We are analyzing https://link.springer.com/article/10.1007/s00246-008-9273-5.

Title:
Outcome of Prenatally Diagnosed Isolated Congenital Complete Atrioventricular Block Treated with Transplacental Betamethasone or Ritodrine Therapy | Pediatric Cardiology
Description:
The effectiveness of transplacental drug therapy for prenatally diagnosed isolated congenital complete atrioventricular block (CCAVB) is controversial. Nine cases of prenatal isolated CCAVB were treated from 2002 to 2007. Ritodrine was administered transplacentally to all fetuses and betamethasone to those whose mothers tested positive for maternal anti-SSA/Ro antibodies. Six of the nine patients had an anti-SSA/Ro-positive mother and received transplacental betamethasone 4 mg/day at a median gestational age of 28 weeks (range, 24–31 weeks). No patients exhibited an improvement in the degrees of complete heart block, and one patient died in utero. No serious adverse events occurred. After the mean follow-up period of 1.7 ± 1.3 years, all five patients treated with transplacental betamethasone experienced a good cardiac function, whereas one of the three patients not treated with transplacental betamethasone experienced cardiomyopathy and died at the age of 4 months. Pacemaker implantation was required for seven of the eight live-born infants. Transplacental betamethasone therapy for the patients with isolated CCAVB neither improved the degree of atrioventricular block nor decreased the rate of patients requiring pacemaker implantation, but it probably reduced the risk for the development of myocardial disease.
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Keywords {🔍}

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Topics {✒️}

anti-ssa/ro-positive mother anti-ro/ssa antibodies detected maternal anti-ssa/ro antibodies anti-ssa/ro antibodies month download article/chapter complete atrioventricular block transplacental drug therapy maternal antibody status complete heart block congenital heart block full article pdf anti-la antibodies transplacental betamethasone therapy related subjects privacy choices/manage cookies fetal ventricular pacing staged pacing therapy transplacental betamethasone experienced prenatal isolated ccavb childhood atrioventricular blocks atrioventricular block fetal echocardiographic screening anti-ro hydrops secondary long-term outcome pediatric cardiology live-born infants dexamethasone versus betamethasone european economic area adverse events occurred successful pregnancy recurrence rates obtained structural heart disease check access instant access maternal internal medicine conditions privacy policy mothers tested positive single japanese institution research registry article hayashi high-dose dexamethasone buyon jp accepting optional cookies ki-sung kim median gestational age natural history story retrospective review main content log good cardiac function

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         headline:Outcome of Prenatally Diagnosed Isolated Congenital Complete Atrioventricular Block Treated with Transplacental Betamethasone or Ritodrine Therapy
         description:The effectiveness of transplacental drug therapy for prenatally diagnosed isolated congenital complete atrioventricular block (CCAVB) is controversial. Nine cases of prenatal isolated CCAVB were treated from 2002 to 2007. Ritodrine was administered transplacentally to all fetuses and betamethasone to those whose mothers tested positive for maternal anti-SSA/Ro antibodies. Six of the nine patients had an anti-SSA/Ro-positive mother and received transplacental betamethasone 4 mg/day at a median gestational age of 28 weeks (range, 24–31 weeks). No patients exhibited an improvement in the degrees of complete heart block, and one patient died in utero. No serious adverse events occurred. After the mean follow-up period of 1.7 ± 1.3 years, all five patients treated with transplacental betamethasone experienced a good cardiac function, whereas one of the three patients not treated with transplacental betamethasone experienced cardiomyopathy and died at the age of 4 months. Pacemaker implantation was required for seven of the eight live-born infants. Transplacental betamethasone therapy for the patients with isolated CCAVB neither improved the degree of atrioventricular block nor decreased the rate of patients requiring pacemaker implantation, but it probably reduced the risk for the development of myocardial disease.
         datePublished:2008-07-26T00:00:00Z
         dateModified:2008-07-26T00:00:00Z
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      description:The effectiveness of transplacental drug therapy for prenatally diagnosed isolated congenital complete atrioventricular block (CCAVB) is controversial. Nine cases of prenatal isolated CCAVB were treated from 2002 to 2007. Ritodrine was administered transplacentally to all fetuses and betamethasone to those whose mothers tested positive for maternal anti-SSA/Ro antibodies. Six of the nine patients had an anti-SSA/Ro-positive mother and received transplacental betamethasone 4 mg/day at a median gestational age of 28 weeks (range, 24–31 weeks). No patients exhibited an improvement in the degrees of complete heart block, and one patient died in utero. No serious adverse events occurred. After the mean follow-up period of 1.7 ± 1.3 years, all five patients treated with transplacental betamethasone experienced a good cardiac function, whereas one of the three patients not treated with transplacental betamethasone experienced cardiomyopathy and died at the age of 4 months. Pacemaker implantation was required for seven of the eight live-born infants. Transplacental betamethasone therapy for the patients with isolated CCAVB neither improved the degree of atrioventricular block nor decreased the rate of patients requiring pacemaker implantation, but it probably reduced the risk for the development of myocardial disease.
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         Vascular Surgery
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