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Title:
Hypovitaminosis D Myopathy Without Biochemical Signs of Osteomalacic Bone Involvement | Calcified Tissue International
Description:
The aims of this study were to investigate myopathy in relation to vitamin D status, and to study the muscular effects of vitamin D treatment on vitamin D-deficient individuals. Further, hypovitaminosis D myopathy was investigated in relation to alkaline phosphatase (ALP), the most commonly used marker for hypovitaminosis D osteopathy. Eight patients with osteomalacia had an isokinetic dynamometer test of all major muscle groups before and after 3 months of vitamin D treatment. The most pronounced improvements in muscle power were seen in the weight-bearing antigravity muscles of the lower limbs. A cross-sectional study was performed among 55 vitamin D-deficient veiled Arab women living in Denmark and 22 Danish controls. An isometric dynamometer model was used for determination of quadriceps muscle power. Both maximal voluntary contraction (MVC) and electrically stimulated values (single twitch, maximal production rate (MPR), and maximal relaxation rate (MRR)) were determined. The women underwent high-dose vitamin D treatment and were retested after 3 and 6 months. Prior to vitamin D treatment all parameters of muscle function in the group of vitamin D-deficient Arab women were significantly reduced compared with Danish controls. MVC: 259.4 Β± 11.0 N (Newton) versus 392.6 Β± 11.4 N (P < 10β6), single twitch: 47.0 Β± 1.8 N versus 74.6 Β± 2.2 N (P < 10β5), MPR 8.9 Β± 0.3 N/10 ms versus 14.3 Β± 0.4 N/10 ms (P < 10β6), MRR 4.5 Β± 0.2 N/10 ms versus 6.2 Β± 0.2 N/10 ms (P < 10β6). Muscle function was affected to a similar degree in women with and without bone involvement (as indicated by elevated ALP). After 3 months of vitamin D treatment all muscle-related parameters improved significantly. After 6 months only MVC was reduced compared with Danish controls (320.7 Β± 14.3 N (P < 0.02)), whereas all other measurements were normalized. Hypovitaminosis D myopathy is a prominent symptom of vitamin D deficiency, and severely impaired muscle function may be present even before biochemical signs of bone disease develop. Full normalization of hypovitaminosis D myopathy demands high-dose vitamin D treatment for 6 months or more. Our findings indicate that serum levels of ALP cannot be used in the screening for hypovitaminosis D myopathy. Assessment of s-25OHD is the only reliable test.
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vitamin, article, myopathy, hypovitaminosis, muscle, denmark, treatment, aarhus, privacy, cookies, function, content, bone, months, women, information, publish, search, study, versus, access, data, log, journal, research, tissue, biochemical, signs, osteomalacic, involvement, glerup, mikkelsen, poulsen, ddeficient, alp, patients, danish, controls, maximal, mvc, deficiency, disease, discover, springer, optional, personal, parties, policy, find, track,
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bone disease develop vitamin d-deficient individuals month download article/chapter weight-bearing antigravity muscles osteomalacic bone involvement related subjects privacy choices/manage cookies full article pdf metabolism cross-sectional study bone involvement major muscle groups european economic area scope submit manuscript isometric dynamometer model maximal voluntary contraction electrically stimulated values maximal production rate maximal relaxation rate significantly reduced compared receptor gene polymorphism conditions privacy policy quadriceps muscle power isokinetic dynamometer test accepting optional cookies journal finder publish article log single twitch information alkaline phosphatase article cite article glerup privacy policy personal data muscle power books a muscle function optional cookies manage preferences women reduced compared check access instant access subscription content similar content osteomalacic myopathy data protection essential cookies cookies skip full normalization
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headline:Hypovitaminosis D Myopathy Without Biochemical Signs of Osteomalacic Bone Involvement
description: The aims of this study were to investigate myopathy in relation to vitamin D status, and to study the muscular effects of vitamin D treatment on vitamin D-deficient individuals. Further, hypovitaminosis D myopathy was investigated in relation to alkaline phosphatase (ALP), the most commonly used marker for hypovitaminosis D osteopathy. Eight patients with osteomalacia had an isokinetic dynamometer test of all major muscle groups before and after 3 months of vitamin D treatment. The most pronounced improvements in muscle power were seen in the weight-bearing antigravity muscles of the lower limbs. A cross-sectional study was performed among 55 vitamin D-deficient veiled Arab women living in Denmark and 22 Danish controls. An isometric dynamometer model was used for determination of quadriceps muscle power. Both maximal voluntary contraction (MVC) and electrically stimulated values (single twitch, maximal production rate (MPR), and maximal relaxation rate (MRR)) were determined. The women underwent high-dose vitamin D treatment and were retested after 3 and 6 months. Prior to vitamin D treatment all parameters of muscle function in the group of vitamin D-deficient Arab women were significantly reduced compared with Danish controls. MVC: 259.4 Β± 11.0 N (Newton) versus 392.6 Β± 11.4 N (P < 10β6), single twitch: 47.0 Β± 1.8 N versus 74.6 Β± 2.2 N (P < 10β5), MPR 8.9 Β± 0.3 N/10 ms versus 14.3 Β± 0.4 N/10 ms (P < 10β6), MRR 4.5 Β± 0.2 N/10 ms versus 6.2 Β± 0.2 N/10 ms (P < 10β6). Muscle function was affected to a similar degree in women with and without bone involvement (as indicated by elevated ALP). After 3 months of vitamin D treatment all muscle-related parameters improved significantly. After 6 months only MVC was reduced compared with Danish controls (320.7 Β± 14.3 N (P < 0.02)), whereas all other measurements were normalized. Hypovitaminosis D myopathy is a prominent symptom of vitamin D deficiency, and severely impaired muscle function may be present even before biochemical signs of bone disease develop. Full normalization of hypovitaminosis D myopathy demands high-dose vitamin D treatment for 6 months or more. Our findings indicate that serum levels of ALP cannot be used in the screening for hypovitaminosis D myopathy. Assessment of s-25OHD is the only reliable test.
datePublished:2014-03-22T00:00:00Z
dateModified:2014-03-22T00:00:00Z
pageStart:419
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sameAs:https://doi.org/10.1007/s002230010085
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Key words: Myopathy β Vitamin D β Osteomalaci β Alkaline phosphatase β Hypovitaminosis D myopathy.
Biochemistry
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Endocrinology
Orthopedics
Cell Biology
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headline:Hypovitaminosis D Myopathy Without Biochemical Signs of Osteomalacic Bone Involvement
description: The aims of this study were to investigate myopathy in relation to vitamin D status, and to study the muscular effects of vitamin D treatment on vitamin D-deficient individuals. Further, hypovitaminosis D myopathy was investigated in relation to alkaline phosphatase (ALP), the most commonly used marker for hypovitaminosis D osteopathy. Eight patients with osteomalacia had an isokinetic dynamometer test of all major muscle groups before and after 3 months of vitamin D treatment. The most pronounced improvements in muscle power were seen in the weight-bearing antigravity muscles of the lower limbs. A cross-sectional study was performed among 55 vitamin D-deficient veiled Arab women living in Denmark and 22 Danish controls. An isometric dynamometer model was used for determination of quadriceps muscle power. Both maximal voluntary contraction (MVC) and electrically stimulated values (single twitch, maximal production rate (MPR), and maximal relaxation rate (MRR)) were determined. The women underwent high-dose vitamin D treatment and were retested after 3 and 6 months. Prior to vitamin D treatment all parameters of muscle function in the group of vitamin D-deficient Arab women were significantly reduced compared with Danish controls. MVC: 259.4 Β± 11.0 N (Newton) versus 392.6 Β± 11.4 N (P < 10β6), single twitch: 47.0 Β± 1.8 N versus 74.6 Β± 2.2 N (P < 10β5), MPR 8.9 Β± 0.3 N/10 ms versus 14.3 Β± 0.4 N/10 ms (P < 10β6), MRR 4.5 Β± 0.2 N/10 ms versus 6.2 Β± 0.2 N/10 ms (P < 10β6). Muscle function was affected to a similar degree in women with and without bone involvement (as indicated by elevated ALP). After 3 months of vitamin D treatment all muscle-related parameters improved significantly. After 6 months only MVC was reduced compared with Danish controls (320.7 Β± 14.3 N (P < 0.02)), whereas all other measurements were normalized. Hypovitaminosis D myopathy is a prominent symptom of vitamin D deficiency, and severely impaired muscle function may be present even before biochemical signs of bone disease develop. Full normalization of hypovitaminosis D myopathy demands high-dose vitamin D treatment for 6 months or more. Our findings indicate that serum levels of ALP cannot be used in the screening for hypovitaminosis D myopathy. Assessment of s-25OHD is the only reliable test.
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Key words: Myopathy β Vitamin D β Osteomalaci β Alkaline phosphatase β Hypovitaminosis D myopathy.
Biochemistry
general
Endocrinology
Orthopedics
Cell Biology
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Analytics and Tracking {π}
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Libraries {π}
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