We are analyzing https://link.springer.com/article/10.1007/s00018-023-05070-6.

Title:
Emerging roles of mitochondrial functions and epigenetic changes in the modulation of stem cell fate | Cellular and Molecular Life Sciences
Description:
Mitochondria serve as essential organelles that play a key role in regulating stem cell fate. Mitochondrial dysfunction and stem cell exhaustion are two of the nine distinct hallmarks of aging. Emerging research suggests that epigenetic modification of mitochondria-encoded genes and the regulation of epigenetics by mitochondrial metabolites have an impact on stem cell aging or differentiation. Here, we review how key mitochondrial metabolites and behaviors regulate stem cell fate through an epigenetic approach. Gaining insight into how mitochondria regulate stem cell fate will help us manufacture and preserve clinical-grade stem cells under strict quality control standards, contributing to the development of aging-associated organ dysfunction and disease.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, stem, cell, article, mitochondrial, google, scholar, cas, cells, central, differentiation, mitochondria, aging, signaling, epigenetic, function, dna, fate, biol, protein, regulation, methylation, role, mitophagy, levels, ros, histone, stress, mtdna, expression, autophagy, pathway, control, human, senescence, wang, fission, cellular, metabolic, metabolism, sirt, drp, pluripotency, potential, regulates, mol, dynamics, hematopoietic, chen, nat,

Topics {✒️}

antioxidant n-acetyl-l-cysteine tgf-β-induced epithelial-mesenchymal transition pten-pi3k/akt/mtor pathway wnt/β-catenin signaling pathway cell-permeable dimethyl α-kg oxygen-glucose deprivation/reperfusion insult α-kg/succinic acid ratio wild-type p53-induced phosphatase mitogen-activated protein kinase fatty acid β-oxidation wnt/β-catenin pathway acetyl-coa-mediated histone acetylation α-kg/succinate ratio induced glucose-derived acetyl-coa mitogen-activated protein kinases van der bliek inhibiting ros–p38-mapk signaling stem cell-based therapy single-cell rna sequencing dna‒protein assemblies consisting parkin/pink1-mediated mitophagy pathway poly adp-ribose polymerases tempo-conjugated gold nanoparticles p38-mapk signaling pathway clinical-grade stem cells bnip3l/nix-mediated mitophagy tubular-epithelial cos7 cells p38-mapk pathway activated cyclic adp-ribose synthases α-kg fine-tunes intracellular α-ketoglutarate maintains mitochondrial metabolic fluctuation-induced α-kg alpha-ketoglutarate alpha-ketoglutarate α-kg mitophagy-driven mitochondrial rejuvenation age-related thymic involution α-ketoglutarate-dependent dioxygenases writing-original draft preparation sirt1-deleted hematopoietic stem oxidative stress-induced responses ucb-mscs undergo senescence α-kg impedes differentiation ros/p38-mapk pathway ros/p38 mapk pathway ameliorating age-related osteoporosis pml–ppar-δ pathway retromer-dependent wnt signaling neural stem/progenitors cells bnip3l-dependent mitophagy accounts dynamin-related protein drp1

Questions {❓}

Chen JH, Hales CN, Ozanne SE (2007) DNA damage, cellular senescence and organismal ageing: causal or correlative?
Harman D (1972) The biologic clock: the mitochondria?
Schröter F, Adjaye J (2014) The proteasome complex and the maintenance of pluripotency: sustain the fate by mopping up?
Van der Wijst MG, Rots MG (2015) Mitochondrial epigenetics: an overlooked layer of regulation?

Schema {🗺️}

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      headline:Emerging roles of mitochondrial functions and epigenetic changes in the modulation of stem cell fate
      description:Mitochondria serve as essential organelles that play a key role in regulating stem cell fate. Mitochondrial dysfunction and stem cell exhaustion are two of the nine distinct hallmarks of aging. Emerging research suggests that epigenetic modification of mitochondria-encoded genes and the regulation of epigenetics by mitochondrial metabolites have an impact on stem cell aging or differentiation. Here, we review how key mitochondrial metabolites and behaviors regulate stem cell fate through an epigenetic approach. Gaining insight into how mitochondria regulate stem cell fate will help us manufacture and preserve clinical-grade stem cells under strict quality control standards, contributing to the development of aging-associated organ dysfunction and disease.
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