We are analyzing https://link.springer.com/article/10.1007/s00109-004-0555-y.

Title:
Nuclear factor-κB: its role in health and disease | Journal of Molecular Medicine
Description:
Nuclear factor-κB (NF-κB) is a major transcription factor that plays an essential role in several aspects of human health including the development of innate and adaptive immunity. The dysregulation of NF-κB is associated with many disease states such as AIDS, atherosclerosis, asthma, arthritis, cancer, diabetes, inflammatory bowel disease, muscular dystrophy, stroke, and viral infections. Recent evidence also suggests that the dysfunction of NF-κB is a major mediator of some human genetic disorders. Appropriate regulation and control of NF-κB activity, which can be achieved by gene modification or pharmacological strategies, would provide a potential approach for the management of NF-κB related human diseases. This review summarizes the current knowledge of the physiological and pathophysiological functions of NF-κB and its possible role as a target of therapeutic intervention
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Keywords {🔍}

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Topics {✒️}

myeloid-related cd8alpha-dendritic cells rel/nf-kappab transcription factors month download article/chapter increased nf-kappab-mediated transcription amyloid beta-peptide toxicity enhanced anti-tumor therapy mitogen-activated protein kinases ikappab alpha/nf-kappab pathway ikappabalpha/nf-kappab survival pathway c-jun transcription factors cytokine-induced nf-kappab activation activated nuclear factor-kappab myotrophin-induced cardiac hypertrophy tumor necrosis factor-alpha nuclear transcription factor-kappab transcription factor nf-κb nuclear factor-kappab pathway germ-line ch transcription map3k-related kinase involved kappa b-binding factor syk protein-tyrosine kinase cytokine-induced neutrophil chemoattractant transcription factor nf-kappab nf-kappab transcription factor nf-kappabp65/ikappabalpha system blocking nf-kappab inhibits t-lineage cells leads rat pancreatic beta-cells cell-mediated immune responses diet-induced insulin resistance site-specific tyrosine phosphorylation nf-kappab signalling pathway sequential dna damage-independent nf-kappab signalling cascades aberrant rel/nfkb genes c-src-dependent mechanism il-1-induced bone resorption cytokine-responsive ikappab kinase situ nf-kappab expression ikk/nf-kappab pathway ikappab kinase-independent mechanism ozone-induced il-8 expression nuclear transcription factors nemo/ikkgamma-deficient mice spares anti-inflammatory mediators transcription factor binding anti-inflammatory agents aspirin tumor necrosis factor nuclear factor-κb transcription factor lyt-10

Questions {❓}

Collins T, Cybulsky MI (2001) NF-kappaB: pivotal mediator or innocent bystander in atherogenesis?
Do immune cells promote the pathology of dystrophin-deficient myopathies?
Li N, Karin M (1999) Is NF-kappaB the sensor of oxidative stress?
Purcell NH, Molkentin JD (2003) Is nuclear factor kappaB an attractive therapeutic target for treating cardiac hypertrophy?

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