We are analyzing https://link.springer.com/article/10.1007/s00213-007-0729-8.

Title:
Prenatal exposure to an NMDA receptor antagonist, MK-801 reduces density of parvalbumin-immunoreactive GABAergic neurons in the medial prefrontal cortex and enhances phencyclidine-induced hyperlocomotion but not behavioral sensitization to methamphetamine in postpubertal rats | Psychopharmacology
Description:
Rationale Neurodevelopmental deficits of parvalbumin-immunoreactive γ-aminobutyric acid (GABA)ergic interneurons in prefrontal cortex have been reported in schizophrenia. Glutamate influences the proliferation of this type of interneuron by an N-methyl-d-aspartate (NMDA)-receptor-mediated mechanism. The present study hypothesized that prenatal blockade of NMDA receptors would disrupt GABAergic neurodevelopment, resulting in differences in effects on behavioral responses to a noncompetitive NMDA antagonist, phencyclidine (PCP), and a dopamine releaser, methamphetamine (METH). Methods GABAergic neurons were immunohistochemically stained with parvalbumin antibody. Psychostimulant-induced hyperlocomotion was measured using an infrared sensor. Results Prenatal exposure (E15–E18) to the NMDA receptor antagonist MK-801 reduced the density of parvalbumin-immunoreactive neurons in rat medial prefrontal cortex on postnatal day 63 (P63) and enhanced PCP-induced hyperlocomotion but not the acute effects of METH on P63 or the development of behavioral sensitization. Prenatal exposure to MK-801 reduced the number of parvalbumin-immunoreactive neurons even on postnatal day 35 (P35) and did not enhance PCP-induced hyperlocomotion, the acute effects of METH on P35, or the development of behavioral sensitization to METH. Conclusions These findings suggest that prenatal blockade of NMDA receptors disrupts GABAergic neurodevelopment in medial prefrontal cortex, and that this disruption of GABAergic development may be related to the enhancement of the locomotion-inducing effect of PCP in postpubertal but not juvenile offspring. GABAergic deficit is unrelated to the effects of METH. This GABAergic neurodevelopmental disruption and the enhanced PCP-induced hyperlocomotion in adult offspring prenatally exposed to MK-801 may prove useful as a new model of the neurodevelopmental process of pathogenesis of treatment-resistant schizophrenia via an NMDA-receptor-mediated hypoglutamatergic mechanism.
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Keywords {🔍}

google, scholar, article, pubmed, cas, schizophrenia, cortex, receptor, nmda, gabaergic, psychiatry, prefrontal, psychopharmacology, neurons, rat, prenatal, behavioral, effects, res, brain, phencyclidineinduced, hyperlocomotion, antagonist, parvalbuminimmunoreactive, receptors, parvalbumin, biol, exposure, sensitization, rats, phencyclidine, meth, development, neurosci, privacy, cookies, content, research, medial, abekawa, interneurons, glutamate, study, blockade, pcp, dopamine, acute, adult, access, cortical,

Topics {✒️}

n-methyl-d-aspartate receptors n-methyl-d-aspartate parvalbumin-immunoreactive γ-aminobutyric acid nmda-receptor-mediated hypoglutamatergic mechanism month download article/chapter ethanol-induced apoptosis neurodegeneration shin nakagawa & tsukasa koyama γ-aminobutyric acid neurotransmission audiogenic seizure-prone balb/ placebo-controlled pilot study enhanced pcp-induced hyperlocomotion enhance pcp-induced hyperlocomotion mammalian alpha-lineage parvalbumin enhances phencyclidine-induced hyperlocomotion parvalbumin-immunoreactive gabaergic neurons gabaa receptor binding phencyclidine-induced dopamine release nmda receptor antagonist nmda receptor antagonists full article pdf noncompetitive nmda antagonist calbindin d-28k article psychopharmacology aims receptor-mediated mechanism mk-801 reduces density privacy choices/manage cookies prenatal exposure phencyclidine-induced hyperactivity gamma oscillations meyer wj iii parvalbumin-immunoreactive neurons ketamine stimulates psychosis psychostimulant-induced hyperlocomotion phencyclidine-induced hyperlocomotion striatal d2 receptor paranoid psychotic state disrupt gabaergic neurodevelopment gabaergic neurodevelopmental disruption nmda receptor blockade article abekawa neuronal migration glutamate receptor dysfunction phencyclidine-induced activation refined crystal structure chronic pcp model clinical research studies α1 adrenaline receptors cortical inhibitory neurons medial prefrontal cortex induced behavioral stimulation

Questions {❓}

Farber NB, Wozniak DF, Price MT, Labruyere J, Huss J, St Peter H, Olney JW (1995) Age-specific neurotoxicity in the rat associated with NMDA receptor blockade: potential relevance to schizophrenia?

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