We are analyzing https://link.springer.com/article/10.1007/s00251-008-0330-2.

Title:
MHC motif viewer | Immunogenetics
Description:
In vertebrates, the major histocompatibility complex (MHC) presents peptides to the immune system. In humans, MHCs are called human leukocyte antigens (HLAs), and some of the loci encoding them are the most polymorphic in the human genome. Different MHC molecules present different subsets of peptides, and knowledge of their binding specificities is important for understanding the differences in the immune response between individuals. Knowledge of motifs may be used to identify epitopes, to understand the MHC restriction of epitopes, and to compare the specificities of different MHC molecules. Algorithms that predict which peptides MHC molecules bind have recently been developed and cover many different alleles, but the utility of these algorithms is hampered by the lack of tools for browsing and comparing the specificity of these molecules. We have, therefore, developed a web server, MHC motif viewer, that allows the display of the likely binding motif for all human class I proteins of the loci HLA A, B, C, and E and for MHC class I molecules from chimpanzee (Pan troglodytes), rhesus monkey (Macaca mulatta), and mouse (Mus musculus). Furthermore, it covers all HLA-DR protein sequences. A special viewing feature, MHC fight, allows for display of the specificity of two different MHC molecules side by side. We show how the web server can be used to discover and display surprising similarities as well as differences between MHC molecules within and between different species. The MHC motif viewer is available at http://www.cbs.dtu.dk/biotools/MHCMotifViewer/ .
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

article, mhc, google, scholar, pubmed, cas, class, molecules, immunogenetics, nielsen, binding, epitopes, protein, sequence, privacy, cookies, search, motif, viewer, lund, major, specificity, hla, dois, lundegaard, content, publish, hoof, histocompatibility, human, motifs, display, discover, access, database, sidney, peptide, sette, analysis, data, information, log, journal, research, rapin, morten, complex, peptides, immune, nucleic,

Topics {✒️}

ole lund & morten nielsen month download article/chapter hla-dr protein sequences ec contract fp6-2004-ist-4 class ii access major histocompatibility complex allele-specific motifs revealed class ii epitopes mhc motif viewer full article pdf major hla class biological sequence analysis privacy choices/manage cookies article immunogenetics aims common patr class extensive hla class efficient peptide-mhc hla-dr molecule morten nielsen mhc molecules present article rapin european economic area special viewing feature dk/biotools/mhcmotifviewer/ protein sci 12 gibbs sampling approach locus protein del guercio mf interspecies cross-reactivity conditions privacy policy usage analysis viral ctl epitopes t-cell epitopes display consensus sequences siv-derived epitopes imgt/hla database mhc class mhc molecules side accepting optional cookies article log display surprising similarities article cite human class journal finder publish peptide-binding specificity peptide binding specificity rammensee hg mhc molecules binding motif mhc restriction

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         Human Genetics
         Gene Function
         Cell Biology
         Allergology
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