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n-methyl-d-aspartate receptor hypofunction tumor promoter 12-o-tetradecanoylphorbol-13-acetate p70s6k-s6/eif4b signal pathways month download article/chapter nmda receptor blockade valproate prevents mk801-induced mk-801-induced neuronal damages nmda receptor-dependent function mk-801-induced ppi deficits 11-oxo-mogrol reversed inactivation ephrin-b3 reverse signaling mechanism-related drug discoveries mk801-induced neuronal damages diet-induced obese mice alloxan-induced diabetic mice mk-801-induced mouse model enhances phencyclidine-induced hyperlocomotion parvalbumin-immunoreactive gabaergic neurons nmda receptor antagonist long-term behavioural effects shanghai key laboratory akt1/gsk3beta signaling pathway lc-q-tof/ms h2o2 induced apoptosis nmda antagonist neurotoxicity full article pdf nmda receptor antagonists article psychopharmacology aims inhibiting cell apoptosis article ju privacy choices/manage cookies neuronal damages elicited glutamatergic animal models nmda-dependent modulation human intestinal microbiota human intestinal bacteria aripiprazole-treated mice spent pcp/nmda model metabolite 11-oxo-mogrol social deficits induced rescues nerve cells pi3k signaling pathway cellular damages induced medial prefrontal cortex enhances notch signaling mengyue wang designed oxidative stress pathways camk2αand calbindin expression mk-801 reduces density guangzhou medical university

Questions {❓}

• Javitt DC, Zukin SR, Heresco-Levy U, Umbricht D (2012) Has an angel shown the way?
• Zhang C, Mao Y, Song L (2018) Precise treatments for schizophrenia: where is the way forward?

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         description:Animal models, notably with non-competitive NMDA receptor antagonist MK801, are commonly used to investigate the mechanisms of schizophrenia and to pursue its mechanism-related drug discoveries. In the current study, we have extensively examined the protective effects of MogrosideV (MogV), a plant-derived three terpene glucoside known to exhibit anti-oxidative and anti-inflammatory activities. Here, we investigated its protective effects against neuronal damages elicited by MK-801 treatment. Our behavioral experimental results showed that MK-801-induced PPI deficits and social withdrawal were prevented by MogV treatment. Moreover, the cellular and neurochemical responses of MK-801 in medial prefrontal cortical cortex (mPFC) were also ameliorated by MogV treatment. Also, profiling metabolites assay through artificial intestinal microbiota was performed to identify bioactive components of MogV. An in vitro study of primary neuronal culture demonstrated that MogV and its metabolite 11-oxo-mogrol treatment prevented the MK-801-induced neuronal damages through the mechanisms of promoting neurite outgrowth, inhibiting cell apoptosis, and [Ca2+]i release. Additionally, 11-oxo-mogrol reversed inactivation of phosphorylation levels of AKT and mTOR induced by MK801. These results suggest therapeutic potential of MogV for schizophrenia.
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      name:Ying Cheng
      affiliation:
            name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University
            address:
               name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Beibei Yang
      affiliation:
            name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University
            address:
               name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Lanting Huang
      affiliation:
            name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University
            address:
               name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Qiong Zhou
      affiliation:
            name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University
            address:
               name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Cuizhen Zhu
      affiliation:
            name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University
            address:
               name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
               type:PostalAddress
            type:Organization
            name:Anhui Mental Health Center
            address:
               name:Anhui Mental Health Center, Hefei, China
               type:PostalAddress
            type:Organization
      name:Xiaobo Li
      affiliation:
            name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University
            address:
               name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Mengyue Wang
      affiliation:
            name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University
            address:
               name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jinghong Chen
      affiliation:
            name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University
            address:
               name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
               type:PostalAddress
            type:Organization
            name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
            address:
               name:Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
      name:Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
      name:The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
      name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
      name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
      name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
      name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
      name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
      name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
      name:Anhui Mental Health Center, Hefei, China
      name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
      name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
      name:Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
      name:Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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