We are analyzing https://link.springer.com/article/10.1007/s001250051551.

Title:
Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus | Diabetologia
Description:
Aims/hypothesis. Tetrahydrobiopterin is an essential cofactor of nitric oxide synthase, and its deficiency decreases nitric oxide bioactivity. Our aim was to find whether supplementation of tetrahydrobiopterin could improve endothelial dysfunction in diabetic patients.¶Methods. Forearm blood flow responses to the endothelium-dependent vasodilator acetylcholine (0.75– 3.0 μg · 100 ml–1· min–1) and to the endothelium-independent vasodilator sodium nitroprusside (0.1–1.0 μg · 100 ml–1· min–1) before and during concomitant intra-arterial infusion of tetrahydrobiopterin (500 μg/min) were measured by venous occlusion plethysmography in 12 control subjects and 23 patients with Type II (non-insulin-dependent) diabetes mellitus.¶Results. In control subjects, tetrahydrobiopterin had no effect on the dose-response curves to acetylcholine and sodium nitroprusside. In contrast, in diabetic patients, the attenuated endothelium-dependent vasodilation to acetylcholine was considerably improved by concomitant treatment with tetrahydrobiopterin, whereas the endothelium-independent vasodilation was not affected. This beneficial effect of tetrahydrobiopterin in diabetic patients could be completely blocked by N G-monomethyl-l-arginine.¶Conclusion/interpretation. These findings suggest the possibility that endothelial dysfunction in Type II diabetes might be related to decreased availability of tetrahydrobiopterin. [Diabetologia (2000) 43: 1435–1438]
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Mobile Technology & AI
Social Networks
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

tetrahydrobiopterin, diabetes, article, vasodilation, nitric, oxide, patients, type, privacy, cookies, endotheliumdependent, endothelial, content, information, publish, search, diabetologia, mellitus, dysfunction, diabetic, acetylcholine, subjects, data, find, journal, research, download, heitzer, krohn, albers, related, discover, essential, function, optional, personal, parties, policy, track, improves, increasing, activity, cite, pdf, manuscript, meinertz, explore, improve, vasodilator, min,

Topics {✒️}

attenuated endothelium-dependent vasodilation g-monomethyl-l-arginine ng-monomethyl-l-arginine endothelium-dependent vasodilation endothelium-dependent vasodilator acetylcholine concomitant intra-arterial infusion endothelium-independent vasodilation type ii diabetes improve endothelial dysfunction nitric oxide synthase privacy choices/manage cookies main content log search search european economic area venous occlusion plethysmography dose-response curves type 2 diabetes nitric oxide conditions privacy policy type ii diabetes mellitus accepting optional cookies scope submit manuscript endothelial dysfunction journal finder publish sodium nitroprusside insulin-dependent article cite article heitzer diabetic patients related subjects privacy policy personal data books a 500 μg/min optional cookies manage preferences 12 control subjects control subjects concomitant treatment data protection essential cookies cookies skip information [diabetologia diabetologia 43 endothelium journal publish usage analysis social media

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
         description: Aims/hypothesis. Tetrahydrobiopterin is an essential cofactor of nitric oxide synthase, and its deficiency decreases nitric oxide bioactivity. Our aim was to find whether supplementation of tetrahydrobiopterin could improve endothelial dysfunction in diabetic patients.¶Methods. Forearm blood flow responses to the endothelium-dependent vasodilator acetylcholine (0.75– 3.0 μg · 100 ml–1· min–1) and to the endothelium-independent vasodilator sodium nitroprusside (0.1–1.0 μg · 100 ml–1· min–1) before and during concomitant intra-arterial infusion of tetrahydrobiopterin (500 μg/min) were measured by venous occlusion plethysmography in 12 control subjects and 23 patients with Type II (non-insulin-dependent) diabetes mellitus.¶Results. In control subjects, tetrahydrobiopterin had no effect on the dose-response curves to acetylcholine and sodium nitroprusside. In contrast, in diabetic patients, the attenuated endothelium-dependent vasodilation to acetylcholine was considerably improved by concomitant treatment with tetrahydrobiopterin, whereas the endothelium-independent vasodilation was not affected. This beneficial effect of tetrahydrobiopterin in diabetic patients could be completely blocked by N G-monomethyl-l-arginine.¶Conclusion/interpretation. These findings suggest the possibility that endothelial dysfunction in Type II diabetes might be related to decreased availability of tetrahydrobiopterin. [Diabetologia (2000) 43: 1435–1438]
         datePublished:
         dateModified:
         pageStart:1435
         pageEnd:1438
         sameAs:https://doi.org/10.1007/s001250051551
         keywords:
            Keywords Diabetes mellitus, endothelium, nitric oxide, tetrahydrobiopterin, endothelium-dependent vasodilation, acetylcholine, NG-monomethyl-l-arginine.
            Internal Medicine
            Metabolic Diseases
            Human Physiology
         image:
         isPartOf:
            name:Diabetologia
            issn:
               1432-0428
               0012-186X
            volumeNumber:43
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:T. Heitzer
               affiliation:
                     name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
                     address:
                        name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
                        type:PostalAddress
                     type:Organization
               type:Person
               name:K. Krohn
               affiliation:
                     name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
                     address:
                        name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
                        type:PostalAddress
                     type:Organization
               type:Person
               name:S. Albers
               affiliation:
                     name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
                     address:
                        name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
                        type:PostalAddress
                     type:Organization
               type:Person
               name:T. Meinertz
               affiliation:
                     name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
                     address:
                        name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
      description: Aims/hypothesis. Tetrahydrobiopterin is an essential cofactor of nitric oxide synthase, and its deficiency decreases nitric oxide bioactivity. Our aim was to find whether supplementation of tetrahydrobiopterin could improve endothelial dysfunction in diabetic patients.¶Methods. Forearm blood flow responses to the endothelium-dependent vasodilator acetylcholine (0.75– 3.0 μg · 100 ml–1· min–1) and to the endothelium-independent vasodilator sodium nitroprusside (0.1–1.0 μg · 100 ml–1· min–1) before and during concomitant intra-arterial infusion of tetrahydrobiopterin (500 μg/min) were measured by venous occlusion plethysmography in 12 control subjects and 23 patients with Type II (non-insulin-dependent) diabetes mellitus.¶Results. In control subjects, tetrahydrobiopterin had no effect on the dose-response curves to acetylcholine and sodium nitroprusside. In contrast, in diabetic patients, the attenuated endothelium-dependent vasodilation to acetylcholine was considerably improved by concomitant treatment with tetrahydrobiopterin, whereas the endothelium-independent vasodilation was not affected. This beneficial effect of tetrahydrobiopterin in diabetic patients could be completely blocked by N G-monomethyl-l-arginine.¶Conclusion/interpretation. These findings suggest the possibility that endothelial dysfunction in Type II diabetes might be related to decreased availability of tetrahydrobiopterin. [Diabetologia (2000) 43: 1435–1438]
      datePublished:
      dateModified:
      pageStart:1435
      pageEnd:1438
      sameAs:https://doi.org/10.1007/s001250051551
      keywords:
         Keywords Diabetes mellitus, endothelium, nitric oxide, tetrahydrobiopterin, endothelium-dependent vasodilation, acetylcholine, NG-monomethyl-l-arginine.
         Internal Medicine
         Metabolic Diseases
         Human Physiology
      image:
      isPartOf:
         name:Diabetologia
         issn:
            1432-0428
            0012-186X
         volumeNumber:43
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:T. Heitzer
            affiliation:
                  name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
                  address:
                     name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
                     type:PostalAddress
                  type:Organization
            type:Person
            name:K. Krohn
            affiliation:
                  name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
                  address:
                     name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
                     type:PostalAddress
                  type:Organization
            type:Person
            name:S. Albers
            affiliation:
                  name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
                  address:
                     name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
                     type:PostalAddress
                  type:Organization
            type:Person
            name:T. Meinertz
            affiliation:
                  name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
                  address:
                     name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Diabetologia
      issn:
         1432-0428
         0012-186X
      volumeNumber:43
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
      address:
         name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
         type:PostalAddress
      name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
      address:
         name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
         type:PostalAddress
      name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
      address:
         name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
         type:PostalAddress
      name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
      address:
         name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:T. Heitzer
      affiliation:
            name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
            address:
               name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
               type:PostalAddress
            type:Organization
      name:K. Krohn
      affiliation:
            name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
            address:
               name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
               type:PostalAddress
            type:Organization
      name:S. Albers
      affiliation:
            name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
            address:
               name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
               type:PostalAddress
            type:Organization
      name:T. Meinertz
      affiliation:
            name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany
            address:
               name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
               type:PostalAddress
            type:Organization
PostalAddress:
      name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
      name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
      name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE
      name:University Hospital Clinic Hamburg-Eppendorf, Department of Cardiology, Clinic for Internal Medicine, Hamburg, Germany, , DE

External Links {🔗}(31)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.82s.

LINK . SPRINGER . COM {}