We are analyzing https://link.springer.com/article/10.1007/s00210-024-03518-5.

Title:
The effect of adipose-derived mesenchymal stem cells against high fructose diet induced liver dysfunction and dysbiosis | Naunyn-Schmiedeberg's Archives of Pharmacology
Description:
High fructose diet (HFrD) has been approved to be involved in the pathogenesis of insulin resistance. Mesenchymal stem cells have a vital role in the treatment of various diseases including metabolic disturbances. We investigated the effect of Adipose-derived mesenchymal stem cells (ADMSCs) against HFrD-induced metabolic disorders and the molecular mechanisms for this effect. Rats were divided into 3 groups; control, HFrD, and combined HFrD with ADMSCs. We assessed liver functions, gut microbiota activity, oxidative stress, adiponectin, and IL10 levels. Also, we measured SREBP-1, IRS-1 expression using Western blot, and Malat1 expression using rt-PCR. ADMSCs antagonized metabolic abnormalities induced by HFrD in the form of improvement of liver functions and alleviation of oxidative stress. In addition, ADMSCs ameliorated gut microbiota activity besides the elevation of adiponectin and IL10 levels. ADMSCs attenuated insulin resistance through upregulation of IRS1 and downregulation of SREBP-1 and Malat1. ADMSCs can protect against HFrD-induced metabolic hazards.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

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Topics {✒️}

high-fat/high-fructose diet-fed rats short-chain fatty acids high-fructose diet-induced nash high-fat high-fructose diet enzyme-linked immuno-sorbent assay adipose-derived stem cells short-chain fatty acid article download pdf enhancing ampk/ulk1-mediated autophagy attenuating hepatic steatosis high fat-fructose diet amp-activated protein kinase mesenchymal stem cells hfrd-induced metabolic hazards ccd camera-based imager hfrd-induced metabolic disorders mesenchymal stromal cell hepatic lipogenesis induced improves long-term complications full access t1dm induced model powerful anti-inflammatory character insulin resistance model hoda sayed mahmoud fructose-generated liver steatosis excess acetyl-coa moves metabolite-sensing receptors gpr43 β-sitosterol shows potential embryonic stem cells manar yehia ahmed lung carcinoma transcript-1 high-fat diet references ahmadieh-yazdi biorad trans-blot turbo maha tarek mohammed marwa abdeltawab mohammed hfrd rat model high fructose diet high-fructose diet muscle glucose uptake metabolic hazards induced stem cells therapy adipose tissue level adipose tissue lipogenesis real-time pcr including insulin resistance preventing insulin resistance fat metabolism disorders adipose tissue samples adipose tissue tables 2

Questions {❓}

Moran-Ramos S, Lopez-Contreras BE, Canizales-Quinteros S (2017) Gut microbiota in obesity and metabolic abnormalities: a matter of composition or functionality?

Schema {🗺️}

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         description:High fructose diet (HFrD) has been approved to be involved in the pathogenesis of insulin resistance. Mesenchymal stem cells have a vital role in the treatment of various diseases including metabolic disturbances. We investigated the effect of Adipose-derived mesenchymal stem cells (ADMSCs) against HFrD-induced metabolic disorders and the molecular mechanisms for this effect. Rats were divided into 3 groups; control, HFrD, and combined HFrD with ADMSCs. We assessed liver functions, gut microbiota activity, oxidative stress, adiponectin, and IL10 levels. Also, we measured SREBP-1, IRS-1 expression using Western blot, and Malat1 expression using rt-PCR. ADMSCs antagonized metabolic abnormalities induced by HFrD in the form of improvement of liver functions and alleviation of oxidative stress. In addition, ADMSCs ameliorated gut microbiota activity besides the elevation of adiponectin and IL10 levels. ADMSCs attenuated insulin resistance through upregulation of IRS1 and downregulation of SREBP-1 and Malat1. ADMSCs can protect against HFrD-induced metabolic hazards.
         datePublished:2024-11-05T00:00:00Z
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ScholarlyArticle:
      headline:The effect of adipose-derived mesenchymal stem cells against high fructose diet induced liver dysfunction and dysbiosis
      description:High fructose diet (HFrD) has been approved to be involved in the pathogenesis of insulin resistance. Mesenchymal stem cells have a vital role in the treatment of various diseases including metabolic disturbances. We investigated the effect of Adipose-derived mesenchymal stem cells (ADMSCs) against HFrD-induced metabolic disorders and the molecular mechanisms for this effect. Rats were divided into 3 groups; control, HFrD, and combined HFrD with ADMSCs. We assessed liver functions, gut microbiota activity, oxidative stress, adiponectin, and IL10 levels. Also, we measured SREBP-1, IRS-1 expression using Western blot, and Malat1 expression using rt-PCR. ADMSCs antagonized metabolic abnormalities induced by HFrD in the form of improvement of liver functions and alleviation of oxidative stress. In addition, ADMSCs ameliorated gut microbiota activity besides the elevation of adiponectin and IL10 levels. ADMSCs attenuated insulin resistance through upregulation of IRS1 and downregulation of SREBP-1 and Malat1. ADMSCs can protect against HFrD-induced metabolic hazards.
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      dateModified:2024-11-05T00:00:00Z
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      pageEnd:4537
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         SREBP-1
         NOX4
         MALAT-1
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         Neurosciences
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      name:Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
      name:Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
      name:Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
      name:Department of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
      name:Department of Pharmacology, Faculty of Medicine, Modern University for Technology and Information, Cairo, Egypt

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