We are analyzing https://link.springer.com/article/10.1007/s00210-003-0690-y.

Title:
Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats | Naunyn-Schmiedeberg's Archives of Pharmacology
Description:
The effects of oxytocin (OT) on gastric emptying, gastrointestinal transit, and plasma levels of cholecystokinin (CCK) were studied in female rats. Gastrointestinal motility was assessed in rats 15 min after intragastric instillation of a test meal containing charcoal and Na2 51CrO4. Gastric emptying was determined by measuring the amount of radiolabeled chromium contained in the small intestine as a percentage of the initial amount received. Gastrointestinal transit was evaluated by calculating the geometric center of distribution of the radiolabeled marker. Blood samples were collected for CCK radioimmunoassay. After administration of OT (0.2–0.8 mg/kg), gastric emptying and gastrointestinal transit were inhibited, whereas the plasma concentration of CCK was increased in a dose-dependent manner. Atosiban, an oxytocin receptor antagonist, effectively attenuated the OT- induced inhibition of gastric emptying and gastrointestinal transit. However, administration of atosiban alone had no effect on gastric emptying and gastrointestinal transit. The selective CCK1 receptor antagonists, devazepide and lorglumide, effectively attenuated the OT-induced inhibition of gastric emptying and gastrointestinal transit. L-365, 260, a selective CCK2 receptor antagonist, did not alter the OT-induced inhibition of gastric emptying and gastrointestinal transit. These results suggest that OT inhibits gastric emptying and gastrointestinal transit in female rats via a mechanism involving CCK stimulation and CCK1 receptor activation.
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Keywords {🔍}

google, scholar, cas, pubmed, gastric, cholecystokinin, emptying, gastrointestinal, rats, cck, transit, article, oxytocin, physiol, receptor, rat, wang, chang, pharmacol, brain, effects, receptors, research, intestinal, motility, inhibition, effect, food, intake, sci, chen, privacy, cookies, content, plasma, atosiban, antagonist, access, lee, verbalis, stricker, mchugh, res, usa, moran, taiwan, republic, china, data, publish,

Topics {✒️}

month download article/chapter national yang-ming university national cheng-kung university capsaicin-sensitive vagal pathway l-phenylalanine releases cholecystokinin taipei-veterans general hospital cck-decreased food intake related subjects article naunyn-schmiedeberg' postprandial intestinal motility full article pdf privacy choices/manage cookies central antagonistic activity sex steroid hormones chen-road hung cck1 receptor activation cck receptor antagonists peptide antagonists mk329 chey wy full-young chang induced contractile activity reduced food intake gastric cholecystokinin receptor oxytocin receptor antagonist distinct cholecystokinin receptors subdiaphragmatic vagal branches vagal afferent neurons gastrointestinal propulsion induced european economic area dose-dependent manner rectosigmoid cancer surgery 4-day estrus cycle o-alkylated analogues o'rourke mf electrical spiking activity chen ts ml laboratories plc caerulein-induced delay oxytocin antagonist atosiban peripheral cholecystokinin receptors conditions privacy policy goldrich ms nutritive liquid meal national science council inhibiting gastric emptying radiolabeled chromium contained preterm uterine contractions glutaramic acid derivatives article wu ot- induced inhibition

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