We are analyzing https://link.springer.com/article/10.1007/s00213-019-05200-8.

Title:
Inflammation in cancer and depression: a starring role for the kynurenine pathway | Psychopharmacology
Description:
Depression is a common comorbidity in cancer cases, but this is not only due to the emotional distress of having a life-threatening disease. A common biological mechanism, involving a dysregulated immune system, seems to underpin this comorbidity. In particular, the activation of the kynurenine pathway of tryptophan degradation due to inflammation may play a key role in the development and persistence of both diseases. As a consequence, targeting enzymes involved in this pathway offers a unique opportunity to develop new strategies to treat cancer and depression at once. In this work, we provide a systematic review of the evidence up to date on the kynurenine pathway role in linking depression and cancer and on clinical implications of this evidence. In particular, complications due to chemotherapy are discussed, as well as the potential antidepressant efficacy of novel immunotherapies for cancer.
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Keywords {🔍}

cancer, pubmed, depression, kynurenine, article, google, scholar, pathway, cas, ido, patients, tryptophan, symptoms, central, depressive, immune, activation, clinical, treatment, inflammation, brain, study, levels, role, studies, dioxygenase, ratio, activity, development, inhibitors, related, tumor, evidence, breast, inflammatory, metabolism, indoleamine, found, cell, res, research, increased, effects, ifnalpha, fatigue, major, depressed, therapy, review, chemotherapy,

Topics {✒️}

alpha-amino-beta-carboxymuconate-epsilon-semialdehyde colleagues utilized 11c-alpha-methyl-l-tryptophan n-methyl-d-aspartate pd1 11c-alpha-methyl-l-tryptophan bdi ido1-mediated t-cell regulation article download pdf observer-based rating scales increased c-reactive protein verdonck-de leeuw im including 1-methyl-l-tryptophan single-item distress screening cell–dependent autoimmune responses mini-international neuropsychiatric interview tumor-draining lymph nodes cell–mediated autoantibody production met/methionine sulfoxide ratios decreasing pro-inflammatory cytokines central immune system interferon-alpha-induced inflammation received research funding oxidative stress-related signatures fibroblast-mediated cancer progression van gool ar 1-methyl-d-tryptophan prevalent anti-tumoral effect dsm-iv-tr criteria ido1-selective enzyme inhibitor il-1β-induced reduction cancer-induced qol deterioration article sforzini potential rate-limiting enzyme nicotinamide adenine dinucleotide profiles registry pro-inflammatory immune activity increased quin/kyna ratios potential pro-inflammatory effect early-stage breast cancer symptom check list-90 ten hoor ka immune-mediated tryptophan degradation immune-mediated ido activation shown anti-inflammatory effects privacy choices/manage cookies pro-tumorigenic factor tumor-bearing mice mdd medication–free patients intervention ifn-alpha treatment cell surface protein antidepressant-free patients compared maria antonietta nettis

Questions {❓}

Balon R (2006) Mood, anxiety, and physical illness: body and mind, or mind and body?
Baumeister D, Ciufolini S, Mondelli V (2016) Effects of psychotropic drugs on inflammation: consequence or mediator of therapeutic effects in psychiatric treatment?
Is kynurenine pathway the potential link between depression and cancer?
Kasparian NA (2013) Psychological stress and melanoma: are we meeting our patients’ psychological needs?
Quak J, Doornbos B, Roest AM, Duivis HE, Vogelzangs N, Nolen WA, Penninx BWJH, Kema IP, De Jonge P (2014) Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?
Sperner-Unterweger B, Kohl C, Fuchs D (2014) Immune changes and neurotransmitters: Possible interactions in depression?

Schema {🗺️}

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         description:Depression is a common comorbidity in cancer cases, but this is not only due to the emotional distress of having a life-threatening disease. A common biological mechanism, involving a dysregulated immune system, seems to underpin this comorbidity. In particular, the activation of the kynurenine pathway of tryptophan degradation due to inflammation may play a key role in the development and persistence of both diseases. As a consequence, targeting enzymes involved in this pathway offers a unique opportunity to develop new strategies to treat cancer and depression at once. In this work, we provide a systematic review of the evidence up to date on the kynurenine pathway role in linking depression and cancer and on clinical implications of this evidence. In particular, complications due to chemotherapy are discussed, as well as the potential antidepressant efficacy of novel immunotherapies for cancer.
         datePublished:2019-02-26T00:00:00Z
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      headline:Inflammation in cancer and depression: a starring role for the kynurenine pathway
      description:Depression is a common comorbidity in cancer cases, but this is not only due to the emotional distress of having a life-threatening disease. A common biological mechanism, involving a dysregulated immune system, seems to underpin this comorbidity. In particular, the activation of the kynurenine pathway of tryptophan degradation due to inflammation may play a key role in the development and persistence of both diseases. As a consequence, targeting enzymes involved in this pathway offers a unique opportunity to develop new strategies to treat cancer and depression at once. In this work, we provide a systematic review of the evidence up to date on the kynurenine pathway role in linking depression and cancer and on clinical implications of this evidence. In particular, complications due to chemotherapy are discussed, as well as the potential antidepressant efficacy of novel immunotherapies for cancer.
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               type:PostalAddress
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      name:Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King’s College London, London, UK
      name:National Institute for Health and Research Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London, London, UK
      name:Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King’s College London, London, UK
      name:National Institute for Health and Research Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London, London, UK
      name:Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King’s College London, London, UK
      name:National Institute for Health and Research Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London, London, UK

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