We are analyzing https://link.springer.com/article/10.1007/s001250100032.

Title:
Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus | Diabetologia
Description:
Aim/hypothesis: This study aimed to investigate if variability in the peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) gene is associated with Type II (non-insulin-dependent) diabetes mellitus. Methods: The PGC-1 gene was examined in 53 Type II diabetic patients applying single strand conformational polymorphism analysis followed by nucleotide sequencing. Identified variants were genotyped in an association study comprising 483 Type II diabetic patients and 216 glucose-tolerant control subjects. A replication study was done in an additional 201 Type II diabetic patients and 293 glucose-tolerant subjects. Furthermore, a potential interaction between the Pro12Ala polymorphism of PPAR- γ2 and the PGC-1 Gly482Ser variant on risk of Type II diabetes was investigated. Results: A total of seven variants (Ser74Leu, IVS2 + 52C→A, Thr394Thr, Asp475Asp, Gly482Ser, Thr528Thr, and Thr612Met) were identified and investigated in an association study. Six of the variants showed no association with Type II diabetes in the initial study. However, the Gly482Ser polymorphism, was more frequent among Type II diabetic patients (37.0 %) than among glucose-tolerant subjects (30.8 %) (p = 0.032). In a replication study the difference in allele frequencies of the Gly482Ser variant remained significant (p = 0.0135). The combined study yielded an allele frequency of 37.3 % (34.7–39.9) for Type II diabetic patients and 30.5 % (27.7–33.4) for glucose-tolerant subjects (p = 0.0007). No interaction between this variant and the Pro12Ala polymorphism of PPAR- γ2 was observed. Conclusion/interpretation: A widespread Gly482Ser polymorphism of PGC-1 is associated with a 1.34 genotype relative risk of Type II diabetes. [Diabetologia (2001) 44: 2220–2226]
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

type, diabetes, article, study, polymorphism, pgc, subjects, privacy, cookies, peroxisome, diabetic, patients, association, glyser, content, analysis, information, publish, research, search, diabetologia, proliferatoractivated, coactivator, identified, glucosetolerant, data, journal, receptorγ, mellitus, download, andersen, urhammer, variants, proala, variant, risk, pparγ, open, access, discover, optional, personal, parties, policy, find, track, mutation, relationships, amino, acid,

Topics {✒️}

type ii diabetes association study hagedorn research institute type ii combined study yielded privacy choices/manage cookies diabetes mellitus 293 glucose-tolerant subjects glucose-tolerant subjects mutation analysis related subjects main content log european economic area glostrup university hospital widespread gly482ser polymorphism conditions privacy policy accepting optional cookies scope submit manuscript search search ppar- γ2 association usage analysis journal finder publish study aimed replication study initial study diabetes pgc-1 gly482ser variant article cite article ek gly482ser polymorphism privacy policy personal data pedersen centre books a pro12ala polymorphism c1431t polymorphism information optional cookies manage preferences data protection essential cookies cookies skip identified variants journal publish social media varying standards december 2001 volume 44 borch-johnsen aim/hypothesis

Schema {🗺️}

WebPage:
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         headline:Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus
         description: This study aimed to investigate if variability in the peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) gene is associated with Type II (non-insulin-dependent) diabetes mellitus. The PGC-1 gene was examined in 53 Type II diabetic patients applying single strand conformational polymorphism analysis followed by nucleotide sequencing. Identified variants were genotyped in an association study comprising 483 Type II diabetic patients and 216 glucose-tolerant control subjects. A replication study was done in an additional 201 Type II diabetic patients and 293 glucose-tolerant subjects. Furthermore, a potential interaction between the Pro12Ala polymorphism of PPAR- γ2 and the PGC-1 Gly482Ser variant on risk of Type II diabetes was investigated. A total of seven variants (Ser74Leu, IVS2 + 52C→A, Thr394Thr, Asp475Asp, Gly482Ser, Thr528Thr, and Thr612Met) were identified and investigated in an association study. Six of the variants showed no association with Type II diabetes in the initial study. However, the Gly482Ser polymorphism, was more frequent among Type II diabetic patients (37.0 %) than among glucose-tolerant subjects (30.8 %) (p = 0.032). In a replication study the difference in allele frequencies of the Gly482Ser variant remained significant (p = 0.0135). The combined study yielded an allele frequency of 37.3 % (34.7–39.9) for Type II diabetic patients and 30.5 % (27.7–33.4) for glucose-tolerant subjects (p = 0.0007). No interaction between this variant and the Pro12Ala polymorphism of PPAR- γ2 was observed. A widespread Gly482Ser polymorphism of PGC-1 is associated with a 1.34 genotype relative risk of Type II diabetes. [Diabetologia (2001) 44: 2220–2226]
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         keywords:
            Keywords PPAR-γ coactivator-1
            mutations
            Type II diabetes
            genetic epidemiology
            association study.
            Internal Medicine
            Metabolic Diseases
            Human Physiology
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      headline:Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus
      description: This study aimed to investigate if variability in the peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) gene is associated with Type II (non-insulin-dependent) diabetes mellitus. The PGC-1 gene was examined in 53 Type II diabetic patients applying single strand conformational polymorphism analysis followed by nucleotide sequencing. Identified variants were genotyped in an association study comprising 483 Type II diabetic patients and 216 glucose-tolerant control subjects. A replication study was done in an additional 201 Type II diabetic patients and 293 glucose-tolerant subjects. Furthermore, a potential interaction between the Pro12Ala polymorphism of PPAR- γ2 and the PGC-1 Gly482Ser variant on risk of Type II diabetes was investigated. A total of seven variants (Ser74Leu, IVS2 + 52C→A, Thr394Thr, Asp475Asp, Gly482Ser, Thr528Thr, and Thr612Met) were identified and investigated in an association study. Six of the variants showed no association with Type II diabetes in the initial study. However, the Gly482Ser polymorphism, was more frequent among Type II diabetic patients (37.0 %) than among glucose-tolerant subjects (30.8 %) (p = 0.032). In a replication study the difference in allele frequencies of the Gly482Ser variant remained significant (p = 0.0135). The combined study yielded an allele frequency of 37.3 % (34.7–39.9) for Type II diabetic patients and 30.5 % (27.7–33.4) for glucose-tolerant subjects (p = 0.0007). No interaction between this variant and the Pro12Ala polymorphism of PPAR- γ2 was observed. A widespread Gly482Ser polymorphism of PGC-1 is associated with a 1.34 genotype relative risk of Type II diabetes. [Diabetologia (2001) 44: 2220–2226]
      datePublished:
      dateModified:
      pageStart:2220
      pageEnd:2226
      sameAs:https://doi.org/10.1007/s001250100032
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         Keywords PPAR-γ coactivator-1
         mutations
         Type II diabetes
         genetic epidemiology
         association study.
         Internal Medicine
         Metabolic Diseases
         Human Physiology
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               type:PostalAddress
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               type:PostalAddress
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      name:T. Hansen
      affiliation:
            name:Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
            address:
               name:Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark, , DK
               type:PostalAddress
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      affiliation:
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            address:
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      name:Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark, , DK
      name:Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark, , DK
      name:Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark, , DK
      name:Centre of Preventive Medicine, Glostrup University Hospital, Denmark, , DK
      name:Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark, , DK
      name:Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark, , DK
      name:Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark, , DK

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