We are analyzing https://link.springer.com/article/10.1007/s00198-009-1119-3.

Title:
Benefit–risk assessment of vitamin D supplementation | Osteoporosis International
Description:
Current intake recommendations of 200 to 600 IU vitamin D per day may be insufficient for important disease outcomes reduced by vitamin D. This study assessed the benefit of higher-dose and higher achieved 25-hydroxyvitamin D levels [25(OH)D] versus any associated risk. Based on double-blind randomized control trials (RCTs), eight for falls (n = 2426) and 12 for non-vertebral fractures (n = 42,279), there was a significant dose–response relationship between higher-dose and higher achieved 25(OH)D and greater fall and fracture prevention. Optimal benefits were observed at the highest dose tested to date for 700 to 1000 IU vitamin D per day or mean 25(OH)D between 75 and 110 nmol/l (30–44 ng/ml). Prospective cohort data on cardiovascular health and colorectal cancer prevention suggested increased benefits with the highest categories of 25(OH)D evaluated (median between 75 and 110 nmol/l). In 25 RCTs, mean serum calcium levels were not related to oral vitamin D up to 100,000 IU per day or achieved 25(OH)D up to 643 nmol/l. Mean levels of 75 to 110 nmol/l were reached in most RCTs with 1,800 to 4,000 IU vitamin D per day without risk. Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.
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Topics {✒️}

month download article/chapter bischoff-ferrari ha randomised placebo-controlled trial article bischoff-ferrari benefit–risk assessment nursing home residents randomized double-blind trial placebo-controlled clinical trial bischoff-ferrari council community-dwelling older individuals bischoff-ferrari department significant dose–response relationship chronic kidney disease high-dose ergocalciferol supplementation full article pdf privacy choices/manage cookies dietary supplement-induced vitamin home-delivery dairy daily low-dose vitamin placebo-controlled trial bischoff-ferrari bischoff-ferrari randomized controlled trials placebo-controlled study randomized controlled trial high-dose ergocalciferol colorectal cancer prevention risk assessment unrestricted grant provided increased bone resorption corticosteroid-induced osteopenia quantitative meta analysis dawson-hughes department parathyroid hormone levels provide optimal benefits randomized clinical trial cardiovascular disease mortality low-trauma fractures european economic area scope submit manuscript nutrition examination survey beta cell dysfunction anti-tumor activity negative endocrine regulator renin-angiotensin system middle-aged norwegians congestive heart failure supplements extended oral dosing graded oral dosing

Questions {❓}

Flicker L et al (2004) Should all older people in residential care receive vitamin D to prevent falls?
Meyer HE et al (2002) Can vitamin D supplementation reduce the risk of fracture in the elderly?

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         description:Current intake recommendations of 200 to 600 IU vitamin D per day may be insufficient for important disease outcomes reduced by vitamin D. This study assessed the benefit of higher-dose and higher achieved 25-hydroxyvitamin D levels [25(OH)D] versus any associated risk. Based on double-blind randomized control trials (RCTs), eight for falls (n = 2426) and 12 for non-vertebral fractures (n = 42,279), there was a significant dose–response relationship between higher-dose and higher achieved 25(OH)D and greater fall and fracture prevention. Optimal benefits were observed at the highest dose tested to date for 700 to 1000 IU vitamin D per day or mean 25(OH)D between 75 and 110 nmol/l (30–44 ng/ml). Prospective cohort data on cardiovascular health and colorectal cancer prevention suggested increased benefits with the highest categories of 25(OH)D evaluated (median between 75 and 110 nmol/l). In 25 RCTs, mean serum calcium levels were not related to oral vitamin D up to 100,000 IU per day or achieved 25(OH)D up to 643 nmol/l. Mean levels of 75 to 110 nmol/l were reached in most RCTs with 1,800 to 4,000 IU vitamin D per day without risk. Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.
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