We are analyzing https://link.springer.com/article/10.1007/s00221-022-06331-9.

Title:
Erythropoietin regulates signaling pathways associated with neuroprotective events | Experimental Brain Research
Description:
Erythropoietin is a cytokine that binds to the Erythropoietin receptor and regulates the formation of erythroid cells during erythropoiesis in the bone marrow. However, many other organs and tissues express Erythropoietin and its receptor, such as the Nervous System, which principally regulates tissue protection. In the Central Nervous System, Erythropoietin is principally expressed by astrocytes, while neurons mainly express Erythropoietin receptors. Moreover, Erythropoietin acts as a pleiotropic molecule with neuroprotective effects, and its mechanisms of signal transduction pathways are defined, and there is a growing interest in its therapeutic potential. This review focuses on the role of Erythropoietin and its relationship with HIF1, PI3/Akt, GSK3B, JAK/STAT, and MAPKs signaling pathways that leads to cell survival after injury in the Central Nervous System. Knowledge of these signaling systems comprehensively could better guide EPO treatment to restoring different SNC alterations mediated by different insults.
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Keywords {🔍}

article, pubmed, google, scholar, cas, erythropoietin, central, cell, res, brain, pathway, zhang, signaling, apoptosis, pathways, receptor, cells, httpsdoiorg, httpsdoiorgs, wang, neurons, epo, chen, neuroprotective, potential, injury, neurosci, effects, neuroprotection, neuronal, med, rat, research, nervous, factor, human, cancer, rats, yang, mol, epub, content, castañedaarellano, system, signal, exp, activation, lee, spinal, privacy,

Topics {✒️}

/jak2/stat5/pi3k/akt/gsk-3β pathway 1-methyl-4-phenylpyridinium ion-induced apoptosis castañeda-arellano rolando jak2/stat3/pi3k/akt/mtor pathway nf-kappab signalling cascades pi3k-akt-mtor signaling pathway hypoxia-inducible factor-1α month download article/chapter human ischemic/hypoxic brain central nervous system hypoxia-inducible factor 1 erythropoietin-modulated calcium influx erk1/2-nrf2/bach1 signal pathway pi3k/akt signaling pathway light-induced retinal degeneration transcription factor nf-kappab castañeda-arellano hypoxic retina protects nf-kappab-regulated inhibitor erythropoietin-derived peptide mk pi3k/akt pathway activation myd88/erk/nfkb pathways kainic acid-induced epilepsy rivera-cervantes mc pro-inflammatory cytokines release writing—original draft preparation gsk-3 beta pathway erythropoietin-mediated neuroprotection castañeda-cabral jl final manuscript approval article sergio excess bcl-xl increases mapks signaling pathways hematopoietic signaling pathways full article pdf concomitantly pi3-kinase activation signaling systems comprehensively neuronal damage induced express erythropoietin receptors cornelio-martínez akt/pkb signaling jak2/stat3 pathway de santis mc universidad de guadalajara acute anoxic injury crucial transcription factor global cerebral ischemia phosphatidylinositol 3-kinase pathway nervous system heme-mediated inhibition

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      headline:Erythropoietin regulates signaling pathways associated with neuroprotective events
      description:Erythropoietin is a cytokine that binds to the Erythropoietin receptor and regulates the formation of erythroid cells during erythropoiesis in the bone marrow. However, many other organs and tissues express Erythropoietin and its receptor, such as the Nervous System, which principally regulates tissue protection. In the Central Nervous System, Erythropoietin is principally expressed by astrocytes, while neurons mainly express Erythropoietin receptors. Moreover, Erythropoietin acts as a pleiotropic molecule with neuroprotective effects, and its mechanisms of signal transduction pathways are defined, and there is a growing interest in its therapeutic potential. This review focuses on the role of Erythropoietin and its relationship with HIF1, PI3/Akt, GSK3B, JAK/STAT, and MAPKs signaling pathways that leads to cell survival after injury in the Central Nervous System. Knowledge of these signaling systems comprehensively could better guide EPO treatment to restoring different SNC alterations mediated by different insults.
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