We are analyzing https://link.springer.com/article/10.1007/s00239-005-0163-7.

Title:
Getting the Proto-Pax by the Tail | Journal of Molecular Evolution
Description:
Pax genes encode transcription factors governing the determination of different cell types and even organs in the development of multicellular animals. Pax proteins are characterized by the presence of three evolutionarily conserved elements: two DNA-binding domains, the paired domain (PD) and paired-type homeodomain (PtHD), and the short octopeptide sequence (OP) located between PD and PtHD. PD is the defining feature of this class of genes, while OP and/or PtHD may be divergent or absent in some members of the family. Phylogenetic analyses of the PD and PtHD sequences do not distinguish which particular type of the extant Pax genes more resembles the ancestral type. Here we present evidence for the existence of a fourth evolutionarily conserved domain in the Pax proteins, the paired-type homeodomain tail (PHT). Our data also imply that the hypothetical proto-Pax protein most probably exhibited a complex structure, PD-OP-PtHD-PHT, which has been retained in the extant proteins Pax3/7 of the ascidia and lancelet, and Pax7 of the vertebrates. Finally, based on structural considerations, a scenario for the evolutionary emergence of the proto-Pax gene is proposed.
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Keywords {🔍}

google, scholar, article, pubmed, cas, pax, gene, genes, evolution, paired, evol, dev, holland, development, biol, homeobox, proteins, domain, expression, usa, homeodomain, mol, proc, natl, acad, sci, privacy, cookies, content, data, information, journal, cell, family, protein, access, related, hydra, amphioxus, analysis, publish, search, protopax, july, horst, dnabinding, domains, pthd, box, miller,

Topics {✒️}

month download article/chapter paired dna-binding domain midbrain-hindbrain boundary region hypothetical proto-pax protein homeobox transcription factors ancestor-type pax gene dna-binding domains paired-type homeodomain tail extant proteins pax3/7 paired-type homeobox gene full article pdf aristaless-related gene article vorobyov privacy choices/manage cookies amphioxus genomic dna drosophila hydei encode human genome ancestry jürgen horst homeodomain proteins mahon ka paired-type homeodomain paired box genes related subjects optic support cells protein information resource partial paired domain developmentally relevant genes extant pax genes coral pax genes jellyfish podocoryne carnea amphioxus pax-6 gene amphioxus pax gene segmentation gene paired pax proteins ventral neural tube ancient gene duplications rx homeobox gene pax gene diversity evolutionarily conserved elements european economic area reece-hoyes js pharyngeal gill slits reconstructing phylogenetic trees ciona intestinalis ii accession numbers ay235576 proto-pax gene homeobox gene otx anterior neural fold conditions privacy policy mobile minos elements

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