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We are analyzing https://link.springer.com/article/10.1007/s000180050488.

Title:
The active role of astrocytes in synaptic transmission | Cellular and Molecular Life Sciences
Description:
In the central nervous system, astrocytes form an intimately connected network with neurons, and their processes closely enwrap synapses. The critical role of these cells in metabolic and trophic support to neurons, ion buffering and clearance of neurotransmitters is well established. However, recent accumulating evidence suggests that astrocytes are active partners of neurons in additional and more complex functions. In particular, astrocytes express a repertoire of neurotransmitter receptors mirroring that of neighbouring synapses. Such receptors are stimulated during synaptic activity and start calcium signalling into the astrocyte network. Intracellular oscillations and intercellular calcium waves represent the astrocyte’s own form of excitability, as they trigger release of transmitter (i.e. glutamate) via a novel process sensitive to blockers of exocytosis and involving cyclooxygenase eicosanoids. Astrocyte-released glutamate activates receptors on the surrounding neurons and modifies their electrical and intracellular calcium ([Ca2+]i) state. These exciting new findings reveal an active participation of astrocytes in synaptic transmission and the involvement of neuron-astrocyte circuits in the processing of information in the brain.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Telecommunications
  • Mobile Technology & AI
  • Social Networks

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

article, astrocytes, synaptic, calcium, privacy, cookies, content, information, transmission, publish, search, active, neurons, access, data, log, journal, research, life, sciences, cmls, role, vesce, bezzi, volterra, network, synapses, receptors, signalling, astrocyte, glutamate, discover, springer, optional, processing, personal, parties, policy, find, track, cellular, molecular, cite, explore, nervous, system, form, support, ion, neurotransmitters,

Topics {✒️}

month download article/chapter central nervous system privacy choices/manage cookies start calcium signalling intimately connected network full article pdf related subjects neuron-astrocyte circuits european economic area scope submit manuscript neurotransmitter receptors mirroring involving cyclooxygenase eicosanoids neuron-glia interaction conditions privacy policy accepting optional cookies astrocyte network main content log calcium signalling journal finder publish article cellular synaptic transmission ion buffering pharmacological sciences life sci privacy policy personal data neighbouring synapses article log trophic support intracellular calcium books a synaptic activity optional cookies article cite manage preferences active partners check access instant access article vesce data protection essential cookies cookies skip subscription content similar content neurotransmitters institution subscribe journal publish usage analysis social media varying standards

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The active role of astrocytes in synaptic transmission
         description: In the central nervous system, astrocytes form an intimately connected network with neurons, and their processes closely enwrap synapses. The critical role of these cells in metabolic and trophic support to neurons, ion buffering and clearance of neurotransmitters is well established. However, recent accumulating evidence suggests that astrocytes are active partners of neurons in additional and more complex functions. In particular, astrocytes express a repertoire of neurotransmitter receptors mirroring that of neighbouring synapses. Such receptors are stimulated during synaptic activity and start calcium signalling into the astrocyte network. Intracellular oscillations and intercellular calcium waves represent the astrocyte’s own form of excitability, as they trigger release of transmitter (i.e. glutamate) via a novel process sensitive to blockers of exocytosis and involving cyclooxygenase eicosanoids. Astrocyte-released glutamate activates receptors on the surrounding neurons and modifies their electrical and intracellular calcium ([Ca2+]i) state. These exciting new findings reveal an active participation of astrocytes in synaptic transmission and the involvement of neuron-astrocyte circuits in the processing of information in the brain.
         datePublished:
         dateModified:
         pageStart:991
         pageEnd:1000
         sameAs:https://doi.org/10.1007/s000180050488
         keywords:
            Key words. Astrocytes; neuron-glia interaction; synaptic transmission; glutamate; calcium signalling; prostaglandins; transmitter release.
            Cell Biology
            Biomedicine
            general
            Life Sciences
            Biochemistry
         image:
         isPartOf:
            name:Cellular and Molecular Life Sciences CMLS
            issn:
               1420-9071
               1420-682X
            volumeNumber:56
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Birkhäuser Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:S. Vesce
               affiliation:
                     name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected]
                     address:
                        name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected], , IT
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                        name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected], , IT
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ScholarlyArticle:
      headline:The active role of astrocytes in synaptic transmission
      description: In the central nervous system, astrocytes form an intimately connected network with neurons, and their processes closely enwrap synapses. The critical role of these cells in metabolic and trophic support to neurons, ion buffering and clearance of neurotransmitters is well established. However, recent accumulating evidence suggests that astrocytes are active partners of neurons in additional and more complex functions. In particular, astrocytes express a repertoire of neurotransmitter receptors mirroring that of neighbouring synapses. Such receptors are stimulated during synaptic activity and start calcium signalling into the astrocyte network. Intracellular oscillations and intercellular calcium waves represent the astrocyte’s own form of excitability, as they trigger release of transmitter (i.e. glutamate) via a novel process sensitive to blockers of exocytosis and involving cyclooxygenase eicosanoids. Astrocyte-released glutamate activates receptors on the surrounding neurons and modifies their electrical and intracellular calcium ([Ca2+]i) state. These exciting new findings reveal an active participation of astrocytes in synaptic transmission and the involvement of neuron-astrocyte circuits in the processing of information in the brain.
      datePublished:
      dateModified:
      pageStart:991
      pageEnd:1000
      sameAs:https://doi.org/10.1007/s000180050488
      keywords:
         Key words. Astrocytes; neuron-glia interaction; synaptic transmission; glutamate; calcium signalling; prostaglandins; transmitter release.
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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            PublicationVolume
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         name:Birkhäuser Verlag
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            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
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      author:
            name:S. Vesce
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                  name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected]
                  address:
                     name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected], , IT
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            name:P. Bezzi
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                     name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected], , IT
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                  type:Organization
            type:Person
            name:A. Volterra
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                  name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected]
                  address:
                     name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected], , IT
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      volumeNumber:56
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      name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected]
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         name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected], , IT
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         name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected], , IT
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            name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected]
            address:
               name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected], , IT
               type:PostalAddress
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      name:P. Bezzi
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            name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected]
            address:
               name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected], , IT
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      name:A. Volterra
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            name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected]
            address:
               name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected], , IT
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      name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected], , IT
      name:Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, I-20133 Milan (Italy), Fax +39 02 29404961, e-mail: [email protected], , IT
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