We are analyzing https://link.springer.com/article/10.1007/s00210-025-03883-9.

Title:
Enhancer zeste homolog 2 (EZH2) targeting by small interfering RNA (siRNA); recent advances and prospect | Naunyn-Schmiedeberg's Archives of Pharmacology
Description:
Enhancer of zeste homolog 2 (EZH2) serves as the enzymatic catalytic subunit of the polycomb repressive complex 2 (PRC2), which is capable of modifying the expression of downstream target genes through the trimethylation of Lys-27 on histone 3 (H3K27me3). In addition to its role in H3K27me3 modification, EZH2 may influence gene expression through alternative mechanisms. The involvement of EZH2 in cellular processes such as proliferation, apoptosis, and senescence has been established. Its significant contributions to the pathophysiology of cancer have garnered considerable attention. Consequently, pursuing EZH2 as a target for cancer therapy has become a prominent area of research, leading to the development of various EZH2 inhibitors. A growing number of efforts are being made to investigate the possible application of small interfering RNA (siRNA) in medical applications after the practical application of this technique to decrease gene expression in various research models. Pharmacological inhibition of EZH2 induces apoptosis in cancer cells, while siRNA-mediated downregulation of EZH2 suppresses cancer cell growth. The cell cycle is modulated by siRNA-induced suppression of EZH2, yet its precise cause is unclear. Furthermore, inadequate research has been done on the signaling route affecting cancer cells’ cell cycle following EZH2 suppression with siRNA. Investigating the molecular basis of EZH2 siRNA’s anticancer activity will aid in developing fresh methods for identifying, managing, and preventing cancer.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

pubmed, google, scholar, article, cas, ezh, cancer, central, cell, wang, zhang, cells, liu, chen, expression, resistance, yang, tumor, res, zhou, carcinoma, sun, mol, zhao, regulates, oncol, promotes, targeting, epigenetic, breast, huang, lee, zeste, polycomb, inhibition, nat, lin, kim, metastasis, cisplatin, enhancer, homolog, histone, regulation, sci, cai, biol, cao, lung, rna,

Topics {✒️}

chemotherapy-elicited exosomal mir-378a-3p dsrna–sting–interferon stress axis phospho-δnp63α/microrna feedback regulation ezh2–erα–greb1 transcriptional axis month download article/chapter chou-yi hsu ews-fli1-mediated enhancer activation microrna-153-3p increases autophagy mir-181b/hk2 axis inhibits cell growth polycomb-group gene ezh2 swi/snf complex deregulation ezh2-mediated epigenetic silencing muscle-invasive bladder cancer microrna-506-3p increases ezh2 promotes migration targeting ezh2/β-catenin gene set-based identification pre-malignant lymphoma niche prc2-mediated epigenetic suppression histone methylation-dependent pathways cd8-positive t-lymphocytes kras-driven lung adenocarcinoma integrating phosphorylation-dependent activation activating pi3k/akt pathway macrophage polarization contributes mir-144/451a cluster contributes small-cell lung tumor ews-fli1 increases transcription characterize cancer-dependent exhaustion regulating timp2-mmp-2/-9 pathway article naunyn-schmiedeberg' e-cadherin expression inflammation-induced repression jak2/stat3 signaling pathway ezh2 decreases growth mutant ezh2 induces article hsu full article pdf ezh2 induces apoptosis mir-101/ezh2 axis cell-surface annexin a2 plasma cell polarization mir-29/mir-30 targets loxl4 natural killer cells histone methyltransferase ezh2 ezh2 histone methyltransferase acute viral infection cell differentiation–regulating genes rna interference reverses

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Enhancer zeste homolog 2 (EZH2) targeting by small interfering RNA (siRNA); recent advances and prospect
         description:Enhancer of zeste homolog 2 (EZH2) serves as the enzymatic catalytic subunit of the polycomb repressive complex 2 (PRC2), which is capable of modifying the expression of downstream target genes through the trimethylation of Lys-27 on histone 3 (H3K27me3). In addition to its role in H3K27me3 modification, EZH2 may influence gene expression through alternative mechanisms. The involvement of EZH2 in cellular processes such as proliferation, apoptosis, and senescence has been established. Its significant contributions to the pathophysiology of cancer have garnered considerable attention. Consequently, pursuing EZH2 as a target for cancer therapy has become a prominent area of research, leading to the development of various EZH2 inhibitors. A growing number of efforts are being made to investigate the possible application of small interfering RNA (siRNA) in medical applications after the practical application of this technique to decrease gene expression in various research models. Pharmacological inhibition of EZH2 induces apoptosis in cancer cells, while siRNA-mediated downregulation of EZH2 suppresses cancer cell growth. The cell cycle is modulated by siRNA-induced suppression of EZH2, yet its precise cause is unclear. Furthermore, inadequate research has been done on the signaling route affecting cancer cells’ cell cycle following EZH2 suppression with siRNA. Investigating the molecular basis of EZH2 siRNA’s anticancer activity will aid in developing fresh methods for identifying, managing, and preventing cancer.
         datePublished:2025-02-17T00:00:00Z
         dateModified:2025-02-17T00:00:00Z
         pageStart:1
         pageEnd:22
         sameAs:https://doi.org/10.1007/s00210-025-03883-9
         keywords:
            Cancer
            EZH2
            SiRNA
            Migration
            Growth
            Drug resistance
            Pharmacology/Toxicology
            Neurosciences
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-025-03883-9/MediaObjects/210_2025_3883_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-025-03883-9/MediaObjects/210_2025_3883_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-025-03883-9/MediaObjects/210_2025_3883_Fig3_HTML.jpg
         isPartOf:
            name:Naunyn-Schmiedeberg's Archives of Pharmacology
            issn:
               1432-1912
               0028-1298
            type:
               Periodical
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Chou-Yi Hsu
               affiliation:
                     name:Arizona State University
                     address:
                        name:Thunderbird School of Global Management, Arizona State University, Tempe Campus, Phoenix, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Abdulsalam Najm Mohammed
               affiliation:
                     name:University of Al-Maarif
                     address:
                        name:Department of Medical Laboratory Techniques, College of Health and Technology, University of Al-Maarif, Ramadi, Iraq
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Ahmed Hjazi
               affiliation:
                     name:Prince Sattam Bin Abdulaziz University
                     address:
                        name:Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Subasini Uthirapathy
               affiliation:
                     name:Tishk International University
                     address:
                        name:Pharmacy Department, Tishk International University, Erbil, Iraq
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jyothi S. Renuka
               affiliation:
                     name:JAIN (Deemed to Be University)
                     address:
                        name:Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to Be University), Bangalore, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Abhayveer Singh
               affiliation:
                     name:Chitkara University Institute of Engineering and Technology, Chitkara University
                     address:
                        name:Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Thyagarajan
               affiliation:
                     name:Sathyabama Institute of Science and Technology
                     address:
                        name:Department of Biotechnology, Sathyabama Institute of Science and Technology, Chennai, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Subhashree Ray
               affiliation:
                     name:IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to Be University)
                     address:
                        name:Department of Biochemistry, IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to Be University), Bhubaneswar, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hanen Mahmod Hulail
               affiliation:
                     name:AL-Nisour University College
                     address:
                        name:Hanen Mahmod Hulail/ Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Enhancer zeste homolog 2 (EZH2) targeting by small interfering RNA (siRNA); recent advances and prospect
      description:Enhancer of zeste homolog 2 (EZH2) serves as the enzymatic catalytic subunit of the polycomb repressive complex 2 (PRC2), which is capable of modifying the expression of downstream target genes through the trimethylation of Lys-27 on histone 3 (H3K27me3). In addition to its role in H3K27me3 modification, EZH2 may influence gene expression through alternative mechanisms. The involvement of EZH2 in cellular processes such as proliferation, apoptosis, and senescence has been established. Its significant contributions to the pathophysiology of cancer have garnered considerable attention. Consequently, pursuing EZH2 as a target for cancer therapy has become a prominent area of research, leading to the development of various EZH2 inhibitors. A growing number of efforts are being made to investigate the possible application of small interfering RNA (siRNA) in medical applications after the practical application of this technique to decrease gene expression in various research models. Pharmacological inhibition of EZH2 induces apoptosis in cancer cells, while siRNA-mediated downregulation of EZH2 suppresses cancer cell growth. The cell cycle is modulated by siRNA-induced suppression of EZH2, yet its precise cause is unclear. Furthermore, inadequate research has been done on the signaling route affecting cancer cells’ cell cycle following EZH2 suppression with siRNA. Investigating the molecular basis of EZH2 siRNA’s anticancer activity will aid in developing fresh methods for identifying, managing, and preventing cancer.
      datePublished:2025-02-17T00:00:00Z
      dateModified:2025-02-17T00:00:00Z
      pageStart:1
      pageEnd:22
      sameAs:https://doi.org/10.1007/s00210-025-03883-9
      keywords:
         Cancer
         EZH2
         SiRNA
         Migration
         Growth
         Drug resistance
         Pharmacology/Toxicology
         Neurosciences
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-025-03883-9/MediaObjects/210_2025_3883_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-025-03883-9/MediaObjects/210_2025_3883_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-025-03883-9/MediaObjects/210_2025_3883_Fig3_HTML.jpg
      isPartOf:
         name:Naunyn-Schmiedeberg's Archives of Pharmacology
         issn:
            1432-1912
            0028-1298
         type:
            Periodical
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Chou-Yi Hsu
            affiliation:
                  name:Arizona State University
                  address:
                     name:Thunderbird School of Global Management, Arizona State University, Tempe Campus, Phoenix, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Abdulsalam Najm Mohammed
            affiliation:
                  name:University of Al-Maarif
                  address:
                     name:Department of Medical Laboratory Techniques, College of Health and Technology, University of Al-Maarif, Ramadi, Iraq
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Ahmed Hjazi
            affiliation:
                  name:Prince Sattam Bin Abdulaziz University
                  address:
                     name:Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Subasini Uthirapathy
            affiliation:
                  name:Tishk International University
                  address:
                     name:Pharmacy Department, Tishk International University, Erbil, Iraq
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jyothi S. Renuka
            affiliation:
                  name:JAIN (Deemed to Be University)
                  address:
                     name:Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to Be University), Bangalore, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Abhayveer Singh
            affiliation:
                  name:Chitkara University Institute of Engineering and Technology, Chitkara University
                  address:
                     name:Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thyagarajan
            affiliation:
                  name:Sathyabama Institute of Science and Technology
                  address:
                     name:Department of Biotechnology, Sathyabama Institute of Science and Technology, Chennai, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Subhashree Ray
            affiliation:
                  name:IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to Be University)
                  address:
                     name:Department of Biochemistry, IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to Be University), Bhubaneswar, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hanen Mahmod Hulail
            affiliation:
                  name:AL-Nisour University College
                  address:
                     name:Hanen Mahmod Hulail/ Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical"]:
      name:Naunyn-Schmiedeberg's Archives of Pharmacology
      issn:
         1432-1912
         0028-1298
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Arizona State University
      address:
         name:Thunderbird School of Global Management, Arizona State University, Tempe Campus, Phoenix, USA
         type:PostalAddress
      name:University of Al-Maarif
      address:
         name:Department of Medical Laboratory Techniques, College of Health and Technology, University of Al-Maarif, Ramadi, Iraq
         type:PostalAddress
      name:Prince Sattam Bin Abdulaziz University
      address:
         name:Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
         type:PostalAddress
      name:Tishk International University
      address:
         name:Pharmacy Department, Tishk International University, Erbil, Iraq
         type:PostalAddress
      name:JAIN (Deemed to Be University)
      address:
         name:Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to Be University), Bangalore, India
         type:PostalAddress
      name:Chitkara University Institute of Engineering and Technology, Chitkara University
      address:
         name:Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, India
         type:PostalAddress
      name:Sathyabama Institute of Science and Technology
      address:
         name:Department of Biotechnology, Sathyabama Institute of Science and Technology, Chennai, India
         type:PostalAddress
      name:IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to Be University)
      address:
         name:Department of Biochemistry, IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to Be University), Bhubaneswar, India
         type:PostalAddress
      name:AL-Nisour University College
      address:
         name:Hanen Mahmod Hulail/ Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Chou-Yi Hsu
      affiliation:
            name:Arizona State University
            address:
               name:Thunderbird School of Global Management, Arizona State University, Tempe Campus, Phoenix, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Abdulsalam Najm Mohammed
      affiliation:
            name:University of Al-Maarif
            address:
               name:Department of Medical Laboratory Techniques, College of Health and Technology, University of Al-Maarif, Ramadi, Iraq
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Ahmed Hjazi
      affiliation:
            name:Prince Sattam Bin Abdulaziz University
            address:
               name:Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
               type:PostalAddress
            type:Organization
      name:Subasini Uthirapathy
      affiliation:
            name:Tishk International University
            address:
               name:Pharmacy Department, Tishk International University, Erbil, Iraq
               type:PostalAddress
            type:Organization
      name:Jyothi S. Renuka
      affiliation:
            name:JAIN (Deemed to Be University)
            address:
               name:Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to Be University), Bangalore, India
               type:PostalAddress
            type:Organization
      name:Abhayveer Singh
      affiliation:
            name:Chitkara University Institute of Engineering and Technology, Chitkara University
            address:
               name:Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, India
               type:PostalAddress
            type:Organization
      name:Thyagarajan
      affiliation:
            name:Sathyabama Institute of Science and Technology
            address:
               name:Department of Biotechnology, Sathyabama Institute of Science and Technology, Chennai, India
               type:PostalAddress
            type:Organization
      name:Subhashree Ray
      affiliation:
            name:IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to Be University)
            address:
               name:Department of Biochemistry, IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to Be University), Bhubaneswar, India
               type:PostalAddress
            type:Organization
      name:Hanen Mahmod Hulail
      affiliation:
            name:AL-Nisour University College
            address:
               name:Hanen Mahmod Hulail/ Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Thunderbird School of Global Management, Arizona State University, Tempe Campus, Phoenix, USA
      name:Department of Medical Laboratory Techniques, College of Health and Technology, University of Al-Maarif, Ramadi, Iraq
      name:Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
      name:Pharmacy Department, Tishk International University, Erbil, Iraq
      name:Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to Be University), Bangalore, India
      name:Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, India
      name:Department of Biotechnology, Sathyabama Institute of Science and Technology, Chennai, India
      name:Department of Biochemistry, IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to Be University), Bhubaneswar, India
      name:Hanen Mahmod Hulail/ Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(655)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

6.25s.

LINK . SPRINGER . COM {}