We are analyzing https://link.springer.com/article/10.1007/s00109-025-02553-w.

Title:
The role of innate immunity triggered by HPV infection in promoting cervical lesions | Journal of Molecular Medicine
Description:
Innate immunity is the immune system that organisms possess from birth. It is primarily responsible for the rapid, nonspecific recognition of pathogens when they invade, activating the host’s immune response to eliminate. Cervical cancer is one of the most well-known tumors caused by human papillomavirus (HPV) infection. As the first line of defense against pathogens, innate immunity plays a crucial role in the response to HPV invasion, and there has been significant research in this area in recent years. The findings suggest that innate immune responses not only contribute to the clearance of HPV but may also facilitate the spread of the virus and the carcinogenic transformation of cervical epithelial cells. In this review, we comprehensively examine the activation of innate immune responses during HPV infection, the mechanisms by which HPV evades these immune defenses, and the role of innate immunity in promoting cervical intraepithelial neoplasia. Additionally, we explore the characteristics of innate immune responses within the tumor microenvironment of cervical cancer. Furthermore, we summarize recent advances in understanding the various mechanisms by which innate immune responses can be activated, with a focus on potential therapeutic implications. By reviewing the latest research, this article aims to provide valuable insights and stimulate further investigation into the role of innate immunity in HPV-associated cervical lesions, potentially leading to more effective strategies for prevention and treatment in the future.
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Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, cervical, innate, central, human, immune, papillomavirus, cells, immunity, hpv, cell, infection, med, role, immunol, virol, journal, res, response, expression, front, tlr, immunotherapy, authors, content, research, lesions, manuscript, zhang, responses, activation, tolllike, type, study, molecular, rutie, yin, tumor, microenvironment, therapeutic, access, host, nature, mol, clin,

Topics {✒️}

host nf-κb/c-myc cgas-sting dna-sensing pathway sting-tbk1-nf-kb pathway single-nucleus rna sequencing single-cell rna sequencing myeloid anti-tumor immunity suv39h1-mediated epigenetic silencing month download article/chapter nf-ĸb-independent manner human papillomavirus-induced oncogenesis heterotetrameric annexin a2/s100a10 cgas-sting-mediated stat-dependent chemokine production host innate immunity hpv-mediated cervical cancer innate immunity triggered innate immune response cervical cancer-produced neuromedin cgas/sting surveillance dna damage response cervical intraepithelial neoplasia cervico-vaginal microbiota-evidence host immune system innate immune sensing cervical epithelial cells innate immune responses human papillomavirus oncoproteins minor capsid protein gene expression variability full article pdf viral evasion strategies hpv-positive women innate immunity plays humoral innate immunity suppressing innate immunity squamous cell carcinoma innate immune system dna damage repair genomic risk factors sting agonist inflames human papillomavirus infection human papillomavirus infections tlr3-triggered migration macrophages suppress antitumor human cervical cancer adhesion molecule markers privacy choices/manage cookies generation sequencing studies blunts therapy-induced cervical cells differs

Questions {❓}

Warren CJ, Santiago ML, Pyeon D (2022) APOBEC3: friend or foe in human papillomavirus infection and oncogenesis?

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