We are analyzing https://link.springer.com/article/10.1007/s00018-023-04745-4.

Title:
Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB | Cellular and Molecular Life Sciences
Description:
Monocyte-derived macrophages contribute to pathogenesis in inflammatory diseases and their effector functions greatly depend on the prevailing extracellular milieu. Whereas M-CSF primes macrophages for acquisition of an anti-inflammatory profile, GM-CSF drives the generation of T cell-stimulatory and pro-inflammatory macrophages. Liver X Receptors (LXRα and LXRβ) are nuclear receptors that control cholesterol metabolism and regulate differentiation of tissue-resident macrophages. Macrophages from rheumatoid arthritis and other inflammatory pathologies exhibit an enriched LXR pathway, and recent reports have shown that LXR activation raises pro-inflammatory effects and impairs the acquisition of the anti-Inflammatory profile of M-CSF-dependent monocyte-derived macrophages (M-MØ). We now report that LXR inhibition prompts the acquisition of an anti-inflammatory gene and functional profile of macrophages generated within a pathological environment (synovial fluid from Rheumatoid Arthritis patients) as well as during the GM-CSF-dependent differentiation of human monocyte-derived macrophages (GM-MØ). Mechanistically, inhibition of LXR results in macrophages with higher expression of the v-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog B (MAFB) transcription factor, which governs the macrophage anti-inflammatory profile, as well as over-expression of MAFB-regulated genes. Indeed, gene silencing experiments on human macrophages evidenced that MAFB is required for the LXR inhibitor to enhance the anti-inflammatory nature of human macrophages. As a whole, our results demonstrate that LXR inhibition prompts the acquisition of an anti-inflammatory transcriptional and functional profile of human macrophages in a MAFB-dependent manner, and propose the use of LXR antagonists as potential therapeutic alternatives in macrophage re-programming strategies during inflammatory responses.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

macrophages, lxr, pubmed, article, google, scholar, cas, macrophage, expression, genes, fig, mafb, inhibition, gene, human, gmmø, antiinflammatory, gskgmmø, proinflammatory, inflammatory, profile, central, arthritis, synovial, rheumatoid, gsk, gskrasfmø, differentiation, cell, monocytes, activation, immunol, liver, monocytederived, gmcsf, levels, gse, enrichment, supplementary, rasfmø, acquisition, mmø, generated, factor, independent, analysis, polarization, shown, results, protein,

Topics {✒️}

gm-csf-dependent monocyte-derived gm-mø m-csf-dependent monocyte-derived macrophages granulocyte-macrophage colony-stimulating factor albeit gw/gsk-gm-mø exhibited monocyte-derived pro-inflammatory gm-mø ox-ldl-dependent trained immunity macrophage-deficient op/op mouse gw/gsk-gm-mø produced significantly quantitative real-time rt-pcr macrophage-csf-dependent macrophage responses generate gm-csf-polarized macrophages pid2019-104284rb-i00/aei/https gsk-gm-mø greatly coincided murine collagen-induced arthritis uk/arrayexpress/experiments/e-mtab-8322/ gm-mø-specific gene sets gm-mø-specific genes egln3 pro-inflammatory tlr4 signaling maría teresa schiaffino pro-inflammatory gm-mø transcriptomes gm-csf-driven monocyte article download pdf gsk-gm-mø gene profile monocyte-derived m-mø [48] human monocyte-derived macrophages transcription factor c-maf colony-stimulating factor 1 post-hoc tukey test real-time quantitative pcr broad-spectrum therapeutic suppression anti-inflammatory gene set pro-inflammatory gene set gm-csf-dependent macrophages srebp-dependent gene sets m-csf-polarized macrophages macrophage anti-inflammatory polarization gm-csf-dependent differentiation m-csf-induced macrophages gsk-gm-mø exhibited r-package deseq2 algorithms characterizes tissue-resident macrophages m-csf primes macrophages rheumatoid arthritis synovial fluid promote macrophage pro-inflammatory anti-inflammatory m-mø anti-inflammatory m-mø [23 anti-inflammatory macrophage markers fast gapped-read alignment pro-inflammatory m-mø gm-csf primes macrophages

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB
         description:Monocyte-derived macrophages contribute to pathogenesis in inflammatory diseases and their effector functions greatly depend on the prevailing extracellular milieu. Whereas M-CSF primes macrophages for acquisition of an anti-inflammatory profile, GM-CSF drives the generation of T cell-stimulatory and pro-inflammatory macrophages. Liver X Receptors (LXRα and LXRβ) are nuclear receptors that control cholesterol metabolism and regulate differentiation of tissue-resident macrophages. Macrophages from rheumatoid arthritis and other inflammatory pathologies exhibit an enriched LXR pathway, and recent reports have shown that LXR activation raises pro-inflammatory effects and impairs the acquisition of the anti-Inflammatory profile of M-CSF-dependent monocyte-derived macrophages (M-MØ). We now report that LXR inhibition prompts the acquisition of an anti-inflammatory gene and functional profile of macrophages generated within a pathological environment (synovial fluid from Rheumatoid Arthritis patients) as well as during the GM-CSF-dependent differentiation of human monocyte-derived macrophages (GM-MØ). Mechanistically, inhibition of LXR results in macrophages with higher expression of the v-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog B (MAFB) transcription factor, which governs the macrophage anti-inflammatory profile, as well as over-expression of MAFB-regulated genes. Indeed, gene silencing experiments on human macrophages evidenced that MAFB is required for the LXR inhibitor to enhance the anti-inflammatory nature of human macrophages. As a whole, our results demonstrate that LXR inhibition prompts the acquisition of an anti-inflammatory transcriptional and functional profile of human macrophages in a MAFB-dependent manner, and propose the use of LXR antagonists as potential therapeutic alternatives in macrophage re-programming strategies during inflammatory responses.
         datePublished:2023-03-17T00:00:00Z
         dateModified:2023-03-17T00:00:00Z
         pageStart:1
         pageEnd:13
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s00018-023-04745-4
         keywords:
            Inflammation
            Innate immunity
            Macrophage Polarization
            Transcriptional profile
            Cell Biology
            Biomedicine
            general
            Life Sciences
            Biochemistry
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-023-04745-4/MediaObjects/18_2023_4745_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-023-04745-4/MediaObjects/18_2023_4745_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-023-04745-4/MediaObjects/18_2023_4745_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-023-04745-4/MediaObjects/18_2023_4745_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-023-04745-4/MediaObjects/18_2023_4745_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-023-04745-4/MediaObjects/18_2023_4745_Fig6_HTML.png
         isPartOf:
            name:Cellular and Molecular Life Sciences
            issn:
               1420-9071
               1420-682X
            volumeNumber:80
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer International Publishing
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Arturo González de la Aleja
               affiliation:
                     name:CSIC
                     address:
                        name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Cristina Herrero
               affiliation:
                     name:CSIC
                     address:
                        name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mónica Torres-Torresano
               affiliation:
                     name:Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón
                     address:
                        name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:María Teresa Schiaffino
               affiliation:
                     name:Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón
                     address:
                        name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alejandro del Castillo
               affiliation:
                     name:CSIC
                     address:
                        name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bárbara Alonso
               affiliation:
                     name:CSIC
                     address:
                        name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Miguel A. Vega
               affiliation:
                     name:CSIC
                     address:
                        name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Amaya Puig-Kröger
               affiliation:
                     name:Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón
                     address:
                        name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Antonio Castrillo
               affiliation:
                     name:Universidad de Las Palmas de Gran Canaria
                     address:
                        name:Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Grupo de Investigación Medio Ambiente y Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain
                        type:PostalAddress
                     type:Organization
                     name:Centro Mixto Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC-UAM)
                     address:
                        name:Instituto Investigaciones Biomédicas “Alberto Sols” (IIBM), Centro Mixto Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ángel L. Corbí
               url:http://orcid.org/0000-0003-1980-5733
               affiliation:
                     name:CSIC
                     address:
                        name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB
      description:Monocyte-derived macrophages contribute to pathogenesis in inflammatory diseases and their effector functions greatly depend on the prevailing extracellular milieu. Whereas M-CSF primes macrophages for acquisition of an anti-inflammatory profile, GM-CSF drives the generation of T cell-stimulatory and pro-inflammatory macrophages. Liver X Receptors (LXRα and LXRβ) are nuclear receptors that control cholesterol metabolism and regulate differentiation of tissue-resident macrophages. Macrophages from rheumatoid arthritis and other inflammatory pathologies exhibit an enriched LXR pathway, and recent reports have shown that LXR activation raises pro-inflammatory effects and impairs the acquisition of the anti-Inflammatory profile of M-CSF-dependent monocyte-derived macrophages (M-MØ). We now report that LXR inhibition prompts the acquisition of an anti-inflammatory gene and functional profile of macrophages generated within a pathological environment (synovial fluid from Rheumatoid Arthritis patients) as well as during the GM-CSF-dependent differentiation of human monocyte-derived macrophages (GM-MØ). Mechanistically, inhibition of LXR results in macrophages with higher expression of the v-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog B (MAFB) transcription factor, which governs the macrophage anti-inflammatory profile, as well as over-expression of MAFB-regulated genes. Indeed, gene silencing experiments on human macrophages evidenced that MAFB is required for the LXR inhibitor to enhance the anti-inflammatory nature of human macrophages. As a whole, our results demonstrate that LXR inhibition prompts the acquisition of an anti-inflammatory transcriptional and functional profile of human macrophages in a MAFB-dependent manner, and propose the use of LXR antagonists as potential therapeutic alternatives in macrophage re-programming strategies during inflammatory responses.
      datePublished:2023-03-17T00:00:00Z
      dateModified:2023-03-17T00:00:00Z
      pageStart:1
      pageEnd:13
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s00018-023-04745-4
      keywords:
         Inflammation
         Innate immunity
         Macrophage Polarization
         Transcriptional profile
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-023-04745-4/MediaObjects/18_2023_4745_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-023-04745-4/MediaObjects/18_2023_4745_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-023-04745-4/MediaObjects/18_2023_4745_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-023-04745-4/MediaObjects/18_2023_4745_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-023-04745-4/MediaObjects/18_2023_4745_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-023-04745-4/MediaObjects/18_2023_4745_Fig6_HTML.png
      isPartOf:
         name:Cellular and Molecular Life Sciences
         issn:
            1420-9071
            1420-682X
         volumeNumber:80
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Arturo González de la Aleja
            affiliation:
                  name:CSIC
                  address:
                     name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Cristina Herrero
            affiliation:
                  name:CSIC
                  address:
                     name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mónica Torres-Torresano
            affiliation:
                  name:Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón
                  address:
                     name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:María Teresa Schiaffino
            affiliation:
                  name:Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón
                  address:
                     name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alejandro del Castillo
            affiliation:
                  name:CSIC
                  address:
                     name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bárbara Alonso
            affiliation:
                  name:CSIC
                  address:
                     name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Miguel A. Vega
            affiliation:
                  name:CSIC
                  address:
                     name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Amaya Puig-Kröger
            affiliation:
                  name:Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón
                  address:
                     name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Antonio Castrillo
            affiliation:
                  name:Universidad de Las Palmas de Gran Canaria
                  address:
                     name:Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Grupo de Investigación Medio Ambiente y Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain
                     type:PostalAddress
                  type:Organization
                  name:Centro Mixto Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC-UAM)
                  address:
                     name:Instituto Investigaciones Biomédicas “Alberto Sols” (IIBM), Centro Mixto Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ángel L. Corbí
            url:http://orcid.org/0000-0003-1980-5733
            affiliation:
                  name:CSIC
                  address:
                     name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Cellular and Molecular Life Sciences
      issn:
         1420-9071
         1420-682X
      volumeNumber:80
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:CSIC
      address:
         name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
         type:PostalAddress
      name:CSIC
      address:
         name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
         type:PostalAddress
      name:Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón
      address:
         name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
         type:PostalAddress
      name:Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón
      address:
         name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
         type:PostalAddress
      name:CSIC
      address:
         name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
         type:PostalAddress
      name:CSIC
      address:
         name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
         type:PostalAddress
      name:CSIC
      address:
         name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
         type:PostalAddress
      name:Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón
      address:
         name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
         type:PostalAddress
      name:Universidad de Las Palmas de Gran Canaria
      address:
         name:Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Grupo de Investigación Medio Ambiente y Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain
         type:PostalAddress
      name:Centro Mixto Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC-UAM)
      address:
         name:Instituto Investigaciones Biomédicas “Alberto Sols” (IIBM), Centro Mixto Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain
         type:PostalAddress
      name:CSIC
      address:
         name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Arturo González de la Aleja
      affiliation:
            name:CSIC
            address:
               name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Cristina Herrero
      affiliation:
            name:CSIC
            address:
               name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Mónica Torres-Torresano
      affiliation:
            name:Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón
            address:
               name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
               type:PostalAddress
            type:Organization
      name:María Teresa Schiaffino
      affiliation:
            name:Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón
            address:
               name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Alejandro del Castillo
      affiliation:
            name:CSIC
            address:
               name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Bárbara Alonso
      affiliation:
            name:CSIC
            address:
               name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Miguel A. Vega
      affiliation:
            name:CSIC
            address:
               name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Amaya Puig-Kröger
      affiliation:
            name:Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón
            address:
               name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Antonio Castrillo
      affiliation:
            name:Universidad de Las Palmas de Gran Canaria
            address:
               name:Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Grupo de Investigación Medio Ambiente y Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain
               type:PostalAddress
            type:Organization
            name:Centro Mixto Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC-UAM)
            address:
               name:Instituto Investigaciones Biomédicas “Alberto Sols” (IIBM), Centro Mixto Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Ángel L. Corbí
      url:http://orcid.org/0000-0003-1980-5733
      affiliation:
            name:CSIC
            address:
               name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
      name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
      name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
      name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
      name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
      name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
      name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
      name:Unidad de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
      name:Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Grupo de Investigación Medio Ambiente y Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain
      name:Instituto Investigaciones Biomédicas “Alberto Sols” (IIBM), Centro Mixto Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain
      name:Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain

External Links {🔗}(380)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.53s.

LINK . SPRINGER . COM {}