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Title:
Breaking the resistance: integrative approaches with novel therapeutics against Klebsiella pneumoniae | Archives of Microbiology
Description:
Klebsiella pneumoniae is a leading cause of anti-microbial resistance in healthcare-associated infections that have posed a severe threat to neonatal and wider community. The escalating crises of antibiotic resistance have compelled researchers to explore an innovative arsenal beginning from natural resources to chemical modifications in order to overcome the ever-increasing resistance issues. The present review highlights the drug discovery efforts with a special focus on cutting-edge strategies in the hunt for potential drug candidates against MDR/XDR Klebsiella pneumoniae. Nature’s bounty constituting plant extracts, essential oils, fungal extracts, etc. holds promising anti-bacterial potential especially when combined with existing antibiotics. Further, enhancing these natural products with synthetic moieties has improved their effectiveness, creating a bridge between the natural and synthetic world. Conversely, the synthetically modified novel scaffolds have been also designed to meticulously target specific sites. Furthermore, we have also elaborated various emerging strategies for broad-spectrum infections caused by K. pneumoniae, which include anti-microbial peptides, nanotechnology, drug repurposing, bacteriophage, photodynamic, and multidrug therapies. This review further addresses the challenges confronted by the research community and the future way forward in the field of drug discovery against multi-resistant bacterial infections.
Website Age:
28 years and 1 months (reg. 1997-05-29).
Title:
Breaking the resistance: integrative approaches with novel therapeutics against Klebsiella pneumoniae | Archives of Microbiology
Description:
Klebsiella pneumoniae is a leading cause of anti-microbial resistance in healthcare-associated infections that have posed a severe threat to neonatal and wider community. The escalating crises of antibiotic resistance have compelled researchers to explore an innovative arsenal beginning from natural resources to chemical modifications in order to overcome the ever-increasing resistance issues. The present review highlights the drug discovery efforts with a special focus on cutting-edge strategies in the hunt for potential drug candidates against MDR/XDR Klebsiella pneumoniae. Nature’s bounty constituting plant extracts, essential oils, fungal extracts, etc. holds promising anti-bacterial potential especially when combined with existing antibiotics. Further, enhancing these natural products with synthetic moieties has improved their effectiveness, creating a bridge between the natural and synthetic world. Conversely, the synthetically modified novel scaffolds have been also designed to meticulously target specific sites. Furthermore, we have also elaborated various emerging strategies for broad-spectrum infections caused by K. pneumoniae, which include anti-microbial peptides, nanotechnology, drug repurposing, bacteriophage, photodynamic, and multidrug therapies. This review further addresses the challenges confronted by the research community and the future way forward in the field of drug discovery against multi-resistant bacterial infections.
Website Age:
28 years and 1 months (reg. 1997-05-29).
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Keywords {🔍}
pubmed, google, scholar, article, cas, central, pneumoniae, klebsiella, antimicrobial, resistance, drug, microbiol, antibacterial, activity, infect, sci, antibiotics, peptides, review, therapy, resistant, antibiotic, natural, nanoparticles, front, rev, multidrugresistant, chem, singh, infections, synthesis, pathogens, int, repurposing, dis, treatment, combination, med, products, mechanisms, clinical, agents, wang, sharma, strategies, potential, extracts, multidrug, health, bacteria,
Topics {✒️}
grant number-csps24/rdsf/iiim/ihp24/03 retain anti-gram-positive activity month download article/chapter include anti-microbial peptides abuo-rahma ge-da drug-resistant microbial pathogens anti-klebsiella pneumoniae evaluations carbapenem resistant gram-negatives carbapenem-resistant klebsiella pneumoniae oxazolidinone-quinolone hybrid series carbapenem-producing klebsiella pneumoniae multidrug-resistant klebsiella pneumoniae mdr/xdr klebsiella pneumoniae carbapenemase‐producing klebsiella pneumoniae esbl-producing klebsiella pneumoniae combat multidrug-resistant bacteria multi-resistant bacterial infections bis-pyrazole coordination complexes anti-viral drug zidovudine kuljit singh acknowledges antibiotic-resistant klebsiella pneumoniae broad-spectrum infections caused de oliveira ar polymyxin-resistant klebsiella pneumoniae anti-microbial resistance vancomycin-polymyxin nonapeptide conjugates combat multi-antibiotic resistance vitro anti-microbial full article pdf drug-resistant escherichia coli combat eskape pathogens multidrug-resistant phenotypes colistin-resistant escherichia coli pathogenic klebsiella pneumoniae article koul resistant acinetobacter baumannii resistant bacterial pathogens antibacterial natural products drug-resistant pathogens gram-negative bacteria anti-inflammatory drug urinary tract infections kuljit singh multi-drug resistant fda-approved drugs reveal gram-negative strains el-batal ms mediated colistin resistance colistin–sulbactam combination therapy multidrug-resistant bacteria
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headline:Breaking the resistance: integrative approaches with novel therapeutics against Klebsiella pneumoniae
description:Klebsiella pneumoniae is a leading cause of anti-microbial resistance in healthcare-associated infections that have posed a severe threat to neonatal and wider community. The escalating crises of antibiotic resistance have compelled researchers to explore an innovative arsenal beginning from natural resources to chemical modifications in order to overcome the ever-increasing resistance issues. The present review highlights the drug discovery efforts with a special focus on cutting-edge strategies in the hunt for potential drug candidates against MDR/XDR Klebsiella pneumoniae. Nature’s bounty constituting plant extracts, essential oils, fungal extracts, etc. holds promising anti-bacterial potential especially when combined with existing antibiotics. Further, enhancing these natural products with synthetic moieties has improved their effectiveness, creating a bridge between the natural and synthetic world. Conversely, the synthetically modified novel scaffolds have been also designed to meticulously target specific sites. Furthermore, we have also elaborated various emerging strategies for broad-spectrum infections caused by K. pneumoniae, which include anti-microbial peptides, nanotechnology, drug repurposing, bacteriophage, photodynamic, and multidrug therapies. This review further addresses the challenges confronted by the research community and the future way forward in the field of drug discovery against multi-resistant bacterial infections.
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headline:Breaking the resistance: integrative approaches with novel therapeutics against Klebsiella pneumoniae
description:Klebsiella pneumoniae is a leading cause of anti-microbial resistance in healthcare-associated infections that have posed a severe threat to neonatal and wider community. The escalating crises of antibiotic resistance have compelled researchers to explore an innovative arsenal beginning from natural resources to chemical modifications in order to overcome the ever-increasing resistance issues. The present review highlights the drug discovery efforts with a special focus on cutting-edge strategies in the hunt for potential drug candidates against MDR/XDR Klebsiella pneumoniae. Nature’s bounty constituting plant extracts, essential oils, fungal extracts, etc. holds promising anti-bacterial potential especially when combined with existing antibiotics. Further, enhancing these natural products with synthetic moieties has improved their effectiveness, creating a bridge between the natural and synthetic world. Conversely, the synthetically modified novel scaffolds have been also designed to meticulously target specific sites. Furthermore, we have also elaborated various emerging strategies for broad-spectrum infections caused by K. pneumoniae, which include anti-microbial peptides, nanotechnology, drug repurposing, bacteriophage, photodynamic, and multidrug therapies. This review further addresses the challenges confronted by the research community and the future way forward in the field of drug discovery against multi-resistant bacterial infections.
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Natural products
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Microbial Ecology
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