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Keywords {🔍}

article, google, scholar, pubmed, life, cas, quality, health, older, frailty, sarcopenia, sci, med, study, muscle, gerontol, ageing, clin, physical, biol, nutr, strength, university, research, disability, adults, geriatr, elderly, age, aging, res, review, women, qual, function, cooper, van, harris, care, newman, outcomes, goodpaster, clinical, osteoporosis, soc, visser, skeletal, department, lilly, servier,

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Questions {❓}

• Bernheim JL (1999) How to get serious answers to the serious question “How have you been?
• Bowling A, Stenner P (2011) Which measure of quality of life performs best in older age?
• Cawthon PM, Fox KM, Gandra SR, Delmonico MJ, Chiou CF, Anthony MS, Sewall A, Goodpaster B, Satterfield S, Cummings SR, Harris TB (2009) Do muscle mass, muscle density, strength, and physical function similarly influence risk of hospitalization in older adults?
• Gorby HE, Brownawell AM, Falk MC (2010) Do specific dietary constituents and supplements affect mental energy?
• Kerr A, Syddall HE, Cooper C, Turner GF, Briggs RS, Sayer AA (2006) Does admission grip strength predict length of stay in hospitalised older patients?
• Petermans J (2012) Pathological ageing: a myth or reality [in French]?
• Puts MT, Shekary N, Widdershoven G, Heldens J, Lips P, Deeg DJ (2007) What does quality of life mean to older frail and non-frail community-dwelling adults in the Netherlands?
• Sayer AA, Dennison EM, Syddall HE, Gilbody HJ, Phillips DI, Cooper C (2005) Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg?
• Sayer AA, Syddall HE, Martin HJ, Dennison EM, Roberts HC, Cooper C (2006) Is grip strength associated with health-related quality of life?

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         headline:Quality of Life in Sarcopenia and Frailty
         description:The reduced muscle mass and impaired muscle performance that define sarcopenia in older individuals are associated with increased risk of physical limitation and a variety of chronic diseases. They may also contribute to clinical frailty. A gradual erosion of quality of life (QoL) has been evidenced in these individuals, although much of this research has been done using generic QoL instruments, particularly the SF-36, which may not be ideal in older populations with significant comorbidities. This review and report of an expert meeting presents the current definitions of these geriatric syndromes (sarcopenia and frailty). It then briefly summarizes QoL concepts and specificities in older populations and examines the relevant domains of QoL and what is known concerning QoL decline with these conditions. It calls for a clearer definition of the construct of disability, argues that a disease-specific QoL instrument for sarcopenia/frailty would be an asset for future research, and discusses whether there are available and validated components that could be used to this end and whether the psychometric properties of these instruments are sufficiently tested. It calls also for an approach using utility weighting to provide some cost estimates and suggests that a time trade-off study could be appropriate.
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            Cell Biology
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      headline:Quality of Life in Sarcopenia and Frailty
      description:The reduced muscle mass and impaired muscle performance that define sarcopenia in older individuals are associated with increased risk of physical limitation and a variety of chronic diseases. They may also contribute to clinical frailty. A gradual erosion of quality of life (QoL) has been evidenced in these individuals, although much of this research has been done using generic QoL instruments, particularly the SF-36, which may not be ideal in older populations with significant comorbidities. This review and report of an expert meeting presents the current definitions of these geriatric syndromes (sarcopenia and frailty). It then briefly summarizes QoL concepts and specificities in older populations and examines the relevant domains of QoL and what is known concerning QoL decline with these conditions. It calls for a clearer definition of the construct of disability, argues that a disease-specific QoL instrument for sarcopenia/frailty would be an asset for future research, and discusses whether there are available and validated components that could be used to this end and whether the psychometric properties of these instruments are sufficiently tested. It calls also for an approach using utility weighting to provide some cost estimates and suggests that a time trade-off study could be appropriate.
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         Aging
         Muscle weakness
         Quality of life
         Malnutrition
         Biochemistry
         general
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         Orthopedics
         Cell Biology
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            address:
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      name:Kieran Reid
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            address:
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            address:
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            name:Institut de Recherches Internationales Servier
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               name:Institut de Recherches Internationales Servier, Suresnes, France
               type:PostalAddress
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      affiliation:
            name:VU University
            address:
               name:Department of Health Sciences, VU University, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:VU University Medical Center
            address:
               name:Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Olivier Bruyère
      affiliation:
            name:University of Liege
            address:
               name:Department of Public Health, Epidemiology and Health Economics, University of Liege, Liege, Belgium
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Service of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
      name:Department of Public Health, Epidemiology and Health Economics, University of Liege, Liege, Belgium
      name:INSERM Research Unit 1048, Faculty of Medicine, University of Toulouse and CHU of Toulouse, Toulouse, France
      name:Gerontology and Frailty in Ageing Research Department, Vrije Universiteit, Brussels, Belgium
      name:Department of Public Health, Epidemiology and Health Economics, University of Liege, Liege, Belgium
      name:Centre on Aging and Mobility, University of Zurich, Zurich, Switzerland
      name:Service of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
      name:Division of Geriatric Medicine & Center for Metabolic Bone Diseases, Department of Internal Medicine, Leuven University Hospital, Leuven, Belgium
      name:Department of Internal Medicine, University of Florence, Florence, Italy
      name:Amgen Inc., Thousand Oaks, USA
      name:MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
      name:Division of Endocrinology, Mount Sinai School of Medicine, New York, USA
      name:Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, USA
      name:Department of Medicine, University of Pittsburgh, Pittsburgh, USA
      name:WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK
      name:Department of Endocrinology, Ghent University Hospital, Gent, Belgium
      name:Austrian Agency for Health and Food Safety, Vienna, Austria
      name:Department of Geriatrics, Hospital San Juan de Dios, Pamplona, Spain
      name:Department of Geriatrics, University Hospital of Getafe, Madrid, Spain
      name:Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, USA
      name:Bone and Joint Research Group, Institute of Developmental Sciences, University of Southampton Medical School, Southampton, UK
      name:Service of Geriatrics, CHU of Liege, Liege, Belgium
      name:WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK
      name:Gérontopôle of Toulouse, University of Toulouse III, CHU Purpan, Toulouse, France
      name:MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
      name:Institut de Recherches Internationales Servier, Suresnes, France
      name:Department of Health Sciences, VU University, Amsterdam, The Netherlands
      name:Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
      name:Department of Public Health, Epidemiology and Health Economics, University of Liege, Liege, Belgium
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