunogenetics
      issn:
         1432-1211
         0093-7711
      volumeNumber:63
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:La Jolla Institute for Allergy and Immunology
      address:
         name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
         type:PostalAddress
      name:La Jolla Institute for Allergy and Immunology
      address:
         name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
         type:PostalAddress
      name:La Jolla Institute for Allergy and Immunology
      address:
         name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
         type:PostalAddress
      name:Hospital Universitari Germans Trias i Pujol
      address:
         name:AIDS Research Institute, Fundacio irsiCaixa-HIVACAT, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
         type:PostalAddress
      name:La Jolla Institute for Allergy and Immunology
      address:
         name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
         type:PostalAddress
      name:La Jolla Institute for Allergy and Immunology
      address:
         name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Jason Greenbaum
      affiliation:
            name:La Jolla Institute for Allergy and Immunology
            address:
               name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
               type:PostalAddress
            type:Organization
      name:John Sidney
      affiliation:
            name:La Jolla Institute for Allergy and Immunology
            address:
               name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
               type:PostalAddress
            type:Organization
      name:Jolan Chung
      affiliation:
            name:La Jolla Institute for Allergy and Immunology
            address:
               name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
               type:PostalAddress
            type:Organization
      name:Christian Brander
      affiliation:
            name:Hospital Universitari Germans Trias i Pujol
            address:
               name:AIDS Research Institute, Fundacio irsiCaixa-HIVACAT, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Bjoern Peters
      affiliation:
            name:La Jolla Institute for Allergy and Immunology
            address:
               name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
               type:PostalAddress
            type:Organization
      name:Alessandro Sette
      affiliation:
            name:La Jolla Institute for Allergy and Immunology
            address:
               name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
      name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
      name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
      name:AIDS Research Institute, Fundacio irsiCaixa-HIVACAT, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
      name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
      name:La Jolla Institute for Allergy and Immunology, La Jolla, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(189)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.88s.

LINK . SPRINGER . COM {}