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Title:
Activation of immediate early genes and memory formation | Cellular and Molecular Life Sciences
Description:
Long-term plastic changes in the brain, including those supporting memory formation, are assumed to depend on permanent functional alterations in neuronal cells that require reprogramming of gene expression. Inducible transcription factors encoded by immediate arly genes such as c-fos, c-jun, jun-B and zif /268 (also known as krox-24, egr-1, TIS 8, NGFI-A or zenk) are supposed to act as messengers in coupling short-term neuronal activity with changes at the level of gene transcription. This review will summarize studies on the expression of transcription factor-encoding immediate early genes in the vertebrate brain during behavioral training. Special emphasis will be given to correlative or interventive experimental evidence indicative of a physiological significance of inducible transcription factors for processes underlying learning and memory formation.
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article, memory, transcription, gene, privacy, cookies, content, genes, information, publish, research, search, early, formation, access, data, log, journal, life, cmls, tischmeyer, grimm, brain, neuronal, expression, factors, learning, discover, springer, optional, personal, including, parties, policy, find, track, cellular, molecular, sciences, activation, cite, explore, supporting, inducible, institution, related, subjects, author, rights, permissions,
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inducible transcription factors month download article/chapter transcription factor-encoding supporting memory formation gene transcription gene-expression correlates privacy choices/manage cookies related subjects full article pdf long-term plastic gene expression transcription factor european economic area scope submit manuscript permanent functional alterations dimensional genome restructuring early gene conditions privacy policy memory formation accepting optional cookies processes underlying learning article cellular main content log journal finder publish early genes arly genes neuronal cells life sci article log article tischmeyer article cite privacy policy personal data memory information books a optional cookies manage preferences check access instant access data protection essential cookies cookies skip subscription content similar content research d-39008 magdeburg institution subscribe journal publish usage analysis
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headline:Activation of immediate early genes and memory formation
description: Long-term plastic changes in the brain, including those supporting memory formation, are assumed to depend on permanent functional alterations in neuronal cells that require reprogramming of gene expression. Inducible transcription factors encoded by immediate arly genes such as c-fos, c-jun, jun-B and zif /268 (also known as krox-24, egr-1, TIS 8, NGFI-A or zenk) are supposed to act as messengers in coupling short-term neuronal activity with changes at the level of gene transcription. This review will summarize studies on the expression of transcription factor-encoding immediate early genes in the vertebrate brain during behavioral training. Special emphasis will be given to correlative or interventive experimental evidence indicative of a physiological significance of inducible transcription factors for processes underlying learning and memory formation.
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dateModified:
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Key words. Immediate early gene; transcription factor; learning; memory; brain; antisense.
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description: Long-term plastic changes in the brain, including those supporting memory formation, are assumed to depend on permanent functional alterations in neuronal cells that require reprogramming of gene expression. Inducible transcription factors encoded by immediate arly genes such as c-fos, c-jun, jun-B and zif /268 (also known as krox-24, egr-1, TIS 8, NGFI-A or zenk) are supposed to act as messengers in coupling short-term neuronal activity with changes at the level of gene transcription. This review will summarize studies on the expression of transcription factor-encoding immediate early genes in the vertebrate brain during behavioral training. Special emphasis will be given to correlative or interventive experimental evidence indicative of a physiological significance of inducible transcription factors for processes underlying learning and memory formation.
datePublished:
dateModified:
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pageEnd:574
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Biochemistry
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